The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection [DOI] 10.15252/emmm.202216643 PMC 바로가기
Comparison and Harmonization of Different Semi-Automated and Automated qRT-PCR Assays in the Assessment of SARS-CoV-2Article Published on 2022-10-122022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis Applying assays assessment automated carried comparability Concentration COVID-19 cycle threshold Cycle threshold value detectable diagnostics FIVE harmonization highlight identify infected individuals Isolation Laboratory lowest mandatory oropharyngeal swab Patient qRT-PCR qRT-PCR assay Qualitative Quantitative quantitative reverse transcriptase-polymerase chain reaction RIDA SARS-CoV-2 SARS-CoV-2 qRT-PCR sensitivity significant difference significantly the median Viral load [DOI] 10.3390/v14102239 PMC 바로가기
A How to Guide: Clinical Population Test Development and Authorization of MALDI-ToF Mass Spectrometry-Based Screening Tests for Viral InfectionsArticle Published on 2022-09-032022-11-15 Journal: Viruses [Category] 치료기술, [키워드] applied Applying Asymptomatic asymptomatic screening authorization Bacteria Bacterial CLIA CLIA-LDT clinical clinical process clinical testing COVID-19 criteria detection development diagnostic fungi Infection Laboratory limits MALDI-TOF MS mass MS test overcome pathogenic Population Population screening Proteins regulatory authority SAR-CoV-2 SARS-CoV-2 Screening Systems biology Test viral infection viral infections Viral protein virus viruses [DOI] 10.3390/v14091958 PMC 바로가기
Increased Online Aggression During COVID-19 Lockdowns: Two-Stage Study of Deep Text Mining and Difference-in-Differences AnalysisArticle Published on 2022-08-092022-11-16 Journal: Journal of Medical Internet Research [Category] 치료기술, [키워드] Affect aggression Analysis applied Applying causal relationship caused computer conducted content analysis COVID-19 COVID-19 pandemic Critical deep demonstrated detect Effects effort emotional emotions Factor Factors fixed greater help Impact increase in Increased independent infodemiology information infoveillance Internet lockdown lockdowns measure media mental health natural language processing neural networks online aggression pandemic positive correlation public health crisis representation Research selected sentiment analysis social media spatiotemporal stability statistically significant subject text The United States transformer Twitter understanding virus [DOI] 10.2196/38776 PMC 바로가기
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV Analysis Antigen antigens applied Applying approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Research Published on 2022-07-282022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] acute infection acute respiratory distress Amino acid Analysis Applying ARDS carbon source CD4+ T cell CD4+ T cells COVID-19 Glycolysis highlight host adaptation immune response Impaired individual induce infected with SARS-CoV-2 infections influence interferon-γ ketogenic metabolism mice Mortality oxidative phosphorylation Patient promote provide Pulmonary infection pulmonary viral reducing severe COVID-19 severe respiratory infections skewed survival syndrome T cell T cell dysfunction T cell response [DOI] 10.1038/s41586-022-05128-8 [Article Type] Research
Applying the RE-AIM framework to evaluate a holistic caregiver-centric hospital-to-home programme: a feasibility study on Carer MattersArticle Published on 2022-07-192022-10-05 Journal: BMC health services research [Category] 임상, [키워드] addressed adopted adoption affecting Applying approach Care Caregiver caregiver burden Caregiver stress Caregiving clinician collected Community condition conducted Course courses disease ecosystem effective emotional enrolled evaluate family feasibility Feasibility study highlight hospital implementation Implementation science initial involved Isolation knowledge maintenance majority matter Nurses Older pandemic Person Person-centered care. Perspective Prolonged provided qualitative data Quantitative data recipients recruitment reduced reported resource resources screened Singapore Stress Support was collected were given [DOI] 10.1186/s12913-022-08317-3 PMC 바로가기 [Article Type] Article
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps Research Published on 2022-07-152022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] alteration Applying assays AST caused Cell cells change Concentration controls deleted deleterious mutation Deletion deletion mutants deletions E. coli E. coli cell Escherichia coli examination fluorescent greater identify isolate K-12 membrane integrity Microscopy over-expressed overexpression phenotype resistance gene resistance mechanisms Result SEM shown susceptibility tested transformant Transport [DOI] 10.1038/s41598-022-15775-6 [Article Type] Research
Enhancing untargeted metabolomics using metadata-based source annotation Research Published on 2022-07-072022-10-05 Journal: Nature biotechnology [Category] 진단, [키워드] Analysis Applying approach Enhancing Human increase metabolomics molecular features Tandem mass spectrometry [DOI] 10.1038/s41587-022-01368-1 [Article Type] Research