TRPC6 inhibitor (BI 764198) to reduce risk and severity of ARDS due to COVID-19: a phase II randomised controlled trialOriginal research Published on 2023-08-062024-09-05 Journal: Thorax [Category] update2024, [키워드] ambulatory oxygen therapy ARDS assisted ventilation Critical care emergency medicine non-invasive ventilation [DOI] 10.1136/thorax-2022-219668 PMC 바로가기 [Article Type] Original research
Characteristics of hospitalized patients with SARS-CoV-2 infection during successive waves of the COVID-19 pandemic in a reference hospital in SpainArticle Published on 2022-10-172022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] age assisted ventilation Characteristics collected Comorbidities COVID-19 pandemic death delta variant demographic data died enrolled Examining FIVE hospital Hospitalized hospitalized patient incidence Infection intensive care unit medical records mortality rate outcome Patient receive SARS-COV-2 infection Spain successive wave suffered Symptoms the patient those who survived vaccination [DOI] 10.1038/s41598-022-22145-9 PMC 바로가기
Randomised trial to determine the effect of vitamin D and zinc supplementation for improving treatment outcomes among patients with COVID-19 in India: trial protocolArticle Published on 2022-08-292022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] all-cause mortality assisted ventilation baseline Biomarker Blood clinical trials commenced cough COVID-19 daily dose deficiency defined determine double-blind dysregulated Ethical approval ethical committee Ethics evaluate the effect Fever Final Follow-up hospital Hospital stay host responses India individual symptom Measures Micronutrient Mumbai nutrition occur outcome outcomes participant patients with COVID-19 peer-reviewed Placebo placebo-controlled trial positive individual preventive measure Primary outcome provided randomised recruited recruitment SARS-COV-2 infection secondary Shortness of breath Symptom Time to recovery Treatment outcome Trial trial protocol undergo vaccination was obtained zinc supplementation [DOI] 10.1136/bmjopen-2022-061301 PMC 바로가기 [Article Type] Article
Anti-neuronal antibodies against brainstem antigens are associated with COVID-19Article Published on 2022-08-112022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Affect AIFM1 antibody Antigen appear assisted ventilation Autoimmunity Brainstem Control controls Course COVID-19 patient COVID-19 patients DAB1 determine diagnostic Disabled Economy elevated Encephalitis epitope Epitopes finding foundation funding Germany Greifswald group help homolog hypothesised IgG IgG and IgM IgG level IgM implicated in both groups initiative intensive care Invasion long-COVID marker Medicine Microarray Mild Occurrence pathogenic pathway Patient peptide epitope predicted responsible SARS-CoV-2 serum severe disease severely ill patient significantly state Support SURF1 the disease therapeutic understanding university unlikely with COVID-19 [DOI] 10.1016/j.ebiom.2022.104211 [Article Type] Article
Outcomes of acute limb ischemia in COVID-19Research article Published on 2022-06-012022-10-05 Journal: Journal of vascular surgery [Category] 진단, [키워드] Acute limb ischemia acute renal failure acute respiratory syndrome analyses arterial thromboembolism assisted ventilation baseline Care caused classification cohort characteristics collected Comorbidities Comorbidity complications Consequences coronavirus coronavirus disease COVID-19 defined demographics determine develop diagnostic event events exacerbate Health hospitalized patient identify Infection inflammatory cascade Ischemia less limb mental health Mortality Myocardial infarction objective organization outcome Patient patient data patients with COVID-19 provide Respiratory failure Result SARS-CoV-2 Sepsis significantly significantly higher significantly more stroke the United State thrombosis variables was performed were used with COVID-19 worse prognosis [DOI] 10.1016/j.jvs.2022.04.038 [Article Type] Research article
RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemicArticle Published on 2022-02-012023-07-06 Journal: Thorax [Category] COVID19(2023년), [키워드] ARDS assisted ventilation COVID-19 Critical care Non invasive ventilation viral infection [DOI] 10.1136/thoraxjnl-2021-216904
Study of Clinical Outcome and Healthcare Modalities of COVID-19 Patients Treated With Remdesivir at a Tertiary Care Teaching HospitalInfectious Disease Published on 2022-01-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI 95% confidence interval Administered age All the patient analyzed approved assisted ventilation association Care Characteristics clinical Clinical outcome clinical outcomes Comorbidities Comorbidity conducted coronavirus country COVID-19 COVID-19 patient determine diabete difference Factor Gender Health health care modalities healthcare hospital hypertension Infection intravenously material modality number of comorbidity Odds ratio Oxygen requirement Patient patients protocol released Remdesivir required Result Retrospective study statistical statistically significant Still Teaching Tertiary the mean treated Treatment treatment for COVID-19 younger patient [DOI] 10.7759/cureus.21535 PMC 바로가기 [Article Type] Infectious Disease
Evaluation of new or repurposed treatments for COVID-19: protocol for the phase Ib/IIa DEFINE trial platformCOVID-19에 대한 신규 또는 용도 변경 치료제 평가: Ib/IIa상 DEFINE 시험 플랫폼 프로토콜Article Published on 2021-12-152022-09-11 Journal: BMJ Open [Category] 임상, [키워드] acceptance adaptive administration Analysis Appropriate approval Arm ARMS assisted ventilation caused changes in clinical trial Coagulation Cohort Community Complete computer COVID-19 COVID-19 therapy dependent on development during treatment effective Efficacy Ethics ethics committee EudraCT Evidence evidence of Experimental medicine exploratory Follow-up hospital Hospital stay hospitalised patient Infection Infectious diseases information initial mechanism mechanism of action Medicine MHRA National Health Service NEWS2 NHS Novel coronavirus Open-label Ordinal Scale oxygen Oxygen requirements participant Pathways Patient patient cohorts patient safety patients with COVID-19 peer-reviewed pharmacokinetic Pneumonia Pneumonitis positive present product protocol randomisation randomised Randomised Evaluation REC recovery recruited recruitment registration number research and development Research Ethics Research Ethics Committee respiratory medicine (see thoracic medicine) Safe SARS-CoV-2 score secondary Standard of care statistical analysis submitted Support Therapeutics therapy Thoracic Treatment treatment arm treatment period Trial trial platform variable Viral load viral-induced WHO ordinal scale [DOI] 10.1136/bmjopen-2021-054442 PMC 바로가기 [Article Type] Article
COVID-19 clinical phenotypes and short-term outcomes: differences between the first and the second wave of pandemic in ItalyObservational Study Published on 2021-12-012022-10-05 Journal: Expert review of respiratory medicine [Category] SARS, 임상, [키워드] acute respiratory distress analyzed ARDS assisted ventilation changed chronic condition Clinical characteristics Clinical features clinical outcomes clinical phenotype clinical risk consecutive patient coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient Critical care death rate disease help Intermediate RICU Italy laboratory result laboratory-confirmed medical treatment Multimorbidity outcome pandemic Patient patients hospitalized patients with ARDS phenotypic Pneumonia Respiratory Support retrospective second wave Stage survival syndrome the SARS-CoV-2 transfer Treatment triggering two group virus [DOI] 10.1080/17476348.2021.1960824 PMC 바로가기 [Article Type] Observational Study
COVID-19 in Saudi Patients With Sickle Cell Disease: A Retrospective Multi-Center StudyPediatrics Published on 2021-08-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Administered Admission Affect age Antibiotics Anticoagulant assisted ventilation Cell Chest condition COVID-19 determine diagnosis of COVID-19 discharged disease drugs ENhance evaluated females Fever Hospitalization intensive care Laboratory management medication Nasopharyngeal swab outcomes Patient patients Prevalence Prognosis protocols Result retrospective RT-PCR Saudi Arabia SCD Sickle Sickle cell disease steroid syndrome the patient virus VoC widespread [DOI] 10.7759/cureus.17238 PMC 바로가기 [Article Type] Pediatrics