Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of NeuronsArticle Published on 2022-12-202023-07-10 Journal: mBio [Category] COVID19(2023년), [키워드] astrocytes COVID-19 human iPSC-derived brain organoids Inflammation Innate immunity neuronal dysfunction. [DOI] 10.1128/mbio.02308-22 PMC 바로가기
Subtle vascular and astrocytic changes in the brain of coronavirus disease 2019 (COVID-19) patientsArticle Published on 2022-12-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome analysed Analysis AQP4 aquaporin 4 Astrocyte astrocytes Blood Brain brain blood vessels calculated CD31 Central nervous system change changes changes in co-expression collagen control patient controls coronavirus coronavirus disease COVID-19 COVID-19 cases COVID-19 patients decrease described endothelial fluorescent Fractal dimension GFAp immunohistochemistry Infection inflammatory signalling light microscopy lymphocyte membrane membranes microglial morphological change morphology Patient patients perivascular Protein reduced reduction SARS-CoV-2 SARS-COV-2 infection significantly increased Vascular vascular basement membranes. vessel [DOI] 10.1111/ene.15545 PMC 바로가기
The neurobiology of long COVIDReview Published on 2022-11-022023-07-10 Journal: Neuron [Category] COVID19(2023년), [키워드] astrocytes Autoimmunity blood-brain-barrier Cognitive impairment COVID-19 EBV hippocampal neurogenesis HSV Long COVID microglia Microvascular disease Myelin PAISs post-acute infection syndromes. SARS-CoV-2 [DOI] 10.1016/j.neuron.2022.10.006 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytesArticle Published on 2022-10-012022-11-16 Journal: Journal of neurochemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Alpha Alter Astrocyte astrocytes blockade Brain carbon metabolism cause change Cognitive impairment Confusion COVID-19 death evaluated Evidence evidenced Glucose Glutamine Glycolysis hamsters Hyperactivation Immunopathogenesis Impact in vitro in vivo Inflammatory response intranasally ketoglutarate Lung disease memory metabolomics neurological Neurological diseases neurological impairment Neuropathology neurotransmitter olfactory Protein proteomics proteomics. pyruvate reduction Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 synaptic Transmission viral replication [DOI] 10.1111/jnc.15679 PMC 바로가기
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variantsArticle Published on 2022-09-052022-11-16 Journal: Acta Neuropathologica Communications [Category] SARS, 변종, [키워드] acute phase acute respiratory syndrome astrocytes B.1.1.529 B.1.617.2 Brain olfactory bulb Cell CNS co-cultured coronavirus cortical COVID-19 Culture D614G days post infection Delta hamster hamsters in vitro in vivo in vivo models Infection inoculated interferon isolate mechanism microglia activation mucosa Neuroinflammation neuroinvasion Neuroinvasive Neurological complications Neuron neurotropic neurotropism neurovirulence neurovirulent occur olfactory omicron performed reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. shown the SARS-CoV-2 variant [DOI] 10.1186/s40478-022-01426-4 PMC 바로가기
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neurological symptoms. neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus [DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article
Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19혈액-뇌장벽 기능 장애 및 SARS-CoV-2 감염에 대한 감수성에서 노화의 역할: COVID-19의 신경학적 증상에 대한 영향Review Published on 2022-08-182022-09-11 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] addition age aging alleviate astrocytes barrier blood-brain barrier Brain caused cell type Central nervous system cerebrospinal fluid CNS Comorbidity Corona Corona virus COVID-19 COVID-19 patients Cytokine storm deaths described diabete diabetes distress dysfunction endothelial cells endothelial function expression profile Hospitalization Impact inducer inflammatory reaction inflammatory reactions Interaction interactome microglia Mitochondria mitochondrial Mitochondrial function mitochondrial functions morbidity and mortality neurological Neurological symptom Neurological symptoms neurons Neurovascular outcome patients pericytes Pneumonia present respiratory respiratory distress risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus suggested susceptibility target therapy treat with COVID-19 [DOI] 10.1186/s12987-022-00357-5 PMC 바로가기 [Article Type] Review
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking smoking. stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
Non-Productive Infection of Glial Cells with SARS-CoV-2 in Hamster Organotypic Cerebellar Slice CulturesArticle Published on 2022-06-032023-07-09 Journal: Viruses [Category] COVID19(2023년), [키워드] astrocytes Brain COVID-19 microglia Neuroinflammation organotypic culture. SARS-CoV-2 [DOI] 10.3390/v14061218 PMC 바로가기