A Comparative Study of Antiretroviral (Lopinavir/Ritonavir) and Remdesivir Used in the Pandemic in Iraq on the Clinical Outcome in Patients with SARS-CoV-2Original Article Published on 2023-06-302024-09-05 Journal: Archives of Razi Institute [Category] update2024, [키워드] antiretroviral drugs coronavirus COVID-19 Lopinavir-ritonavir Remdesivir SARS-CoV-2 [DOI] 10.22092/ARI.2022.360354.2574 PMC 바로가기 [Article Type] Original Article
Resource and infrastructure challenges on the RESIST-2 Trial: an implementation study of drug resistance genotype-based algorithmic ART switches in HIV-2-infected adults in Senegal저항 2 시험의 자원 및 인프라 과제 : 세네갈의 HIV-2에 감염된 성인의 약물 저항성 유전자형 기반 알고리즘 아트 스위치의 구현 연구Clinical Trial Published on 2021-12-182022-09-01 Journal: Trials [Category] SARS, 임상, 진단, [키워드] AIDS Algorithm antiretroviral drugs Antiretroviral therapy ART Blood can be used conducted Controlled trial counseling COVID-19 COVID-19 pandemic defined demonstrated dolutegravir drug resistance drug resistance testing enrolled Evidence evidence of Follow-up funding genotypes genotypic help HIV treatment HIV-2 implementation Implementation study inhibitor lack mutations National no evidence of nucleoside outcome participant Participants Patient per-protocol point-of-care prevented problem problems protease Protease inhibitor receiving regimen Result reverse transcriptase RLS Seattle single-arm trial suppressed switching transcriptase Treatment Trial Trial registration Viral Viral load Viral suppression VL testing was performed were assessed [DOI] 10.1186/s13063-021-05902-5 PMC 바로가기 [Article Type] Clinical Trial
Clinical outcomes of COVID-19 amongst HIV patients: a systematic literature reviewHIV 환자 중 COVID-19의 임상 결과: 체계적인 문헌 검토Covid-19 Published on 2021-05-172022-09-11 Journal: Epidemiology and Health [Category] 치료제, [키워드] Acquired immunodeficiency syndrome age antiretroviral drug antiretroviral drugs carried caused city clinical clinical impact Clinical outcome clinical outcomes Cochrane Library Coinfection Comorbidities comparable coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 infection database Dyspnoea Fever General population global pandemic highlight HIV HIV patient HIV patients Human immunodeficiency virus hypertension immunodeficiency virus infections item literature review males median age medical system meta-analyses Mild mild to moderate mild to moderate symptoms moderate morbidity and mortality MOST obesity Older age outcome Patient patients pressure prevalent PRISMA receiving reported Reporting review SARS-CoV-2 Still Symptoms systematic reviews the median virus Wuhan Wuhan, China [DOI] 10.4178/epih.e2021036 PMC 바로가기 [Article Type] Covid-19
The Efficacy of Computerized Cognitive Behavioral Therapy for Depressive and Anxiety Symptoms in Patients With COVID-19: Randomized Controlled TrialCOVID-19 환자의 우울 및 불안 증상에 대한 컴퓨터화된 인지 행동 치료의 효능: 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-142022-08-13 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] AIS antidepressants antiretroviral drug antiretroviral drugs Anxiety anxiety symptom assessment assessments Athens Insomnia Scale behavioral therapy carried CBT cCBT cCBT + TAU cCBT + TAU group cCBT intervention cCBT program Chinese clinical Clinical treatment cognitive behavioral therapy Computerized CBT computerized cognitive behavioral therapy Controlled COVID-19 COVID-19 pandemic Depression depressive drug Drug-to-drug interaction drug-to-drug interactions Effect effective Effectiveness Efficacy evaluate face-to-face therapy female FIVE follow-up period HAMA HAMD Hamilton Anxiety Scale Hamilton Depression Rating Scale Insomnia Intervention intervention program measure mental health middle school no significant difference no significant differences nonpharmacological treatment objective Patient patients with COVID-19 postintervention Prevalence Previous studies previous study psychological therapy Randomized Registration registry repeated measure Research Result Safe SAS scale scored Screening SDS secondary outcome measure secondary outcome measures Self-Rating Anxiety Scale Self-Rating Depression Scale shown significantly Symptom symptoms of depression Tau TAU group the patient therapist Treatment treatment as usual treatment method two groups were assessed [DOI] 10.2196/26883 PMC 바로가기 [Article Type] Randomized Controlled Trial
Antiretrovirals for Prophylaxis Against COVID-19: A Comprehensive Literature ReviewCOVID-19 예방을 위한 항레트로바이러스제: 종합 문헌 검토Review Published on 2021-05-012022-09-11 Journal: Journal of clinical pharmacology [Category] SARS, 치료제, [키워드] acute respiratory syndrome Against animal antiretroviral antiretroviral drugs Antiretrovirals article ARV binding affinity clinical evidence cohort study Comorbidity Comprehensive consequence Corona virus Course COVID-19 darunavir database emtricitabine enzyme Evidence expected HIV Human immunodeficiency virus identify immunodeficiency virus in vitro Infection inhibitor literature Lopinavir molecular molecular docking studies nelfinavir nucleoside nucleotide ongoing trial ongoing trials patients Postexposure Prophylaxis Prophylactic Prophylaxis Protease inhibitor protease inhibitors review Ritonavir SARS-CoV-2 SARS-COV-2 infection searched Severe acute respiratory syndrome shown subgroup Support tenofovir the disease virus Virus Disease [DOI] 10.1002/jcph.1788 PMC 바로가기 [Article Type] Review
What we have to know about corticosteroids use during Sars-Cov-2 infectionSars-Cov-2 감염 중 코르티코스테로이드 사용에 대해 알아야 할 사항Review Published on 2021-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] SARS, 치료제, [키워드] acute respiratory syndrome addition Adrenal Adrenal insufficiency affected antiretroviral drug antiretroviral drugs antiviral therapy available data caused co-morbidities concomitant treatments consequence Corticosteroid Corticosteroids cortisol COVID-19 COVID-19 outbreak Critical Critical illness dose drug drug interaction Drug interference drug withdrawal drug-drug interaction drugs ENhance exposure to gcs Glucocorticoid treatment Glucocorticoids HPA hypercortisolism hypoadrenalism impairment Infection Interaction involved literature management morbidities morbidity and mortality mortality risk pathway Patient physician risk SARS-CoV SARS-CoV 2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients secretion Severe acute respiratory syndrome Steroids Symptom therapy treat Treatment Withdrawal [DOI] 10.1007/s40618-020-01384-5 PMC 바로가기 [Article Type] Review
COVID-19 in people living with HIV: Clinical implications of dynamics of the immune response to SARS-CoV-2HIV 감염자의 COVID-19: SARS-CoV-2에 대한 면역 반응 역학의 임상적 의미Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission antiretroviral drugs Antiretroviral therapy CD4+ Cellular immune response clinical clinical picture coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines disease severity dysregulation elicited Evidence evidence of FIVE greater highest HIV HIV infection HIV patients immune activation immune response Immunoglobulin Immunoglobulin G immunological Immunosuppression implication increased risk Inflammatory maximum Mild Nasopharyngeal swab nasopharyngeal swabs Neutralizing antibodies neutralizing antibody occurred on admission Patient patients PLWH Pneumonia Proinflammatory cytokine proinflammatory cytokines protective role reported respiratory Respiratory failure RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of COVID-19 T-cell activation two patients Viral viral clearance with COVID-19 with HIV [DOI] 10.1002/jmv.26556 PMC 바로가기 [Article Type] Article
Virtual screening of phytochemical compounds as potential inhibitors against SARS-CoV-2 infectionResearch Published on 2021-01-282022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] acute respiratory illness ADME Analysis antiretroviral drugs binding Cell Compound coronavirus Coronavirus infection death diagnosed diagnostic docking drug drugs effective inhibitor Efficacy GRP78 H-bond highest Host hydrophilicity hydrophobic identify in silico drug design In silico method India Infection inhibit inhibitor Interaction Molecular docking study pandemic performed permeation Physicochemical properties receptor Repurposed drug residue Result Retroviral infection reveal S-protein Safe SARS-COV-2 infection screened Side-effect supplementary material surface receptor Toxicity treated Treatment Virtual screening virus Western Ghats [DOI] 10.1186/s43088-021-00095-x PMC 바로가기 [Article Type] Research
Efficacy and safety of nitazoxanide plus atazanavir/ritonavir for the treatment of moderate to severe COVID-19 (NACOVID): A structured summary of a study protocol for a randomised controlled trial중등도에서 중증의 COVID-19(NACOVID) 치료를 위한 nitazoxanide + atazanavir/ritonavir의 효능 및 안전성: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Comparative Study Published on 2021-01-042022-09-10 Journal: Trials [Category] 신약개발, 임상, 치료제, [키워드] 1:1 24 hour 24 hours achievement addition Administered African age allocation anticipated antiretroviral drugs antiviral activity approval Atazanavir atazanavir/ritonavir Blinding Care clinical Clinical improvement Clinical management Comorbidities confirmation Control control group COVID-19 COVID-19 diagnosis COVID-19 infection criteria defined determined by diagnosed Diagnosis discharge dissemination drug Drug administration drugs Efficacy and safety element eliminated enrolment exclusion criteria food Food and Drug Administration Gender group hospital hypersensitivity include inclusion criteria Infectious diseases information initiation of treatment Interaction intervention group Isolation lactating mechanical ventilation medication moderate moderate to severe multicentre Nasopharyngeal swab negativity Nigeria nitazoxanide number objective Ogun once daily Open-label open-label trial Ordinal Scale outcome measure Pan Pan African Clinical Trials Registry participant Patient PCR PCR test Phase 2 physician polymerase chain polymerase chain reaction positive pregnant Proportion of participant protocol quantified randomisation randomised randomised controlled trial receive receiving recruited REDCap Registered registry reported Ritonavir RT-PCR Saliva Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 polymerase chain reaction SARS-CoV-2 viral load secondary care sequence severe COVID-19 specialist Standard Standard of care state Stratification Study protocol supplementary material symptomatic Teaching Temporal the WHO time Treatment Trial Trial registration university Viral Viral load website working [DOI] 10.1186/s13063-020-04987-8 PMC 바로가기 [Article Type] Comparative Study
Effect of nevirapine, efavirenz and lopinavir/ritonavir on the therapeutic concentration and toxicity of lumefantrine in people living with HIV at Lagos University Teaching Hospital, NigeriaArticle Published on 2020-11-302024-09-09 Journal: J Pharmacol Sci [Category] 말라리아, [키워드] antiretroviral drugs HIV Lumefantrine malaria Therapeutic concentrations. PMC 바로가기