Potential anti-mpox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatmentsArticle Published on 2023-03-092023-06-10 Journal: The Journal of Infectious Diseases [Category] 원숭이두창, [키워드] Antiviral atovaquone dihydroorotate dehydrogenase mefloquine molnupiravir mpox pan-Orthopoxvirus. [DOI] 10.1093/infdis/jiad058
Proguanil and atovaquone use is associated with lower colorectal cancer risk: a nationwide cohort study프로구아닐과 아토바쿼논 사용은 대장암 위험 감소와 관련이 있다: 전국적인 코호트 연구Article Published on 2022-11-102024-08-01 Journal: BMC Medicine [Category] 말라리아, [키워드] atovaquone Chemoprevention Colorectal cancer family history proguanil [DOI] 10.1186/s12916-022-02643-3 PMC 바로가기
Computational repurposing approach for targeting the critical spike mutations in B.1.617.2 (delta), AY.1 (delta plus) and C.37 (lambda) SARS-CoV-2 variants using exhaustive structure-based virtual screening, molecular dynamic simulations and MM-PBSA methods철저한 구조 기반 가상 스크리닝, 분자 역학 시뮬레이션을 사용하여 B.1.617.2(델타), AY.1(델타 플러스) 및 C.37(람다) SARS-CoV-2 변이체에서 중요한 스파이크 돌연변이를 타겟팅하기 위한 전산 용도 변경 접근 방식 및 MM-PBSA 방법Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 approach Area atovaquone AY.1 B.1.617.2 binding affinity binding site candidate causative agent complex complexes Compound contagious contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Delta delta variant Delta variants docking result docking results drug Drug repurposing drug-likeness drugs eight enzyme FDA approved drug FDA approved Drugs followed by genomic help heparin highest binding affinity Host hydrogen Hydrogen bond identify in silico inhibiting inhibitor inhibitors interact Interaction interactions Lambda Ligand MD simulation MD simulations molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics morbidity and mortality mortality rates Mutation mutations Praziquantel Protein Proteins RBD Receptor-binding domain reported Research researcher residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation spike spike mutation Spike protein stability surface surface area targets the receptor-binding domain the spike protein variant variants variants of concern viral cell Virtual screening VoC was done was performed wild type Wuhan Wuhan, China [DOI] 10.1016/j.compbiomed.2022.105709 PMC 바로가기 [Article Type] Article
Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjectsArticle Published on 2022-07-142024-08-28 Journal: Journal of Travel Medicine [Category] 말라리아, [키워드] atovaquone Drug–drug interactions ketoconazole Malaria chemoprophylaxis malarone pharmacokinetics proguanil
Presence of Phylloquinone in the Intraerythrocytic Stages of Plasmodium falciparumarticle Published on 2022-04-302024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] atovaquone isoprenoid malaria naphthoquinone phylloquinone Phytol phytyl Plasmodium [Article Type] article
Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In VitroArticle Published on 2021-12-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] addition Antiviral approach approaches atovaquone berberine berberine chloride can be used Cell Compound conducted coronavirus disease drug effective highlight human lung cells Infection inhibit SARS-CoV-2 inhibitor Interaction pandemic Pandemics Prevent reduce RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine screened virion virus viruses while [DOI] 10.3390/v13122437 PMC 바로가기 [Article Type] Article
Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of ConcernSARS-CoV-2 및 우려되는 신흥 변종에 대한 항균 약물 Atovaquone의 항바이러스 가능성Article Published on 2021-11-122022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 Administered Alpha antimicrobial Antiviral antiviral activity atovaquone atovaquone/proguanil Azithromycin benefit Beta Calu-3 Canada Cell culture cellular Chemoprophylaxis children clinical trial Combination Concentration concern coronavirus COVID-19 Delta variants dependent on disrupt drug Drug repurposing epithelial cells Evidence expressing expression FDA-approved drug human lung in vitro Infection inhibit initiated Interaction malaria malarone medication membrane fusion other variant other variants Patient Potential primary human airway proguanil receptor reduced Replication replication of SARS-CoV-2 retained Safe SARS-CoV-2 Spike protein the spike protein The United States TMPRSS2 trials United States variants virus while [DOI] 10.1021/acsinfecdis.1c00278 PMC 바로가기 [Article Type] Article
Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells인간 세포에서 SARS-CoV-2 복제를 늦추는 용도 변경 약물의 발견Research Article Published on 2021-09-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 바이오마커, 신약개발, [키워드] addition amodiaquine atovaquone Author bedaquiline candidate cell types COVID COVID-19 COVID-19 vaccine COVID-19 vaccines drug Drug repurposing ebastine effective evaluated FDA-approved drugs help hepatocyte hepatocytes human cell human cells Immunity infected cells Infection kidney Liver damage luciferase LY2835219 manidipine measure nLuc panobinostat patients with COVID-19 performed Protein Proteinuria proximal tubule proximal tubule cell proximal tubule cells reduced replication Replication reported Repurposed drug Repurposed drugs required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Screen Spike protein Support the disease the Spike Therapeutics treat treated Treatment utility Vero Cell Vero cells Viral Viral load virus virus replication Vitamin D3 [DOI] 10.1371/journal.ppat.1009840 PMC 바로가기 [Article Type] Research Article
Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in MalariaArticle Published on 2021-03-182024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] 4-nitrobenzoate antimalarial agents atovaquone Biosynthesis malaria oxygen levels Plasmodium falciparum Ubiquinone
Coronavirus disease 2019 drug discovery through molecular dockingResearch Article Published on 2020-06-032022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] Acetate acute respiratory syndrome antimalarial antiparasitic drug antivirals atovaquone communicable coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 death disease docking drug Drug discovery effective growth Infection inhibitory molecular docking pandemic reported SARS-CoV-2 Spread therapeutic agent Treatment Vaccine Virtual screening World Health Organization [DOI] 10.12688/f1000research.24218.1 PMC 바로가기 [Article Type] Research Article