Virological response to nucleos(t)ide analogues treatment in chronic hepatitis B patients is associated with Bacteroides -dominant gut microbiomeArticle Published on 2024-04-062024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] Bacteroides bile acid fibrosis HBV microbiota [DOI] 10.1016/j.ebiom.2024.105101 PMC 바로가기 [Article Type] Article
Platycodi Radix Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse ModelArticle Published on 2024-03-202024-09-05 Journal: Nutrients [Category] update2024, [키워드] bile acid cholesterol non-alcoholic fatty liver disease (NAFLD) obesity Platycodi Radix Platycodon grandiflorum proteomics [DOI] 10.3390/nu16060893 PMC 바로가기 [Article Type] Article
Bile acid restrained T cell activation explains cholestasis aggravated hepatitis B virus infectionArticle Published on 2022-09-012023-06-12 Journal: FASEB journal : official publication of the Federa [Category] B형 간염, [키워드] bile acid Hepatitis B virus SOCE T cell activation [DOI] 10.1096/fj.202200332R
Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into HepatocytesArticle Published on 2022-06-092023-06-13 Journal: Viruses [Category] B형 간염, [키워드] bile acid HBV Infection Mutation NTCP PreS1 receptor transporter [DOI] 10.3390/v14061259 PMC 바로가기
Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patientsResearch article Published on 2022-06-012022-10-05 Journal: Metabolism: clinical and experimental [Category] 바이오마커, 진단, 치료기술, [키워드] alteration Analysis analyzed arachidonic acid artificial intelligence bile acid cause clinical decision COVID-19 COVID-19 infection disease Diseases healthy subject healthy subjects healthy volunteers highlight Hospitalized hospitalized patient Host identify immunological responses IMPROVE Inflammation Interaction involved Lipid lipid metabolism Lipidomics machine machine learning machine learning algorithm notable parameter pathophysiology Patient patients patients hospitalized Phosphatidylcholine quantified reported Result secondary bile acid serum the healthy viral infection was performed [DOI] 10.1016/j.metabol.2022.155197 [Article Type] Research article
Sex differences in global metabolomic profiles of COVID-19 patientsCOVID-19 환자의 글로벌 대사 프로필의 성별 차이Article Published on 2022-05-142022-09-11 Journal: Cell Death & Disease [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료제, [키워드] amino acids Analysis aromatic amino acids Asymptomatic disease bile acid Biomarker caused change changes in clinical parameter controls coronavirus coronavirus disease correlation correlations COVID-19 COVID-19 patient COVID-19 patients death demonstrated disease examined female patient groups identification involved knowledge leads lipid metabolism male metabolic pathway metabolic pathways metabolism metabolomic Mortality pathway Patient pentose performed profile profiles researcher robust SARS-CoV-2 serum samples severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe symptom severe symptoms Sex Sex difference sexual dimorphism statistical analysis susceptible Symptom target therapeutic target therapeutic targets treat Tryptophan tyrosine uninfected [DOI] 10.1038/s41419-022-04861-2 PMC 바로가기 [Article Type] Article
Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool Research Published on 2022-04-202022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] addition adipose Amino acid amino acid metabolism Analysis applied baseline benefit bile acid change changes clinical parameter Concentration control group correlated Critical derivative dietary change disease Effect Endpoint Exercise intervention Fatty liver Glucose highlight Human identify Intervention intervention group Lipid Liver disease maximum oxygen consumption mechanism metabolic pathway metabolite metabolomics NAFLD participant participated Patient performed plasma profile provided Randomized significantly Stool subject tissue Urine Waist circumference was used weight loss [DOI] 10.1038/s41598-022-10481-9 [Article Type] Research
Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile AcidsArticle Published on 2022-02-042023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] bile acid cholesterol CYP7A1 ERK FGF21 Taurine [DOI] 10.3390/ijms23031793 PMC 바로가기 [Article Type] Article
Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients임상 및 항체 특성은 중증 및 비중증 SARS-CoV-2 환자의 다양한 특징을 나타냅니다.Research Article Published on 2022-02-022022-09-10 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 adenosine adenosine deaminase analyzed antibodies antibody Antibody detection Antibody Response Antibody responses benefit bile acid binding C-reactive protein Characteristics clinical Clinical features clinical information collected contribute correlated COVID-19 COVID-19 case COVID-19 pandemic COVID-19 patient CTD cytokine Cytokines D-dimer domain domains elevated FcγRIIb Fisher’s exact test future therapeutic Ig isotypes IgG subclasses IgG1 IgG3 IL-6 IL-8 immune response investigated IP-10 LDH lymphocyte Lymphocyte count Mann–Whitney U test MCP-1 MCP-3 MIG neutrophil neutrophil count non-severe group NTD Patient patients preventive measure preventive measures procalcitonin Prognosis provide RBD RBD-ACE2 RBM receptors Result SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 spike protein serum sample serum samples severe group Severe patient significantly specificity Spike protein supplementary material Treatment [DOI] 10.1186/s40249-022-00940-w PMC 바로가기 [Article Type] Research Article
Metabolomics study of COVID-19 patients in four different clinical stages4 가지 임상 단계에서 Covid-19 환자의 대사체 연구Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] (COronaVIrus Disease 2019) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Analysis Asymptomatic disease bile acid bile acids biological pathway Biomarker Biomarkers change Clinical outcome Clinical stage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 illness COVID-19 patient Deceased defined diagnose disease early stage fatty acids Final groups help hospital hospital discharge hospitalized patient hospitalized patients HPLC Human individual Infection information involved ketone ketone bodies mass spectrometry metabolism metabolite metabolomics Mild Mild disease negative control omeprazole outcome pandemic Patient patients plasma plasma sample plasma samples positive patient Potential biomarker potential biomarkers predict produced Prognosis purines respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe disease subsequent Tryptophan viral infection with mild disease [DOI] 10.1038/s41598-022-05667-0 PMC 바로가기 [Article Type] Article