Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in people living with HIVHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 안전성 및 면역원성Observational Study Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] adverse event age Analysis binding domain booster dose CD4 CD4 count CD4 counts Cell COVID-19 declined Efficacy enrolled evaluated Factor Frequency Gender geometric GMT healthy control healthy controls HIV humoral humoral immune response IgG immune immune response Immunocompromised in both groups inactivated Inactivated vaccine less MBC memory B occurred Patient PLWH predicted prospective observational study reduced remained reported response responses robust Safety SARS-CoV-2 SARS-CoV-2 vaccine Serious Adverse Event Seven significantly vaccination Viral load with HIV [DOI] 10.1080/22221751.2022.2059401 PMC 바로가기 [Article Type] Observational Study
Immunogenicity and reactogenicity after heterologous prime-boost vaccination with CoronaVac and ChAdox1 nCov-19 (AZD1222) vaccinesCoronaVac 및 ChAdox1 nCov-19(AZD1222) 백신으로 이종 프라임-부스트 백신 접종 후 면역원성 및 반응성Article Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, 진단, [키워드] 95% CI 95% confidence interval Administered age age and sex antibody assigned AZD1222 binding domain booster dose Care ChAdOx1 nCoV-19 Cohort cohorts Combination Concentration control group CoronaVac COVID-19 COVID-19 pandemic effective elicited enrolled finding geometric mean ratio GMR Health Heterologous heterologous prime-boost homologous immune response immunogenicity indicated mass participant primary endpoint prime-boost interval RBD reactogenicity robust Safe the median vaccination Vaccine vaccine administration vaccine combination. while [DOI] 10.1080/21645515.2022.2052525 PMC 바로가기 [Article Type] Article
Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replicationArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] added antibiotic antimalarial Antiviral approved binding domain Bruton tyrosine kinase inhibitors China claimed contagious Control country COVID-19 pandemic Dependent disease domain drug drug design FDA in viral in-depth analysis increase Infection inhibiting inhibitor Interaction interfere M pro MD simulation number of infected outbreak Papain Population protease provide Psychological distress quinoline based FDA approved Drugs. RBD Remdesivir Replication required resource RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 selected Spike protein spread to target Vaccines viral entry viral replication Virtual screening [DOI] 10.1080/07391102.2021.1913228 PMC 바로가기
Antibody and T-cell responses by ultra-deep T-cell receptor immunosequencing after COVID-19 vaccination in patients with plasma cell dyscrasiasArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] 진단, [키워드] age anti-CD38 antibodies antibody Antibody Response Antibody testing antibody titres Antigen binding domain BNT162b2 breadth Cell comparable coronavirus disease correlated COVID-19 COVID-19 vaccination demonstrated detectable dose dyscrasia elicit Genome healthy humoral immune immunization Immunocompromised Immunoglobulin Increasing initial Intervention investigated JNJ-78436735 maturation median mRNA vaccine mRNA-1273 Myeloma of BNT162b2 Patient patient population plasma Population proportion receiving Region response spike-specific T-cell Spike-specific T-cell responses Surface glycoprotein T-cell T-cell receptor T-cell Response TCR tested therapy underlying disease vaccination Vaccines [DOI] 10.1111/bjh.18434 PMC 바로가기
Potential of antibody pair targeting conserved antigenic sites in diagnosis of SARS-CoV-2 variants infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of virological methods [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody pair Antigen antigenic site antigenic sites binding domain candidate caused clinical samples Clusters complex conformational conserved Coronavirus disease 2019 COVID-19 COVID-19 pandemic demonstrated determine develop diagnosis of SARS-CoV-2 diagnostic early diagnosis ELISA Infection mAb mAbs monoclonal antibody pandemic Potential pseudovirus RBD RBD-specific mAbs recognizing residue SARS-CoV SARS-CoV S protein SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 S protein SARS-CoV-2 variant selected Sensitivity and specificity spike Spike antigen Spike protein substitutions Treatment variant VOCs [DOI] 10.1016/j.jviromet.2022.114597 PMC 바로가기
Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workersArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 진단, [키워드] age alcohol all age groups anti-RBD antibody antibody level antibody levels Antibody Response Antibody titer Asian baseline binding domain BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Boosted vaccination booster dose booster vaccination conducted COVID-19 COVID-19 vaccine dose eight elevated Ethnic groups group healthcare worker Healthcare workers healthy IgG information investigated Japan Japanese median median titer of BNT162b2 participant Prevent provided RBD response SARS-CoV-2 vaccine second dose serum shown significant increase the vaccine university vaccination Welfare [DOI] 10.1016/j.jiac.2022.07.006 PMC 바로가기
SARS-COV-2 antibody responses to AZD1222 vaccination in West AfricaArticle Published on 2022-10-172022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, [키워드] African Analysis antibodies antibody Antibody Response AZD1222 baseline binding antibody binding domain booster Breakthrough infection Cohort Combination Community Evidence healthcare worker highlighting IgG Immunity immunogenic incidence independent indicate Infection marker neutralisation assay neutralising antibody response neutralizing antibody titre participant Population populations post vaccination pre-vaccination protective neutralizing antibody Pseudotyped virus RBD SARS-CoV-2 seroprevalence second dose significantly increased titre vaccination West [DOI] 10.1038/s41467-022-33792-x PMC 바로가기
Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of ConcernArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ability ACE2 binding antibody Antibody titer Antigen binding domain binding epitope characterized concern coronavirus 2 coronavirus disease COVID-19 COVID-19 neutralizing antibody Delta domains effective high affinity high stability highlight Infection introduced lung cell Neutralizing neutralizing antibody New omicron pathogen plasma Protein RBD respiratory SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants single-domain antibody Spike protein suggested therapeutic option unique variable variant VNAR therapy was tested was used [DOI] 10.3390/ijms232012267 PMC 바로가기
Safety and immunogenicity of intradermal administration of fractional dose CoronaVac®, ChAdOx1 nCoV-19 and BNT162b2 as primary series vaccinationArticle Published on 2022-10-042022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] administration Adverse adverse effect anti-RBD Anti-RBD IgG antibody Antibody Response Arm ARMS binding domain BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 comparable Concentration conducted CoronaVac country COVID COVID vaccine COVID-19 COVID-19 vaccine COVID-19 vaccines dose Effect Effects eligible exploratory first dose fractional dose vaccination Frame Heterologous heterologous regimen highest homologous IgG immunogenic implication IMPROVE Intradermal intradermal vaccination intradermal vaccine intramuscular intramuscular vaccination less lowest of BNT162b2 Omicron variant pilot study Population Protein regimen regimens reported Safe Safety SARS-CoV-2 variants second dose spike Standard dose Study participants systemic adverse reaction T-cell Response the SARS-CoV-2 undetectable vaccination Vaccine vaccine immunogenicity vaccine safety [DOI] 10.3389/fimmu.2022.1010835 PMC 바로가기
Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticalsArticle Published on 2022-10-012022-11-15 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened [DOI] 10.1111/jfbc.14262 PMC 바로가기