Galectin-9 in cancer therapy: from immune checkpoint ligand to promising therapeutic targetCell and Developmental Biology Review Published on 2024-01-092024-09-05 Journal: Frontiers in Cell and Developmental Biology [Category] update2024, [키워드] Biological functions Galectin-9 immunotharapy Pan-cancer therapeutic target [DOI] 10.3389/fcell.2023.1332205 PMC 바로가기 [Article Type] Cell and Developmental Biology Review
Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A ReviewReview Published on 2023-12-312024-09-05 Journal: Foods [Category] update2024, [키워드] Biological functions gut microbiome molecular mechanisms sialic acid [DOI] 10.3390/foods13010145 PMC 바로가기 [Article Type] Review
Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronavirusesArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis antiviral drug Biological functions cell entry characterization characterized Coronavirus-2 D614G domains FIVE functional glycosylated help less membrane fusion mutant N-glycosylation O-glycosylation Recombinant spike protein S proteins S1 protein S1 subunit SARS-CoV-2 Sialylation spike Spike protein Spike proteins Vaccine β-coronavirus β-coronavirus. β-CoV β-CoVs [DOI] 10.1016/j.aca.2022.340394 PMC 바로가기
Identifying potential pharmacological targets and mechanisms of vitamin D for hepatocellular carcinoma and COVID-19Article Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, 치료제, [키워드] ACTA1 aggressiveness ALB analyses Analysis analyzed Anti-inflammatory anti-inflammatory action Antiviral effect binding activity bioinformatics Biological functions chemokine Coronavirus disease 2019 COVID-19 cytokine production digestive system Effect effective enrichment analysis epithelial evaluate HCC HCC patient HCC patients help hepatocellular Hepatocellular carcinoma HMOX1 identifying immune response immunomodulatory involved malignancy mechanism molecular molecular docking molecular mechanism network pharmacology pandemic performed pharmacological target poor prognosis Predictive Prognosis prognostic public health RBP4 Regulation risk Seven signaling pathway target gene Target genes therapeutic effect TLR4 TTR Vitamin D with COVID-19 [DOI] 10.3389/fimmu.2022.985781 PMC 바로가기
Sulfide regulation of cardiovascular function in health and disease Reviews Published on 2022-08-052022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] Activation Arrhythmias Atherosclerosis Bioavailability Biological functions cardiovascular disease Cardiovascular function Cardiovascular health cardiovascular system cascades Clinical finding clinical study cystathionine β-synthase disease enzyme Enzymes Health heart failure highlight hydrogen implication Injury Interaction involved metabolites molecular Myocardial infarction nitric oxide Pathologies polymorphism post-translational modification PROTECT reduced Regulation review shown single-nucleotide [DOI] 10.1038/s41569-022-00741-6 [Article Type] Reviews
Natural tannins as anti-SARS-CoV-2 compounds항 SARS-CoV-2 화합물로서의 천연 탄닌Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 Anti-viral anticancer drugs antioxidants biological function Biological functions cellular Compound coronavirus COVID-19 pandemic defined derivative effort family food additives fruits indication knowledge molecular natural outbreak over Pandemics plants SARS-CoV-2 seeds severe acute respiratory syndrome Coronavirus tannin tannins terminology variety wood [DOI] 10.7150/ijbs.74676 PMC 바로가기 [Article Type] Review
IL-17 and IL-17-producing cells in protection versus pathology Reviews Published on 2022-07-052022-10-05 Journal: Nature reviews. Immunology [Category] 치료제, [키워드] anti-inflammatory cytokine antimicrobial peptide approach Autoimmune Autoimmunity Bacteria Biological functions CD4+ CD8+ T cells Cell chronic inflammation cytokine Diseases disorder driving drug target dysregulated effective fungi IL-10 IL-17 IL-17A IL-1β IL-23 immunopathology implicated Infection Inflammation Inflammatory inflammatory pathology innate immune cell monoclonal antibody Neurological diseases neutrophil recruitment pathogen Pathogenesis pathology pathway Population produced promote protective immunity receptor regulate Regulatory T cell response T cells TGFβ therapeutic [DOI] 10.1038/s41577-022-00746-9 [Article Type] Reviews
Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution시그니처 SNP를 기반으로 한 SARS-CoV-2 분기군 특성화, 지속적인 진화 공개Article Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] A97V Amino acid amino acid change amino acid changes biological function Biological functions carried change changes in Characteristics clade clades Cluster COVID-19 cure dataset Deleterious Deleterious mutations evaluate Evolution form Frequency globe identify MAFFT Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP NSP2 nsp4 nucleocapsid Occurrence ORF3a performed phylogenetic analyses Phylogenetic analysis PolyPhen-2 Protein protein structure PROVEAN Q57H RdRP Research responsible SARS-CoV-2 SARS-CoV-2 genome sequence Sequence alignment sequences signature SNP SNPs Spread stability strain T85I unique unique SNP unique SNPs used to evaluate vaccination Vaccine virus virus genome virus strain virus strains Wuhan Wuhan, China [DOI] 10.1016/j.ymeth.2021.09.005 PMC 바로가기 [Article Type] Article
XGBoost-Based Feature Learning Method for Mining COVID-19 Novel Diagnostic MarkersCOVID-19 신규 진단 마커 마이닝을 위한 XGBoost 기반 기능 학습 방법Article Published on 2022-06-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] analyzed biological function Biological functions China Classifier coronavirus coronavirus disease Coronavirus pneumonia COVID-19 database demonstrated diagnostic Diagnostic biomarkers Diagnostic markers downloaded effective enrichment analyses expression profiling Gene Expression Omnibus Genes GEO Health identify involved KEGG learning machine learning marker MCC negative patients novel Novel coronavirus novel coronavirus pneumonia outbreak pathway Pathways Patient patients Pneumonia positive Principal component principal component analysis selected signaling pathway signaling pathways Spread SVM throat swab Viral viral gene expression viral transcription was used Wuhan XGBoost [DOI] 10.3389/fpubh.2022.926069 PMC 바로가기 [Article Type] Article
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review