The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6Article Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] antibodies antibody Antibody escape mutation binding binding interaction claimed COVID-19 human population IMPROVE molecular Mutation mutations N501Y Neutralizing antibodies neutralizing antibody pathogen Potential treatment predicted previous study Receptor binding domain responsible resulting S-RBD SARS-CoV-2 severity of COVID-19 the SARS-CoV-2 therapeutic [DOI] 10.1038/s41598-022-23482-5 PMC 바로가기
Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interactionArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting-enzyme-2 binding binding interaction blocking virus entry Brown caused characterized coronavirus demonstrated disease ELISA enzyme-linked immunosorbent evaluate evaluated feasible global pandemic immunization immunized Immunoglobulin immunoglobulin Y in vitro Infection inhibit kDa Laying Laying hens molecular weight Neutralizing nucleocapsid purified RBD RBD-ACE2 Receptor binding domain Receptor-binding-domain SARS-CoV-2 SARS-CoV-2. SDS-PAGE serum Specific spike glycoprotein [DOI] 10.1016/j.intimp.2022.109280 PMC 바로가기
A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptideArticle Published on 2022-10-262022-11-15 Journal: Scientific Data [Category] COVID19(2023년), SARS, 진단, [키워드] antibody antibody sequences Antigen binding binding interaction binding score can be used CDRs collected creating dataset evaluate in silico include knowledge machine learning models Mutation naïve peptide predicted provide Quantitative quantitative measurement random Region resulting SARS-CoV-2 sequence starting [DOI] 10.1038/s41597-022-01779-4 PMC 바로가기
Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticalsArticle Published on 2022-10-012022-11-15 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex Complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened [DOI] 10.1111/jfbc.14262 PMC 바로가기
Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike proteinArticle Published on 2022-10-012022-11-16 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Amino acid antigenic binding binding interaction change characteristic coronavirus COVID-19 domain entry inhibitors Genetic highlight human Angiotensin-converting enzyme information inhibitor mutated Mutation Mutation informatics physicochemical Protein provide RBD reported resulting SARS-CoV-2 SARS-CoV-2 variants spike spike protein. strain targets the RBD the SARS-CoV-2 the spike protein Variability viral pathogenicity [DOI] 10.1016/j.drudis.2022.06.012 PMC 바로가기
Identification of the binding interactions of some novel antiviral compounds against Nsp1 protein from SARS-CoV-2 (COVID-19) through high throughput screening고처리량 스크리닝을 통한 SARS-CoV-2(COVID-19)의 Nsp1 단백질에 대한 일부 신규 항바이러스 화합물의 결합 상호작용 확인Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 40S Analysis Antiviral compound bind binding affinity binding interaction Cell ChEMBL complexes COVID-19 docking drug designing drug library effective Factors human host identification in-silico Ligand ligands molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations nsp1 predict Protein Proteins responsible ribosomal subunit RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 SARS-CoV-2 pandemic screened Spike protein spreading tested the spike protein Treatment Virtual screening virulence virulence factor virulence factors. virus [DOI] 10.1080/07391102.2021.1887763 PMC 바로가기 [Article Type] Article
Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineagesArticle Published on 2022-09-012022-11-16 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated African amino acid substitution analysis AY.1 B.1.617.2 B.1.621 binding binding interaction China Combination Complexes COVID-19 Delta docking domain Effect exhibited Factors Genetic hACE2 hACE2. Host human Angiotensin-converting enzyme Interaction investigated Latin Lineage missense variant Missense variants MM/GBSA molecular docking molecular docking analysis molecular dynamics Molecular dynamics simulation MOST Mutation mutations non-Finnish European omicron Population populations predict prevalent protein stability rate of infection RBD Receptor binding risk SARS-CoV-2 SARS-CoV-2 RBD South Asian spike glycoprotein suffered the SARS-CoV-2 Transmissibility variant variants variants of concern viral variant virus was performed Wuhan [DOI] 10.1016/j.compbiomed.2022.105903 PMC 바로가기
In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 InternalizationAlchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구Article Published on 2022-08-142022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein spike glycoprotein. tested V483A virus virus infection Virus spike wild strain [DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article
Measurements of SARS-CoV-2 antibody dissociation rate constant by chaotrope-free biolayer interferometry in serum of COVID-19 convalescent patients코로나19 회복기 환자의 혈청 내 무카오트로프 생물층 간섭계를 통한 SARS-CoV-2 항체 해리율 상수 측정Article Published on 2022-08-012022-09-12 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, [키워드] Antibody concentrations avidity binding binding interaction binding kinetics Biolayer interferometry BLI children Clinical use clinical utility coated with convalescent COVID-19 patients COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient Critical demonstrated dissociation dissociation rate Dissociation rate constant Efficiency functional intensity Kinetics knowledge Lower measurement non-specific pediatric probe RBD Real-time monitoring Receptor binding domain reduction reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike protein SARS-CoV-2. sera serum serum albumin serum antibody Vaccines were measured [DOI] 10.1016/j.bios.2022.114237 PMC 바로가기 [Article Type] Article
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructuresSARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus virus strain viruses while wild type [DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article