Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 공유 결합제로서의 C형 간염 바이러스 NS3/4A 억제제 및 기타 약물 유사 화합물Article Published on 2022-07-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro active site Antiviral antiviral inhibitor approved binding catalytic cause clinical trials clinically Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics Cys145 derivative derivatives drug drug target Evidence global public health hepatitis C hepatitis C virus higher affinity inhibitor M pro maturation molecular docking studies Molecular docking study pandemic polyproteins protease Protein residue SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 main protease Severe acute respiratory syndrome Spread the SARS-CoV-2 genome Vaccine variants virus [DOI] 10.1038/s41598-022-15930-z PMC 바로가기 [Article Type] Article
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundleSARS-CoV-2 스파이크 후 융합 번들의 변종 간의 구조적 보존Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter antiviral inhibitor antiviral inhibitors assembly change coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cryo-EM cryogenic electron microscopy determine domain eight functional glycoprotein heptad repeat host cell HR1HR2 Interaction local effect membrane fusion Microscopy molecular monoclonal antibody mutant Mutation mutations Nostoc omicron Omicron variant postfusion related viruses reported resulting SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected severe acute respiratory syndrome Coronavirus similar studies similar study spike glycoprotein Structure structures target the SARS-CoV-2 therapy trimeric variant variants of SARS-CoV-2 Viral RNA viral spike wild-type [DOI] 10.1073/pnas.2119467119 PMC 바로가기 [Article Type] Article
Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitorsResearch Article Published on 2021-12-202022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome Analysis antiviral inhibitor antiviral therapeutics biochemical C-terminal complex coronavirus COVID-19 COVID-19, Coronavirus disease 2019 CV, column volume DDEE, residues forming the active site aspartic acid (D) and glutamic acid (E) DMSO, dimethyl sulfoxide DSF, differential scanning fluorimetry ENhance enzyme enzyme kinetics Escherichia coli exonuclease exonucleases Exoribonuclease expression Factor FL, full-length highlight increase in inhibit inhibitor methyltransferase monophosphate MP, monophosphate MTase, methyltransferase N-terminal Ni, nickel nonstructural protein 14 NP-40, Nonidet-P40 nsp10 nsp14 NSP14, nonstructural protein 14 NTA, nitrilotriacetic acid observé producing Protein protein complex protein drug interaction Protein purification protein stability protein–protein interaction Proteins protocol provide purification Remdesivir Replication required RMP, remdesivir monophosphate SAH, S-adenosylhomocysteine SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography small molecule TCEP, Tris(2-carboxyethyl)phosphine the SARS-CoV-2 the SARS-CoV-2 genome Treatment understanding viral proofreading Viral protein [DOI] 10.1016/j.jbc.2021.101518 PMC 바로가기 [Article Type] Research Article
Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission routeSARS-CoV-2 B.1.351 변이체에 의한 야생형 마우스 감염은 가능한 새로운 종간 전파 경로를 나타냅니다Article Published on 2021-12-142022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] accompanied addition angiotensin angiotensin-converting enzyme 2 animal model antiviral inhibitor antiviral inhibitors B.1.351 binding affinity caused Contact COVID-19 COVID-19 pathogenesis Cross-species transmission Cytokines direct contact elevated enzyme Epidemic evaluate expand expressed Genetic modifications host range human population human populations increase indicate Infection Infectious diseases lung Lungs mACE2 mice Modification Mutation pathological change Proinflammatory cytokine proinflammatory cytokines RBD Receptor-binding domain regulated replicated SARS-CoV-2 SARS-CoV-2 B.1.351 variant SARS-CoV-2 variant sera Spike protein strain susceptible the receptor-binding domain the SARS-CoV-2 tracheas Transmission transmission of SARS-CoV-2 Vaccines variant Viral viral infection wild-type zoonotic disease [DOI] 10.1038/s41392-021-00848-1 PMC 바로가기 [Article Type] Article
Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19COVID-19에 대한 항바이러스 억제제 식별을 위한 SARS-CoV-2 Guanine-N7 methyltransferase(nsp14)의 구조 기반 가상 스크리닝 및 분자 역학 시뮬레이션Article Published on 2021-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] adenosine antiviral inhibitor antiviral inhibitors binding binding site C-terminal caused cellular immune responses Chinese Combination Compound Computational approaches conserved coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics database domain drug target ensemble sampling enzyme evade Final genomic genomic RNA guanine Guanosine homology Host identify immune responses inhibiting inhibitor inhibitors Innate immunity interfere International involved main role MD simulations mechanism medical emergency Medicine Methylation methyltransferase molecular molecular dynamics Molecular dynamics simulation N7-MTase natural products nsp14 pandemic PCA performed protein targets provide researcher residue respiratory RNA RNA capping RNAs SARS-CoV SARS-CoV-2 screened Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Specificities TCM the SARS-CoV-2 Traditional Traditional Chinese medicine unique viral genomic RNA Virtual screening [DOI] 10.1080/07391102.2020.1778535 PMC 바로가기 [Article Type] Article
Knowing and combating the enemy: a brief review on SARS-CoV-2 and computational approaches applied to the discovery of drug candidates적을 알고 싸우기: SARS-CoV-2에 대한 간략한 검토 및 약물 후보 발견에 적용된 컴퓨터 접근 방식Review Published on 2021-03-262022-08-31 Journal: Bioscience Reports [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome antiviral inhibitor antiviral inhibitors applied approaches artificial intelligence China combating computational approach Computational approaches computer-aided drug design coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical death drug candidate Drug discovery and design effort Health infections knowledge machine learning mitigate overcome pandemic Research respiratory SARS-CoV-2 therapeutic options Treatment urge urgency virus [DOI] 10.1042/BSR20202616 PMC 바로가기 [Article Type] Review
A Neutralization Assay Based on Pseudo-Typed Lentivirus with SARS CoV-2 Spike Protein in ACE2-Expressing CRFK CellsArticle Published on 2021-02-022022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 293T ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 anti-SARS-CoV-2 anti-spike antibody Antisera antiviral inhibitor applied Cell coated with contribute convalescent coronavirus COVID-19 CrFK CRFK Cell Dilution effective embryonic kidney ENhance evaluate HEK293T highly pathogenic HIV host cell human convalescent sera IC50 IgA IgG IgM Immunoglobulin immunoglobulin A IMPROVE Infection inhibitor inhibitory concentration kidney lentivirus mAbs methodology monoclonal monoclonal antibody Neutralization assay neutralizing monoclonal antibody pseudo-typed lentivirus reagent required researcher SARS CoV-2 SARS-CoV-2 spike Spike protein Spread the SARS-CoV-2 virus Virus neutralization zoonotic [DOI] 10.3390/pathogens10020153 PMC 바로가기 [Article Type] Article
Assessment of proton-coupled conformational dynamics of SARS and MERS coronavirus papain-like proteases: Implication for designing broad-spectrum antiviral inhibitorsARTICLES Published on 2020-09-212022-10-30 Journal: The Journal of Chemical Physics [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiviral drug antiviral inhibitor assessment assist calculated catalytic caused computation conformational coronavirus CoV cysteine cysteine protease drug target Evidence flexible GPU Hypothesis inhibitor lack MERS coronavirus MERS-CoV Middle East modulate molecular Outbreaks pandemic Papain-like protease physiological plasticity PLPro Prevent protonation state residue respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Simulation starting point structure-based design Support supported viral life cycle [DOI] 10.1063/5.0020458 PMC 바로가기 [Article Type] ARTICLES
Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray crystallographyArticle Published on 2020-06-242022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] 3CL antiviral inhibitor catalytic site caused coronavirus COVID-19 disease crystal structures drug target facilitate Health Hydrolases information M pro molecular docking studies non-structural proteins pandemic physiological temperature plasticity polyprotein protease reported SARS-CoV-2 Structure Target validation temperature the SARS-CoV-2 translated unliganded viral replication Viral RNA X-ray X-ray crystallography [DOI] 10.1038/s41467-020-16954-7 PMC 바로가기 [Article Type] Article
Structure of the RNA-dependent RNA polymerase from COVID-19 virusReport Published on 2020-05-152022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] addition Analysis antiviral drug antiviral drugs antiviral inhibitor antiviral therapeutics appear bind caused cofactor complex conserved Coronaviral coronavirus disease COVID-19 COVID-19 virus death determine domain full-length Infection Microscopy N terminus Novel coronavirus Nsp12 nucleotide outbreak pandemic polymerase provide RdRP Remdesivir Replication resulting RNA-dependent RNA polymerase Science Scientific community Structure Transcription viral replication Viral RNA virus [DOI] 10.1126/science.abb7498 PMC 바로가기 [Article Type] Report