Exploring the anti-SARS-CoV-2 main protease potential of FDA approved marine drugs using integrated machine learning templates as predictive toolsArticle Published on 2022-11-012022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] activity Activity atlas model Activity cliff Algorithm anti-SARS-CoV-2 approved Atla Biological camostat Compound COVID-19 COVID-19 pandemic Cresset data set docked drug drugs effective FDA field Field template FIVE flare group Holichondrin B inactive macromolecules Marine drugs. nafamostat outbreak Predictive protease Protein remained Repurposed drug responsible Safe SARS-CoV-2 Structure structures [DOI] 10.1016/j.ijbiomac.2022.09.086 PMC 바로가기
CASA: a comprehensive database resource for the COVID-19 Alternative Splicing AtlasArticle Published on 2022-10-202022-11-15 Journal: Journal of Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] affected alteration Analysis Atla cell line conditions COVID-19 database dataset Diseases drug-target interaction event events facilitate functional annotation help host cell human cell identify immune response IMPROVE Infectious disease mechanism mechanisms Organoid performed platform profile Protein protein expression provided Quantitative data regulate Regulatory Research resource RNA RNA-seq dataset severity splicing tissues transcriptional virus [DOI] 10.1186/s12967-022-03699-8 PMC 바로가기
Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3SARS-CoV-2에 대한 현재 이용 가능한 인간 중화 항체의 아틀라스 및 Omicron 하위 변이체 BA.1/BA.1.1/BA.2/BA.3에 의한 탈출Article Published on 2022-08-092022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Atla complex COVID-19 decreased activity Efficacy epitope facilitate G446S mutation human monoclonal antibodies Human monoclonal antibody human neutralizing antibodies Immune escape immune evasion lack mAb mAbs Mutation Neutralizing neutralizing activities neutralizing antibody Neutralizing assay neutralizing assays omicron Omicron BA.1 Omicron BA.1.1 Omicron BA.2 Omicron BA.3 provided RBD SARS-CoV-2 SARS-CoV-2 RBD sensitivity Seven the SARS-CoV-2 therapeutic Vaccine Vaccines variant variants [DOI] 10.1016/j.immuni.2022.06.005 PMC 바로가기 [Article Type] Article
Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular simulation analyses폐 선암과 결합된 코로나바이러스 질병 2019에 대한 에메틴의 잠재적 메커니즘 탐색: 생물정보학 및 분자 시뮬레이션 분석Article Published on 2022-06-222022-09-11 Journal: BMC Cancer [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Atla binding bioinformatics bioinformatics analyses BTK CCL20 conducted connectivity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cox proportional hazard DDP4 differentially expressed docking DPP4 drug drugs effective Emetine ENhance exhibited furin groups IL6 inhibit Intersection lack LDHA lung lung adenocarcinoma Map MD simulation MIF molecular molecular docking molecular dynamics Molecular simulation MPro network network pharmacology Patient performed potential mechanism potential mechanisms PRF1 Prognosis protease Replication replication of SARS-CoV-2 risk SARS-CoV-2 Screen screened SDK1 SERPING1 severe acute respiratory syndrome Coronavirus SLC6A4 target therapeutic target Transcriptome TRPA1 Tumor tumor immunity ZIC5 [DOI] 10.1186/s12885-022-09763-2 PMC 바로가기 [Article Type] Article
Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma카텝신 B는 폐 선암종을 가진 코로나바이러스 질병 2019 환자를 위한 잠재적인 치료 표적입니다Article Published on 2022-02-012022-09-11 Journal: Chemico-biological interactions [Category] 바이오마커, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Atla available data Basigin bioinformatics cancers cathepsin cathepsin B cause Cell coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CTSB database determine diagnosed with COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 drug therapy explain expressed expression Gene Expression Omnibus GEO global public health Hyperinflammatory Hyperinflammatory response identify Immune cell infiltration implicated lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mortality rate outcome Patient patients patients with COVID-19 positively correlated potential therapeutic target presenting Proinflammatory cytokine SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility the SARS-CoV-2 therapeutic target therapy for COVID-19 tissue upregulation [DOI] 10.1016/j.cbi.2022.109796 PMC 바로가기 [Article Type] Article
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung CancerArticle Published on 2022-02-012022-10-04 Journal: Inflammation [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 ACE2 expression acute respiratory syndrome affected angiotensin-converting enzyme 2 Atla Cell characteristic coronavirus Correlation analysis COVID-19 COVID-19 patient Critical dataset dysregulated effective therapy expression expressions FBP Folate-binding protein gp130 IL-6 IL6 increase in indicated Infection Inflammation Inflammatory response Inflammatory responses inverse correlation lesson Loss lung adenocarcinoma lung cancer lung tissue injury methotrexate Phosphorylation Protein qRT-PCR analysis repurposing rescued SARS-CoV-2 SARS-COV-2 infection similarity Spearman suggested transfected cells Treatment [DOI] 10.1007/s10753-021-01536-6 PMC 바로가기 [Article Type] Article
Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart심장 SARS-CoV-2 감염은 심장 내 전염증성 전사체 변화와 관련이 있습니다Article Published on 2022-01-292022-09-11 Journal: Cardiovascular Research [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] adverse outcome Analysis Atla Autopsy cardiac Cardiac infection Cardiac signature matrix caused cDNA Cell consequence COVID-19 Cytometry Deceased DEGs destruction Diagnosis differentially expressed gene downregulated Effects endothelial Endothelial cell endothelial cells fraction Gene ontology GO term heart heart tissue ICAM1 identify IFI44L Immune cell Immune cell infiltration immune response Immunofluorescent staining immunohistochemistry In situ hybridization Increased Infection interferon interferon pathway investigated MACE marker massive molecular MYPN no difference NPPB paracrine Pathomechanism positive pro-inflammatory pro-inflammatory gene expression q-value Quantitative reveal RNA-Seq RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequencing data signature matrix single-cell dataset staining tissue transcriptomic alteration TRIM25 upregulated Viral Viral protein virus virus load was performed while [DOI] 10.1093/cvr/cvab322 PMC 바로가기 [Article Type] Article
DrugDevCovid19: An Atlas of Anti-COVID-19 Compounds Derived by Computer-Aided Drug DesignDrugDevcovid19 : 컴퓨터 보조 약물 설계에 의해 유래 된 항 코비드 -19 화합물의 아틀라스Review Published on 2022-01-212022-08-31 Journal: Molecules [Category] 신약개발, 치료제, [키워드] analyses analyzed Atla bioinformatics Compound computer-aided drug design COVID-19 COVID-19 therapeutics database docking drug drug design facilitate feature Neck organized outbreak performed SARS-CoV-2 structures subsequent target protein these compounds valuable resource [DOI] 10.3390/molecules27030683 PMC 바로가기 [Article Type] Review
T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutationsT-CoV: SARS-CoV-2 돌연변이의 영향을 받는 HLA-펩티드 상호작용의 종합 포털AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, [키워드] (alpha Affect affected affinity alleles Alpha Alter alteration Atla atlas binding affinities CD4 T-cell CD8 clinician COVID-19 Delta dependent on Diversity Epitopes evade example Genotype help highlight HLA HLA allele HLA alleles HLA class I HLA molecule HLA molecules HLA-B In silico methods individual Infection Interaction peptide peptides portal predict researcher responses SARS-CoV-2 mutation SARS-CoV-2 mutations severity susceptibility T cell T cell epitopes T-cell T-cell responses variant variants variants of SARS-CoV-2 viral peptide viral peptides virus virus variant were assessed Wuhan [DOI] 10.1093/nar/gkab701 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
The 2022 Nucleic Acids Research database issue and the online molecular biology database collectionAcademicSubjects/SCI00010 Published on 2022-01-072022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] acid article Atla Biology CAZy Collection ConsensusPathDB COVID-19 database described Genomics Human include issue Major manuscript metabolism microbial Molecular biology New notable nucleic acid post-translational modifications Protein Proteins resource resources SARS-CoV-2 Structure target UCSC Genome Browser viral genome website [DOI] 10.1093/nar/gkab1195 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010