Cont-ID: detection of sample cross-contamination in viral metagenomic dataarticle Published on 2023-10-132024-09-05 Journal: BMC Biology [Category] update2024, [키워드] Bioinformatic Contamination detection metagenomic Sequencing virus [DOI] 10.1186/s12915-023-01708-w PMC 바로가기 [Article Type] article
Single-cell RNA sequencing and multiple bioinformatics methods to identify the immunity and ferroptosis-related biomarkers of SARS-CoV-2 infections to ischemic strokearticle Published on 2023-08-302024-09-05 Journal: Aging (Albany NY) [Category] update2024, [키워드] Bioinformatic Ferroptosis Ischemic Stroke SARS-CoV-2 Single-cell RNA sequencing [DOI] 10.18632/aging.204966 PMC 바로가기 [Article Type] article
Bioinformatic analysis of the S protein of human respiratory coronavirusArticle Published on 2023-01-162024-09-05 Journal: Molecular phylogenetics and evolution [Category] update2024, [키워드] Bioinformatic Human respiratory coronavirus S protein [DOI] 10.1016/j.ympev.2023.107704 PMC 바로가기 [Article Type] Article
[ORGANIZATION OF GENOMIC SURVEILLANCE FOR SARS-CoV-2 WITHIN THE MOSCOW CITY HEALTH DEPARTMENT]Article Published on 2022-12-152023-07-10 Journal: Problemy sot︠s︡ialʹnoĭ gigieny, zdravookhranenii︠a︡ i istorii medit︠s︡iny [Category] COVID19(2023년), [키워드] Bioinformatic COVID-19 Next-generation sequencing SARS-CoV-2 [DOI] 10.32687/0869-866X-2022-30-s1-1061-1066
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic CardiomyopathyArticle Published on 2022-09-272022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Analysis Bioinformatic Biology Biomarker Cardiomyopathy cardiovascular system Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 progression datasets DEGs differentially expressed gene disorder drug drug candidates Effect functional Gene Expression Omnibus Genes Genetic GSE147507 identify individual knowledge Lungs microRNA mortality rate; ontology terms other organs patients with COVID-19 protein-protein interaction Proteins Research RNA SARS-CoV-2 Sequencing shared pathway shown statistical Support System therapy transcription factors transcriptomic while [DOI] 10.1155/2022/5337380 PMC 바로가기
3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signalingArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] 293T 293T cell 3’UTR acute respiratory syndrome Alter Apoptosis Bioinformatic Cell cell proliferation cellular processes checked coronavirus COVID-19 cytokine cytokine signaling demonstrated down-regulation drugs growth Host host miRNA human miRNAs IL6 induce inhibit Interaction introduced mechanism miRNA miRNAs motif noncoding RNA overexpressed predicted public health threat reduce reducing regulate Regulation reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA SARS-CoV-2 S SARS-CoV-2 spike screened spike gene target TNF-α UTR Vaccine virus RNA was determined [DOI] 10.3389/fimmu.2022.924667 PMC 바로가기
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestriesOAS1 넌센스 매개 부패의 유전적 조절은 유럽 및 아프리카 혈통의 환자에서 COVID-19 입원과의 연관성을 뒷받침합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African allele Analysis Antiviral association Bioinformatic clearance clinical trial contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity decrease disease early treatment European exonic expression functional Genetic genetic regulation Haplotype Hospitalization Hospitalized in vitro study interferon interferons locus mitigate molecular mechanism molecular mechanisms OAS1 Patient Protein reduced Regulation risk SARS-CoV-2 SARS-CoV-2 clearance severe COVID-19 splicing susceptibility variant with COVID-19 [DOI] 10.1038/s41588-022-01113-z PMC 바로가기 [Article Type] Article
Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening Research Published on 2022-06-212022-10-05 Journal: Cell Death & Disease [Category] 변종, [키워드] affected airway Analysis Arm Bioinformatic can be used cause caused ciliary clinical feature co-immunoprecipitation demonstrated DNAH9 drug Drug screening etiology expression feature functional genetic disease identify Immune cell infiltration infections lack lung failure Lung function mice mimicking mutant Mutation outcome Pathogenesis Patient patients performed Phenotypes platform Protein protein levels randomization Respiratory tract infections responsible shown the patient Therapies western blot Western blot analysis [DOI] 10.1038/s41419-022-05010-5 [Article Type] Research
Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6/STAT3임상 데이터 마이닝은 IL-6/STAT3에 대한 이중 결합에 의해 중간 정도의 CovID-19에 대한 잠재적 인 허브 쌍으로 간카오-밴 내증을 밝혀냅니다.Article Published on 2022-06-012022-08-31 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료제, [키워드] activator Analysis applied association benzyl binding Bioinformatic Chinese Chinese medicines (CMs) clinical clinical records Commission coniferin coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokine storm Data mining Defense demonstrated dual FIVE Frequency Gancao-Banxia Gene ontology genomes group highest IL-6 immune response immune responses indicated Inflammatory response ingredient inhibit interleukin interleukin-6 Interleukin-6 (IL-6) KEGG Kyoto licochalcone a Medicine Moderate COVID-19 moderate COVID-19 patients molecular docking multisite network network pharmacology Pathways patients piperazine potential mechanisms PPI protein-protein interaction provided quercetin quinone Radix reveal SARS-CoV-2 signal Signal transducer and activator of transcription Signal transducer and activator of transcription 3 (STAT3). signaling pathways STAT3 Support target targets the cytokine storm therapeutic efficacy therapy Transcription Viral were used [DOI] 10.1016/j.compbiomed.2022.105457 PMC 바로가기 [Article Type] Article