Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significanceArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Antiviral biological processe China complications death disease Evidence extreme feasible Giving globe immune reaction increase Infection mechanism Molecular biology ncRNA ncRNAs non-coding RNA noncoding RNA Pathogenesis pathogenic virus preventing infection Progress Research resulting RNA SARS-CoV-2 SARS-CoV2 Spread subsequent Symptoms therapeutic therapy virus virus infection [DOI] 10.1016/j.ijbiomac.2022.09.105 PMC 바로가기
Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associationsArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Abstract affecting articles association biological processe Cell comprehensive resource COVID-19 criteria curated database dataset develop diabetes differentially expressed gene dysregulated enriched biological processes environmental factor environmental factors Gene Expression Gene Expression Omnibus Genes Infection initial Interaction lung cancer pathway predict R package retrieved rheumatoid arthritis selected signature smoking statistical analysis statistically tested [DOI] 10.1038/s41598-022-21988-6 PMC 바로가기
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric DisordersArticle Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics. [DOI] 10.3390/v14102270 PMC 바로가기
When the Dust Has Settled: Calculation of Binding Affinities from First Principles for SARS-CoV-2 Variants with Quantitative AccuracyArticle Published on 2022-10-112022-11-16 Journal: Journal of chemical theory and computation [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy ACE2 active against acute respiratory syndrome affinity angiotensin-converting enzyme 2 antibodies antibody applied Beta binding binding free energy biological processe calculation complex coronavirus coronavirus disease Delta delta variant Diversity dust effective estimate host cell Immune escape immune response information methodology molecular omicron Perspective Predictive principle receptor robust SARS-CoV-2 Support the binding affinity the receptor-binding domain Therapies Transmissibility variant variants widespread wild type [DOI] 10.1021/acs.jctc.2c00604 PMC 바로가기
Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failureResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acting acute respiratory syndrome Analysis approach biological process biological processe caused cell differentiation China Chinese components Compound compound screening coronavirus COVID-19 COVID-19 case Critical cytokine signaling Cytoscape Cytoscape software Diagnosis drug-likeness Effectiveness enrichment analysis Evidence heart failure Hemostasis identify IL-17 immune system indicated Infection Inflammatory response injection involved KEGG pathway Kyoto Lung injury mechanism Medicine National Health Commission network network analysis novel coronavirus disease objective overlapped Pathway analysis Pathway enrichment analysis Pathways patients with COVID-19 pharmacological mechanism Pharmacological mechanisms Pharmacology progression protein-protein interaction regulated Respiratory failure Result SARS-CoV-2 Shenfu injection signaling pathway Stage suggested syndrome System target targets TCM Th17 therapeutic therapy Traditional treat treating COVID-19 Treatment was used [DOI] 10.1016/j.compbiomed.2022.105845 [Article Type] Research article
Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, [키워드] Activation addition analyses biological processe Cell cellular chromatin ciliated cell Clinical course COVID-19 disease DNA downregulation Epigenetic epithelial cell expand explain Gene expression profiling gene expression signature healthy control histone methylation Histones Interaction mechanism mechanisms membrane permeability Methylation miRNA misfolded proteins Mitochondria Mitochondrial function molecular nasal nasopharyngeal objective pathogenic mechanism pathway enrichment Patient patients with COVID-19 Regulation Regulatory Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 miRNAs scRNAseq sequence severe COVID-19 Single-cell RNA sequencing Single-cell transcriptomics the patient upregulation were used [DOI] 10.1016/j.compbiomed.2022.105895 [Article Type] Research article
VGsim: Scalable viral genealogy simulator for global pandemicArticle Published on 2022-08-242022-11-16 Journal: PLoS Computational Biology [Category] SARS, 변종, [키워드] Algorithm approach approaches biological processe complex COVID-19 pandemic effort epidemiological event example flexible generate global pandemic help Hierarchical Immunity information knowledge molecular natural selection pandemic Region SARS-CoV-2 genome sequenced Spread Transmissibility variant viral sequence [DOI] 10.1371/journal.pcbi.1010409 PMC 바로가기
Protocol to identify host-viral protein interactions between coagulation-related proteins and their genetic variants with SARS-CoV-2 proteinsArticle Published on 2022-08-032022-11-16 Journal: STAR protocols [Category] SARS, 변종, [키워드] binding site bioinformatics biological processe Complete computer Computer sciences evaluate Genetic variant genetics Health Sciences host protein identify Interaction Molecular biology motif Pathogenesis predict Protein protein complex protein interaction protocol regulated SARS-CoV-2 protein SARS-CoV-2 proteins subpopulations the disease viral invasion Viral protein [DOI] 10.1016/j.xpro.2022.101648 PMC 바로가기
Proteomic Profile of Procoagulant Extracellular Vesicles Reflects Complement System Activation and Platelet Hyperreactivity of Patients with Severe COVID-19응고촉진 세포외 소포의 단백질 프로파일은 중증 COVID-19 환자의 보체 시스템 활성화 및 혈소판 과민반응을 반영합니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute inflammatory response alteration analyzed applied approach biological processe biological processes Biomarker Biomarkers cascades caused change changes in circulating Coagulation complement complement factors computational analysis COVID-19 COVID-19 patients Cytometry degranulation disease pathogenesis Diseases EVs experiment expressed extracellular vesicle Extracellular vesicles Flow flow cytometry group healthy donor healthy donors identify increase in indicated infected with SARS-CoV-2 LC-MS LC-MS/MS molecular pathophysiological Patient plasma Platelet Platelets procoagulant procoagulant activity profile progression Protein proteome proteomic SARS-CoV-2 SEC severe COVID-19 severe COVID-19 patients severity of COVID-19 significant changes in size exclusion chromatography System the disease tissue Tissue Factor total protein Vesicle was performed [DOI] 10.3389/fcimb.2022.926352 PMC 바로가기 [Article Type] Article
Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsCOVID-19 환자의 중증도를 뒷받침하는 혈액 RNA 숙주 반응의 특성화Article Published on 2022-07-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료법, [키워드] abundance addition Administered Alter Analysis asymptomatic infection biological processe biological processes Blood blood transcriptome clinical manifestations COVID-19 patient COVID-19 severity differential expression Differential expression analysis disease dysregulation Genes groups highlight host response immune dysregulation Immunoglobulin immunomodulatory Increasing individual Infection inflammatory immune response life-threatening macrophages Mild moderate neutrophil Neutrophils offer Pairwise comparison pairwise comparisons Pathway enrichment analysis Pathways performed progression Research RNA SARS-CoV-2 severe COVID-19 severe disease severity Transcriptome Treatment unique upregulation Whole blood Whole blood transcriptomics [DOI] 10.1038/s41598-022-15547-2 PMC 바로가기 [Article Type] Article