Delivery Strategies of siRNA Therapeutics for Hair Loss TherapyReview Published on 2024-07-112024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] barrier delivery design principle Hair loss siRNA strategic research framework [DOI] 10.3390/ijms25147612 PMC 바로가기 [Article Type] Review
Existing Barriers Faced by and Future Design Recommendations for Direct-to-Consumer Health Care Artificial Intelligence Apps: Scoping ReviewReview Published on 2023-12-182024-09-05 Journal: Journal of Medical Internet Research [Category] update2024, [키워드] app application Applications Apps artificial intelligence barrier barriers consumer consumers design Direct to consumer DTC Health care implementation medical review methodology Review methods scoping [DOI] 10.2196/50342 PMC 바로가기 [Article Type] Review
Opportunistic etiological agents causing lung infections: emerging need to transform lung-targeted deliveryReview Article Published on 2022-12-262024-09-04 Journal: Heliyon [Category] 대상포진, [키워드] antimicrobial agents barrier Etiological agents Infection Inhalable drug lung pulmonary delivery [DOI] 10.1016/j.heliyon.2022.e12620 PMC 바로가기 [Article Type] Review Article
Perspectives of healthcare providers on implementation of long-acting cabotegravir plus rilpivirine in US healthcare settings from a Hybrid III Implementation-effectiveness study (CUSTOMIZE)Article Published on 2022-09-012022-11-15 Journal: Journal of the International AIDS Society [Category] 치료제, [키워드] acceptability AIDS antiretroviral Antiretroviral therapy appropriateness assessment barrier baseline change clinics conducted COVID-19 pandemic eight evaluated feasibility finding FIVE foundation Health healthcare Healthcare provider HIV-1 hybrid implementation injection Intervention maintain Measures Month MOST Nurse occurred outcome Pain participant Patient Physicians positive Program Sustainability proportion Quantitative regimen reported single-arm sustainability total score Treatment [DOI] 10.1002/jia2.26003 PMC 바로가기
Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19혈액-뇌장벽 기능 장애 및 SARS-CoV-2 감염에 대한 감수성에서 노화의 역할: COVID-19의 신경학적 증상에 대한 영향Review Published on 2022-08-182022-09-11 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] addition age aging alleviate astrocytes barrier blood-brain barrier Brain caused cell type Central nervous system cerebrospinal fluid CNS Comorbidity Corona Corona virus COVID-19 COVID-19 patients Cytokine storm deaths described diabete diabetes distress dysfunction endothelial cells endothelial function expression profile Hospitalization Impact inducer inflammatory reaction inflammatory reactions Interaction interactome microglia Mitochondria mitochondrial Mitochondrial function mitochondrial functions morbidity and mortality neurological Neurological symptom Neurological symptoms neurons Neurovascular outcome patients pericytes Pneumonia present respiratory respiratory distress risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus suggested susceptibility target therapy treat with COVID-19 [DOI] 10.1186/s12987-022-00357-5 PMC 바로가기 [Article Type] Review
Neuro-Axonal Damage and Alteration of Blood-Brain Barrier Integrity in COVID-19 PatientsCOVID-19 환자의 신경-축삭 손상 및 혈액-뇌 장벽 무결성의 변경Article Published on 2022-08-102022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] absence alteration ARDS ARDS patient ARDS patients barrier Biomarker Blood blood-brain barrier CNS COVID-19 COVID-19 patient COVID-19 patients CSF damage ddPCR detectable discharge disease severity enzyme healthy donor healthy donors Hospitalization integrity involved light chain long-COVID matrix matrix metalloproteinases metalloproteinase MMPs neuro-COVID neurofilament neurofilament light chain Neurological symptom Neurological symptoms NfL Patient plasma plasma samples SARS-CoV-2 RNA SARS-CoV-2 RNA detection Zinc zymography zymography. [DOI] 10.3390/cells11162480 PMC 바로가기 [Article Type] Article
Mixed-methods process evaluation of a residence-based SARS-CoV-2 testing participation pilot on a UK university campus during the COVID-19 pandemicCOVID-19 전염병 동안 영국 대학 캠퍼스의 거주 기반 SARS-CoV-2 테스트 참여 파일럿의 혼합 방법 프로세스 평가Article Published on 2022-08-022022-09-11 Journal: BMC Public Health [Category] SARS, 변종, [키워드] acute respiratory syndrome coronavirus analysed Asymptomatic barrier collected communication Complex interventions complexity conducted convenience coronavirus 2 COVID-19 COVID-19 pandemic delta variant determine Efficiency Escalation ethics committee facilitated facilitator facilitators Factor faculty Frequency group help identify Impact implementation Intervention Isolation lack majority management mapped measure Medicine Mental Mixed-methods monitoring MOST National Normalisation opportunity outbreak pandemic participant Participation Perceived Process process evaluation Protective Public public health qualitative data Quantitative data reduction in registration number Regular Research Ethics respiratory Saliva SARS-CoV-2 SARS-CoV-2 testing Science Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly social distancing Support Testing universities university virus [DOI] 10.1186/s12889-022-13792-8 PMC 바로가기 [Article Type] Article
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance렘데시비르 내성 SARS-CoV-2의 체외 선택은 내성에 대한 높은 장벽을 보여줍니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] 50% effective concentration active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 barrier coronavirus in vitro increase in introduced Lineage Nsp12 Nsp12 polymerase nsp12 protein passage polymerase Protein remained Remdesivir resistance SARS-CoV-2 SARS-CoV-2 virus Selection [DOI] 10.1128/aac.00198-22 PMC 바로가기 [Article Type] Article
Patient perspectives on window of opportunity clinical trials in early-stage breast cancer초기 유방암에서 임상 시험 기회의 창에 대한 환자의 관점Article Published on 2022-07-012022-09-11 Journal: Breast cancer research and treatment [Category] 임상, [키워드] absence altruism Analysis anti-cancer treatment approach barrier benefit Breast Breast cancer Cancer clinic clinical clinical trial clinical trials contribute COVID-19 COVID-19 pandemic Decision-making desire diagnosed Diagnosis drug Enrollment Factor family fitness Hope hypothetical identify increasingly indicated offered oncology participant Participation Patient Patient perspectives performed Perspective positive attitude receive recruited Research Side effect Side effects standard treatment therapy Treatment Trial weighed window Window of opportunity. women [DOI] 10.1007/s10549-022-06611-6 PMC 바로가기 [Article Type] Article
Feasibility and lessons learned on remote trial implementation from TestBoston, a fully remote, longitudinal, large-scale COVID-19 surveillance study완전 원격, 종단, 대규모 COVID-19 감시 연구인 TestBoston에서 원격 시험 구현에 대한 타당성 및 교훈Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] Accessibility adaptive Adults age Antibody testing approach Asian assigned barrier Biomedical research Birth black Blood Boston clinical study clinical trial Cohort cohorts Community connection contribute COVID-19 COVID-19 infection COVID-19 pandemic Critical Data quality demographic groups engage Engagement enrolled Enrollment female greater imperative implementation IMPROVE individual initial Intensive Investment longitudinal Lower Massachusett medical system nasal swab offer Older paradigm shift participant Participation Patient Prevalence promote provided recruited recruitment reduce reducing remote reported required Research researcher retention risk factor Risk factors robust RT-PCR SARS-CoV-2 RT-PCR scientific rigor Sex study visit Support Surveillance Symptom Trial white [DOI] 10.1371/journal.pone.0269127 PMC 바로가기 [Article Type] Article