ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formationCOVID-19 바이러스 SARS-CoV-2의 ORF3a는 자가용해소체 형성에 필요한 SNARE 복합체의 HOPS 복합체 매개 조립을 차단합니다Article Published on 2021-02-222022-09-11 Journal: Developmental cell [Category] SARS, 유전자 메커니즘, [키워드] accumulation autophagy autophagy activity block cause cellular complex COVID-19 COVID-19 virus demonstrated DMV evade fusion HOPS impair inhibit interact invading pathogens lysosomal lysosome Lysosomes mechanism ORF3a Pathogens Protein provide Replication required resulting reveal SARS virus SARS-CoV SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection SNAP29 SNARE SNARE complex STX17 Surveillance treat virus infection viruses VPS39 [DOI] 10.1016/j.devcel.2020.12.010 PMC 바로가기 [Article Type] Article