Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes말라리아 관련 유전자에 의해 예시된 적응형 다형성의 세 가지 특징Article Published on 2021-04-132024-08-08 Journal: Molecular Biology and Evolution [Category] 말라리아, [키워드] balancing selection erythrocyte human population genomics malaria Positive selection selection scan [DOI] 10.1093/molbev/msaa294 PMC 바로가기
Genome-Wide Analysis of the Malaria Parasite Plasmodium falciparum Isolates From Togo Reveals Selective Signals in Immune Selection-Related Antigen Genes토고에서의 말라리아 기생충 플라스모디움 팔시파룸 분리주의 게놈 전반 분석은 면역 선택 관련 항원 유전자에서 선택적 신호를 드러낸다Original Research Published on 2020-10-232024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] balancing selection directional selection genomes Immunity Plasmodium falciparum Togo [DOI] 10.3389/fimmu.2020.552698 PMC 바로가기 [Article Type] Original Research
Expression estimation and eQTL mapping for HLA genes with a personalized pipeline개인화된 파이프라인으로 HLA 유전자에 대한 발현 추정 및 eQTL 매핑Research Article Published on 2019-04-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Human Leukocyte Antigens abundance adaptive aligned allele antibody applied approach approaches balancing selection biases carried Causality cause choice classical HLA loci dataset datasets develop difficulty disease disease phenotype disease susceptibility Diseases Divergence downstream analyses downstream analysis DPA1 DPB1 DQA1 DQB1 DRB1 eQTL eQTL mapping eQTLs estimate estimates evaluate explain expressed expression expression level expression levels Gene Expression Genotype genotypes help HLA HLA allele HLA alleles HLA gene HLA genes HLA region HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA HLA-DRB1 Human Leukocyte Antigens immune immune adaptive response influence information leukocyte Lineage lineages loci mapping nine organism P-value p-values paralogues phenotype Phenotypes predisposition problem qPCR quantification reference genome Regulation Regulatory remained RNA RNA-Seq sequence susceptibility target Transcriptome Variation [DOI] 10.1371/journal.pgen.1008091 PMC 바로가기 [Article Type] Research Article
Association mapping desiccation resistance within chromosomal inversions in the African malaria vector Anopheles gambiaearticle Published on 2019-03-312024-09-01 Journal: Molecular Ecology [Category] 말라리아, [키워드] aridity tolerance balancing selection Local adaptation Recombination [Article Type] article
Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria ExposureArticle Published on 2019-03-072024-08-28 Journal: The American Journal of Human Genetics [Category] 말라리아, [키워드] Africa Approximate Bayesian computation balancing selection farmers malaria rainforest hunter-gatherers sickle mutation.
Blood parasites shape extreme major histocompatibility complex diversity in a migratory passerinearticle Published on 2018-06-302024-09-01 Journal: Molecular Ecology [Category] 말라리아, [키워드] Acrocephalus schoenobaenus allele frequency changes Avian malaria balancing selection copy number variation major histocompatibility complex diversity sedge warbler [Article Type] article
An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application to Streptococcus pneumoniae계절적 항생제 사용 하에서 항생제 내성의 빈도를 예측하기 위한 진화 모델과 폐렴구균에 대한 적용Article Published on 2017-05-312024-08-01 Journal: Proceedings of the Royal Society B: Biological Sciences [Category] 폐렴구균 감염증, [키워드] adaptation antimicrobial resistance balancing selection drug resistance fluctuating selection Microbiology [DOI] 10.1098/rspb.2017.0679 PMC 바로가기
Environmental Correlation Analysis for Genes Associated with Protection against Malaria말라리아 방어와 관련된 유전자에 대한 환경 상관 분석Article Published on 2016-05-062024-08-12 Journal: Molecular Biology and Evolution [Category] 말라리아, [키워드] balancing selection environmental correlation analysis Local adaptation malaria [DOI] 10.1093/molbev/msw004 PMC 바로가기
Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex알파인 아이벡스의 주요 조직 적합성 복합체에서 국내 염소 생성 변이로부터의 이입Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive allele alleles Alpine ibex balancing selection breed carried chromosomal region Clustering coding coding regions Defense Evidence functional gene genetic diversity Genetic polymorphism genetic variability Genetic variation genomes goat Haplotype haplotypes heterozygosity histocompatibility histocompatibility complex homozygous Ibex identify immune system individual introgression investigated involved loci locus Major major histocompatibility complex mechanism MHC non-coding region pathogen Pathogens polymorphism populations provide Research restored sequence sequenced Sequencing signature SNP SNP allele SNP alleles species Support susceptible thought two allele Two alleles Variation [DOI] 10.1371/journal.pgen.1004438 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis of Selection on the Malaria Parasite Plasmodium falciparum in West African Populations of Differing Infection Endemicity서아프리카의 감염 풍토가 다른 인구에서 말라리아 기생충 플라스모디움 팔시파룸에 대한 선택의 유전체 전반 분석Article Published on 2014-06-182024-08-13 Journal: Molecular Biology and Evolution [Category] 말라리아, [키워드] balancing selection directional selection Immunity pathogen population genomics Transmission [DOI] 10.1093/molbev/msu106 PMC 바로가기