Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineagesArticle Published on 2023-03-152024-09-05 Journal: iScience [Category] update2024, [키워드] biochemical analysis Components of the immune system Virology [DOI] 10.1016/j.isci.2023.106413 PMC 바로가기 [Article Type] Article
New-onset dermatomyositis following COVID-19: A case reportArticle Published on 2022-10-242022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome addition anti-aminoacyl tRNA synthetase (ARS) antibodies anti-synthetase antibodies antibodies antibody association autoantibody Autoimmune Autoimmune disease Autoimmune diseases biochemical analysis Biological Case report caused Chest clinical feature Clinical features complications Computed tomography contributed coronavirus Coronavirus disease 2019 Corticosteroids cough COVID-19 de novo dermatomyositis dermatomyositis. develop diagnosed diagnostic Dyspnea edema elevations enzyme-linked immunosorbent exacerbate Fever highlight Hospitalization IgG ILD immunoblot infected individual Infectious disease Inflammatory interstitial Interstitial lung disease Japan Japanese lower lobe Lungs male manifestation MOST myalgia myopathies myositis Occurrence organ pathological findings Patient polymerase chain positive Prednisolone presenting profile respiratory symptom SARS-CoV-2 skin rash sore throat Swab syndrome tested transaminases treated tRNA weakness [DOI] 10.3389/fimmu.2022.1002329 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Smart Diagnostics: Combining Artificial Intelligence and In Vitro DiagnosticsArticle Published on 2022-08-242022-11-15 Journal: Sensors (Basel, Switzerland) [Category] 진단, [키워드] artificial artificial intelligence biochemical analysis Biomarker bladder Cancer cancers cardiovascular diseases Care cartridge clinical decision clinical decision support tool clinical study clinically COVID-19 cross-reactive cytology diagnostic diagnostics disease disease detection disease severity Effect essential element Health healthcare identify Image analysis immunoassay IMPROVE in vitro in vitro diagnostics intelligence lab lab on a chip lung management multiplex oncology outcome Patient care Perspective platform point of care reported score SmaRT Support the patient trajectory Universal utility [DOI] 10.3390/s22176355 PMC 바로가기
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanismsSARS-CoV-2 RNA 의존성 RNA 중합효소의 돌연변이는 별개의 메커니즘으로 렘데시비르에 대한 내성을 부여합니다Article Published on 2022-08-032022-09-11 Journal: Science Translational Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral betacoronaviruses biochemical analysis biochemical pathway clinical settings Concentration consensus sequence consensus sequences coronavirus Critical defined demonstrated drug Drug administration Factor food Genetic greater GS-441524 half-maximal effective concentration Hepatitis homologous Increases increases in infections Lineage mechanism motif murine hepatitis virus Mutation nonstructural protein 12 nonsynonymous mutation Nonsynonymous mutations Nsp12 nucleoside overcome parent nucleoside passages phenotypic Prevent promote RdRP RDV Remdesivir Replication RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp Sequence analysis Ser severe acute respiratory syndrome Coronavirus Substitution substitutions substrate the SARS-CoV-2 to define Treatment triphosphate uridine triphosphate viral lineage [DOI] 10.1126/scitranslmed.abo0718 PMC 바로가기 [Article Type] Article
Angiotensin II infusion in COVID-19: An international, multicenter, registry-based studyMulticenter Study Published on 2022-05-012023-07-07 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] biochemical analysis coronavirus respiratory tract SARS Coronavirus [DOI] 10.1002/jmv.27592 PMC 바로가기 [Article Type] Multicenter Study
Cardiac Fibrosis Is a Risk Factor for Severe COVID-19심장 섬유증은 심각한 COVID-19의 위험 요소입니다Immunology Published on 2021-10-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis biochemical analysis Blood cardiac cellular Clinical deterioration Clinical outcome Cohort Contact controls coronavirus coronavirus disease Coronavirus disease 2019 correlated strongly COVID-19 COVID-19 patients Deceased disease severity echocardiographic echocardiography elevated emergency department explain Factor fibrosis growth factor heart Increased Infection left lung Lungs marker matched controls mRNA mRNA level mRNA levels Myocardium NRP-1 Patient patients hospitalized performed predicted Prevalence pulmonary fibrosis quantification reported respiratory risk risk factor RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid severe disease progression sIL1 TGF-β1 TGF-β1 transforming growth factor ventricular Viral viral entry with COVID-19 [DOI] 10.3389/fimmu.2021.740260 PMC 바로가기 [Article Type] Immunology
Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality그룹 IIA 분비 포스포리파제 A2는 COVID-19 사망률로 이어지는 병리생물학과 관련이 있습니다Clinical Trial Published on 2021-10-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] Analysis biochemical analyses biochemical analysis Blood urea nitrogen catalytically active cellular and molecular Cellular and molecular mechanisms Cellular immune response central node circulating clinically Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality COVID-19 patient death Deceased Decision tree died disease severity elevated fatal COVID-19 group hypoxia identify immune independent Inflammation inhibitor kidney dysfunction machine learning mechanism median value metabolite Mild Mild disease mitochondrial mitochondrial dysfunction Molecular pathology multiple organ dysfunction nitrogen organ dysfunction pathology Patient performed Phospholipase A2 plasma plasma sample plasma samples Random forest reduce regression analysis responsible secreted severe COVID-19 significantly Stratification survivor tested the median therapeutic target urea variable with mild disease [DOI] 10.1172/JCI149236 PMC 바로가기 [Article Type] Clinical Trial
No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did notResearch Article Published on 2021-08-162022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age average benefit biochemical analysis Biomarker C-reactive protein Chloroquine Chloroquine phosphate clinical trial comparable Control control group controls country COVID-19 creatinine demographics Effectiveness electrocardiogram Electrocardiograms elevated Evidence FIVE group heart failure Heart injury increased risk Laboratory lack median MOST NT-proBNP pandemic Patient patients with COVID-19 promoted receiving Result risk severe adverse events Severity of disease statistically significant difference the study group therapeutic Thrombocytes treat treated Treatment [DOI] 10.1371/journal.pone.0256035 PMC 바로가기 [Article Type] Research Article
Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedsideReview Published on 2021-05-282023-07-01 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, [키워드] biochemical analysis Coronaviridae drug targets Multi-target pharmacology pathophysiology therapeutic design [DOI] 10.1016/j.meegid.2021.104944 PMC 바로가기 [Article Type] Review