antiviral therapeutics – Communicable Diseases Research

Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제,

Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligands

Article

Published on 2022-10-012022-11-15
Journal: Febs Letters [Category] COVID19(2023년), SARS, 치료제,

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

Research article

Published on 2022-08-242022-10-05
Journal: Molecular Therapy. Nucleic Acids [Category] 치료제,

[키워드] acute respiratory syndrome antiviral activity antiviral response antiviral therapeutic antiviral therapeutics base base pairs blunt cell lines Characteristics coronavirus coronavirus disease COVID-19 described DNA double-stranded RNA dsRNAs groups highlight Hoogsteen G-G base pairing human lung IFN IFN-I IFN-III immunostimulant immunostimulatory immunostimulatory RNA independent induce Infection Influenza influenza A virus interferon lack lung MERS-CoV Middle East monophosphate motif MT: Oligonucleotides not affect organ on a chip pandemic pathophysiology pathway proinflammatory receptor respiratory syndrome coronavirus respiratory virus RIG-I RNA RNAs SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence siRNAs terminal hydroxyl Therapies and Applications TLR type I type III interferon unique
[DOI] 10.1016/j.omtn.2022.08.031 [Article Type] Research article

Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (M pro)

SARS-CoV-2 주요 프로테아제(M pro)의 유망한 억제제로서 해양 다환식 batzelladine 알칼로이드의 구조-활성 관계 조사

Article

Published on 2022-08-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료제,

Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2

고전적 지문과 비교하여 양자에서 영감을 받은 방법을 기반으로 한 약물 용도 변경은 SARS-CoV-2에 대한 잠재적인 항바이러스제를 밝혀냅니다.

Article

Published on 2022-07-182022-09-11
Journal: PLoS Computational Biology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] accelerated Algorithm Alpha Antiviral antiviral therapeutics approach approved B.1.1.7 B.1.351 B.1.617.2 Beta binary BMS-986094 Cell culture classical cobalamin Combination comparison Comparisons complex complexity Compound compounds computational resource computational resources COVID-19 pandemic cytotoxicity Delta demonstrated Drug repurposing DrugBank database Efficacy England evaluate form GS-6620 IC50 identify in vitro inhibit inhibited inhibitors inhibitory concentration limit maximum optimization overlap pace parameter predicted problem RdRP Remdesivir replication of SARS-CoV-2 resolved RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection screening method several variant several variants strain these compound these compounds vitamin B12 while
[DOI] 10.1371/journal.pcbi.1010330 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling

항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별

Article

Published on 2022-07-012022-09-11
Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제,

[키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used
[DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article

Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2

SARS-CoV-2의 복제 주기에 대한 식물 유래 소분자 억제제의 다면적 역할

Review

Published on 2022-07-012022-09-11
Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Anti-inflammatory anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Anti-viral antioxidant antiviral therapeutics approved assembly caused clinical trial compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug candidate Economy Factor Google Scholar help highlight Host inhibiting knowledge mechanism New coronavirus plant plants platform polyprotein public health registry Replication SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules therapeutic approaches therapy Vaccine viral entry Viral replication cycle.
[DOI] 10.1016/j.micpath.2022.105512 PMC 바로가기 [Article Type] Review

Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro

다양한 PET병 일본 녹차 및 차 화합물의 시험관 내 항 SARS-CoV-2 활성

Article

Published on 2022-07-012022-09-11
Journal: Archives of Virology [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral therapeutics caused Compound compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment demonstrated Dilution dose-dependent manner Effectiveness EGCG Epicatechin epigallocatechin epigallocatechin gallate examined gallate global public health green green tea half-maximal inhibitory concentration half-maximal inhibitory concentrations in vitro inactivated Infection infectious titers inhibit SARS-CoV-2 inhibited investigated Japanese life cycle other compound other compounds outbreak polyethylene terephthalate Prophylaxis protease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus shown Stage the SARS-CoV-2 treat Treatment Vaccine variety viral life cycle Viral RNA virucidal
[DOI] 10.1007/s00705-022-05483-x PMC 바로가기 [Article Type] Article

Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics

COVID-19의 기계론적 모델: 질병 진행, 백신 및 치료제에 대한 통찰력

Review

Published on 2022-07-012022-09-11
Journal: International journal of antimicrobial agents [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제,

Advances in Nanomaterial-Based Platforms to Combat COVID-19: Diagnostics, Preventions, Therapeutics, and Vaccine Developments

COVID-19 퇴치를 위한 나노물질 기반 플랫폼의 발전: 진단, 예방, 치료제 및 백신 개발

Review

Published on 2022-06-202022-09-11
Journal: ACS applied bio materials [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제,