Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer응급실 스트레스 상태의 급성기에 대응하기 위해 항혈소판제 티클로피딘의 용도 변경: 코로나바이러스 감염 및 암 퇴치를 위한 기회Article Published on 2022-07-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, [키워드] Achille agent antiplatelet Antiplatelet agent approach approved drugs attribute Cancer Cancer cells Cell Coronavirus infections Coronavirus-2 COVID-19 demonstrated Endoplasmic reticulum endoplasmic reticulum (ER) ER membranes ER stress exacerbating Fighting heel homeostasis life cycle Metastasis Modification modulation opportunity P2Y12 P2Y12 inhibitors pathological conditions Perturbation phase promote receptor representing repurposing responsible SARS Coronavirus SARS-CoV-2 sigma sigma 1 receptor (S1R) terminal UPR the disease therapeutic intervention Therapies ticlopidine ticlopidine. Tumor tumor growth unfolded protein response UPR viral glycoprotein viral glycoproteins viral infection viral infections viral life cycle [DOI] 10.3390/molecules27144327 PMC 바로가기 [Article Type] Article
Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residentsResearch article Published on 2021-08-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, 치료제, [키워드] acute COVID-19 acute respiratory syndrome ALF Ambulatory treatment Anti-infective Anti-inflammatory Anticoagulant Antiplatelet agent Antithrombotic Antiviral benefit Care clinical suspicion coronavirus Corticosteroid Corticosteroids COVID-19 Cytokine storm death deaths doctor early treatment elderly Elderly patient endothelial injury helping high-risk patient highest hospital Hospitalization Hydroxychloroquine Hypothesis illness Immunity implication In-hospital Infection initial initiated kidney LTF Lungs morbidity and mortality Mortality natural immunity nine nursing home outbreak outcome Patient patients Population positive post infection Prevent Probability provide pulmonary failure receive reduce reduced reduction in mortality regimen Repurposed drug risk robust SARS-CoV-2 SARS-COV-2 infection sequenced severity sick significantly Spread statistically significant Symptom the disease the patient therapeutic option therapy thrombosis Transmission treat Treatment viral replication with COVID-19 worsening [DOI] 10.1016/j.mehy.2021.110622 [Article Type] Research article
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)Review Published on 2020-12-302023-07-13 Journal: Rev Cardiovasc Med [Category] SARS, [키워드] Ambulatory treatment Anti-infective Anti-inflammatory Anticoagulant Antiplatelet agent Antiviral Corticosteroid COVID-19 Hospitalization Mortality SARS-CoV-2 sequenced multidrug therapy. [DOI] 10.31083/j.rcm.2020.04.264 PMC 바로가기 [Article Type] Review