Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteasesArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome AGT Anacardium Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral drug apigenin Biflavonoid biological activity Calu-3 Cell clinical benefit coronavirus COVID-19 dose-dependent manner humoral immune response indicated inhibit investigated Lineage M pro monomer Papain-like protease pro-inflammatory protease SARS-CoV-2 SARS-CoV-2 replication Structure susceptible TNF-α tumor necrosis factor-alpha Type II pneumocyte Vaccines variants of concern [DOI] 10.1016/j.ijbiomac.2022.09.204 PMC 바로가기
Biflavonoids from Rhus succedanea as probable natural inhibitors against SARS-CoV-2: a molecular docking and molecular dynamics approachSARS-CoV-2에 대한 가능한 천연 억제제로서의 Rhus succedanea의 비플라보노이드: 분자 도킹 및 분자 역학 접근Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral activity approach Biflavonoid biflavonoids binding affinities binding affinity binding mode binding modes binding site Bioflavonoid catalytic catalytic site complexes Compound conformational coronavirus COVID-19 drug Drug development drugs effective vaccine Effective vaccines enzyme fluctuations highlight human population hydrophilic hydrophobic in viral in vitro in vivo inhibitor initial Interaction less molecular molecular docking molecular dynamic simulation molecular dynamic simulations molecular dynamics Molecular dynamics simulation molecular interaction MPro Mpro protein outbreak Panic protease provide Replication reported researcher residues Rhus Rhus succedanea RNA viruses Safe SARS-CoV-2 SARS-CoV-2 Mpro therapeutic threat unavailability viral replication virus worldwide pandemic [DOI] 10.1080/07391102.2020.1858165 PMC 바로가기 [Article Type] Article
In vitro testing and computational analysis of specific phytochemicals with antiviral activities considering their possible applications against COVID-19Research article Published on 2022-02-012022-10-05 Journal: South African Journal of Botany [Category] 신약개발, 치료제, [키워드] Analysis Anti-inflammatory antioxidant Antioxidative antiviral activity Antiviral products antiviral property AutoDock Biflavonoid biflavonoids binding affinity biological activity calculate candidate Characteristics Chinese coefficient Compound compounds computational analysis COVID-19 docking docking score drug-likeness Effect electrostatic examined Features free radical identify in vitro Inflammation Interaction investigated LPS macrophages molecular MPro Partition proinflammatory mediator quantum SARS-CoV-2 scavenging selected stimulated suggested tested the SARS-CoV-2 virus thermodynamic was performed [DOI] 10.1016/j.sajb.2022.02.009 [Article Type] Research article
Insights Into Amentoflavone: A Natural Multifunctional BiflavonoidPharmacology Published on 2021-12-222022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity addition amentoflavone anti-cancer Anti-inflammatory anti-SARS-CoV-2 Biflavonoid binding Bioavailability biological activities biological activity cancers drug delivery ERK Extracellular in silico Approach insight metabolism molecular docking molecular mechanism molecular target multifunctional Musculoskeletal natural NF-κB nuclear protease RBD RdRP Receptor binding domain recorded Regulation Research RNA-dependent RNA polymerase SARS-CoV-2 Selaginella tamariscina signaling pathway Spike protein therapeutic [DOI] 10.3389/fphar.2021.768708 PMC 바로가기 [Article Type] Pharmacology
Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant ActivityArticle Published on 2018-12-112023-08-30 Journal: Molecules [Category] E형 간염, [키워드] Selaginella helvetica antioxidant activity Biflavonoid HPLC Ionic liquids response surface methodology ultrasound extraction [DOI] 10.3390/molecules23123284 PMC 바로가기 [Article Type] Article