Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UKArticle Published on 2022-10-012022-11-16 Journal: Pharmaceutical medicine [Category] 신약개발, [키워드] activities adaptive approval arise contribute country COVID-19 COVID-19 pandemic current develop Dexamethasone ENhance flexible Health involved lesson Medicines multi-arm novel Pandemics question rare diseases RECOVERY trial reduce Regulation Regulatory regulatory pathways shown Stress therapy Trial trials UK Medicine United Kingdom urgency [DOI] 10.1007/s40290-022-00439-7 PMC 바로가기
Decreased Efficiency of Neutralizing Antibodies from Previously Infected or Vaccinated Individuals against the B.1.617.2 (Delta) SARS-CoV-2 VariantArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome adaptive analyzed antibody antibody concentration arise B cell B.1.617.2 binding binding antibodies binding antibody binding antibody unit blood sample collected Concentration coronavirus correlated Decreased Delta delta variant greater HCW HCWs Health care worker immune responses Immunity immunoassay individual Infection injection interquartile range IQR less maintain median neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response Neutralizing antibody titer neutralizing capacity Postinfection protection Protective question recent reduction in Registered required responses SARS-CoV-2 severe disease T cell the SARS-CoV-2 Transmissibility two virus strains vaccination Vaccine variants were measured [DOI] 10.1128/spectrum.02706-21 PMC 바로가기
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease Research Published on 2022-08-162022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] accompanied alteration arise Cell cellular ciliary detect dysfunction environmental factors Gene Expression Genetic hedgehog impairment inhibition mitochondrial dysfunction morphology mouse model neurodegenerative disorder neurons observé overactive Parkinson’s disease pathological mechanism pathway patients phenotype precursor required SHH Signal transduction Signaling single-cell therapy transcriptomics [DOI] 10.1038/s41467-022-32229-9 [Article Type] Research
Network methods and design of randomized trials: Application to investigation of COVID-19 vaccination boosters네트워크 방법 및 무작위 시험 설계: 코로나19 백신 부스터 조사에 적용Article Published on 2022-08-012022-09-11 Journal: Clinical Trials (London, England) [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, 치료제, [키워드] Analysis antibody tests application approach approval arise booster Booster vaccine booster vaccines can be used Characteristics Clinical efficacy Cluster Combination consequence Contact COVID-19 COVID-19 vaccination detectability disease Effect Efficacy enrolled error evaluate the effect Evidence evidence of feasible flexible framework Guidance HIV HIV prevention incidence Infection infections infectiousness information intervention effect Intervention effects magnitude Molecular epidemiology motivation network network science neutralizing antibody novel populations Pragmatic provide random Randomized randomized trial randomized trials reduce cost Sample size SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants Spread Standard of care statistical Study design susceptibility Transmission Trial United Kingdom Vaccine vaccine efficacy variant [DOI] 10.1177/17407745221111818 PMC 바로가기 [Article Type] Article
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination예방 접종 없이 SARS-CoV-2 Omicron에 대한 제한된 교차 변이 면역Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Activation arise Brain brains Breakthrough infection cause Cytokines Delta disease elicited ENhance expression human ACE2 receptor humans humoral immune response Immunity individual individuals induce Infection infections lead Limited lung Lung disease Lungs mice Mild Mild disease neutralization neutralize omicron other variant overexpressing pandemic pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines question reduced replicate risk SARS-CoV-2 SARS-CoV-2 delta sera Symptoms T cells titre vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern WA1 widespread [DOI] 10.1038/s41586-022-04865-0 PMC 바로가기 [Article Type] Article
Pulmonary and Systemic Pathology in COVID-19Article Published on 2022-06-242022-11-15 Journal: Deutsches Ärzteblatt international [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory distress affected Alter Analysis Angiogenesis ARDS arise Autopsy Brain cardiovascular system Central nervous system change clinical picture concerning contribute COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Endothelium Evidence gastrointestinal tract interstitial invagination Ischemia kidneys liver Lungs mechanisms molecular organ organ damage outbreak pandemic pathophysiology Placenta pulmonary Regulatory retrieved risk factor selective severe cases syndrome systemic thrombosis tissue various tissue vessel [DOI] 10.3238/arztebl.m2022.0231 PMC 바로가기
SARS-CoV-2 Whole-Genome Sequencing by Ion S5 Technology-Challenges, Protocol Optimization and Success Rates for Different StrainsIon S5 기술에 의한 SARS-CoV-2 전체 게놈 시퀀싱 - 다양한 균주에 대한 과제, 프로토콜 최적화 및 성공률Article Published on 2022-06-062022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amplicon arise assigned cDNA Concentration construction COVID-19 COVID-19 pandemic demonstrated diagnostics Effectiveness Emergency genomic data idea immunization Ion less library library preparation lineages Modification molecular Molecular epidemiology mRNA mRNA or viral vector vaccines Mutation Next-generation sequencing NGS optimization Panel Patient Poland produced protocol Public public health emergency Rate Real-time PCR required RT-PCR SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage SARS-CoV-2 sequencing Scientific community Sequencing strain Support Surveillance Thermo Fisher Scientific variant variants variants of concern Viral Viral load Viral RNA Viral vector vaccines whole-genome whole-genome sequencing [DOI] 10.3390/v14061230 PMC 바로가기 [Article Type] Article
Dual-site ligation-assisted loop-mediated isothermal amplification (dLig-LAMP) for colorimetric and point-of-care determination of real SARS-CoV-2실제 SARS-CoV-2의 비색 및 현장 진단을 위한 이중 사이트 결찰 보조 루프 매개 등온 증폭(dLig-LAMP)Article Published on 2022-04-052022-09-11 Journal: Mikrochimica Acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition alternative method appear approach arise binding colorimetric detection dLig-LAMP. DNA amplification False-positive hand induce isothermal amplification LAMP Loop-mediated isothermal amplification point-of-care PP Probe primer probe problem Pyrophosphate reverse transcription RT-LAMP SARS-CoV-2 selective selectivity Signaling Splint Splint R Ligase [DOI] 10.1007/s00604-022-05293-7 PMC 바로가기 [Article Type] Article
A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS표적화 가능한 '불량' 호중구 하위 집합인 [CD11b+DEspR+] 면역형은 급성 호흡 곤란 증후군(ARDS) 및 COVID-19-ARDS의 중증도 및 사망률과 관련이 있습니다Article Published on 2022-04-042022-09-11 Journal: Scientific Reports [Category] 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antibody Apoptosis ARDS arise assays association blocked Critical death detect dual dysregulated Endothelin Ex vivo expressing humanized identify IgG4 immunotype induce induction of apoptosis inhibitor inhibitors insufficiency internalization kill Ligand lung tissue MOF monocyte Monocytes Mortality NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps neutrophil function Neutrophils pathogenic Pathogens Patient peptide pleiotropic progression receptor respiratory distress Respiratory distress syndrome rhesus scRNA-seq severity syndrome Therapeutic approach tissue injury [DOI] 10.1038/s41598-022-09343-1 PMC 바로가기 [Article Type] Article
Diagnostic precision of local and World Health Organization definitions of symptomatic COVID-19 cases: an analysis of Mexico’s capitalShort communication Published on 2022-04-012022-10-05 Journal: Public health [Category] 진단, [키워드] Analysis arise calculated Confirmed Contact COVID-19 COVID-19 case COVID-19 pandemic determine diagnostic Epidemiologic surveillance epidemiological Evidence FIVE Government identify Local Mexico Mexico City objective pandemic Precision Result sensitivity specificity symptomatic symptomatic cases the WHO while WHO World Health Organization [DOI] 10.1016/j.puhe.2022.02.010 [Article Type] Short communication