The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males
TLR3의 다형성 L412F는 자가포식을 억제하고 남성에서 심각한 COVID-19의 표지자입니다
Article
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Analysis
association
autoantigen
autoimmune disorder
Autoimmune disorders
autophagosome
autophagy
autophagy pathways
bafilomycin
clinical trial
clinical trials
co-morbidity
Cohort
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
COVID-19 patients
demonstrated
Diseases
Frequency
HEK293 cell
HEK293 cells
HLA
HLA haplotype
Hydroxychloroquine
Impaired
increases in
Infectious diseases
inhibit
L412F
male
males
marker
mechanism
morbidity
Necrosis
Plasmid
poly(I:C)
polymorphism
provide
Rapamycin
rationale
receiver operating characteristic
receptor
reduced
respiratory
risk
severe acute respiratory syndrome Coronavirus
severe COVID-19
severity
shown
statistically significant
stimulated
sub-cohort
survival
TLR3
TNFα
transfected with
treated
Tumor
tumor necrosis
tumor necrosis factor
[DOI] 10.1080/15548627.2021.1995152 PMC 바로가기 [Article Type] Article
[DOI] 10.1080/15548627.2021.1995152 PMC 바로가기 [Article Type] Article