biology of SARS-CoV-2 – Communicable Diseases Research

Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제,

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

Omicron이 아닌 조상 SARS-CoV-2는 일차 소아 비강 상피 세포에서 덜 효율적으로 복제합니다

Article

Published on 2022-08-012022-09-11
Journal: PLoS Biology [Category] Coronavirus, SARS, 변종,

[키워드] acute respiratory syndrome Adults Air-liquid interface antiviral response Biology biology of SARS-CoV-2 changes in children coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Delta delta variant epithelial cells Evidence Infection infections less Mild symptom nasal epithelial cell nasal epithelium NEC NECs omicron pediatric replicate replicated Replication respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly lower Support susceptible These data vaccination Viral RNA virus VOCs widespread
[DOI] 10.1371/journal.pbio.3001728 PMC 바로가기 [Article Type] Article

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

COVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다

Article

Published on 2022-06-292022-09-11
Journal: mSphere [Category] COVID19(2023년), SARS, 변종,

[키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19
[DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

고유한 서열 식별자를 식별하는 생물정보학 도구인 LeTRS를 사용하여 세포 배양, 동물 모델 및 임상 샘플에서 SARS-CoV-2 알려진 및 신규 서브게놈 mRNA 분석

Article

Published on 2022-05-262022-09-11
Journal: GigaScience [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animal model animal models bioinformatics Biology biology of SARS-CoV-2 can be used Cell Cell culture clinical sample clinical samples complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set diagnostics Direct RNA sequencing Each evaluate generate host response identify implication in some indicated Infection junction longitudinal samples mammalian mechanism medical countermeasure Medical countermeasures Middle East Middle East respiratory syndrome Coronavirus multiphasic Nanopore nasopharyngeal sample nucleic acid open reading frames other coronavirus other coronaviruses Patient plasticity provide Quantitative reflected Regulatory respiratory syndrome coronavirus RNA RNA modification SARS-CoV-2 selection pressure sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgmRNA sgmRNAs subgenomic mRNA subject target targets Transcription transcriptional regulatory sequences transcriptional regulatory sequences. Transmission model unique variant Viral RNA viral RNA synthesis virus was tested
[DOI] 10.1093/gigascience/giac045 PMC 바로가기 [Article Type] Article

Large Scale SARS-CoV-2 Molecular Testing and Genomic Surveillance Reveal Prolonged Infections, Protracted RNA shedding, and Viral Reinfections

대규모 SARS-CoV-2 분자 테스트 및 게놈 감시를 통해 장기간 감염, 장기간 RNA 방출 및 바이러스 재감염이 밝혀졌습니다.

Article

Published on 2022-04-112022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단,

[키워드] acquisition Biology biology of SARS-CoV-2 Cell culture Clinical data collected Coverage cycle Cycle threshold values Deletion deletions diagnostic Epidemics Extended first positive Frame genomic Genomic surveillance highlight identify Immunocompromised patients Immunosuppressed immunosuppressed patients Infection infections Infectious virus initial Johns Hopkin Johns Hopkins Laboratory lack molecular Molecular diagnosis notable Pandemics Patient positive positive result precedent Prolonged Prolonged infection prolonged shedding Reinfection RNA SARS-CoV-2 SARS-CoV-2 genomic surveillance scale sequence Sequencing specimens Substitution Surveillance Testing the median threshold value Time frame vaccination valuable resource variants Viral viral clade viral variant Viral variants viruses were used whole genome Whole genome sequencing
[DOI] 10.3389/fcimb.2022.809407 PMC 바로가기 [Article Type] Article

Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements

인도네시아, 아세안 및 주변 동아시아 국가에서 SARS-CoV-2의 게놈 프로파일링: 기능, 도전 및 성과

Article

Published on 2022-04-082022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] achievement ASEAN Biology biology of SARS-CoV-2 Biotechnology center challenge Clinical research collaboration country COVID-19 COVID-19 pandemic defined delta variant Delta variants East Asian Epidemiology facilitated Frequency Genome genomic Genomic surveillance GISAID highest Indonesia Innovation Interaction Japan Lineage Metadata Mutation N439K Nanopore NICCRAT ONT Open Access outbreak Oxford Phylogenetic analysis predominant Profiling SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 virus Sequencing Singapore spike gene Surveillance team technology training Travel unique university variant variants variants of concern virus virus transmission WGS whole-genome sequencing
[DOI] 10.3390/v14040778 PMC 바로가기 [Article Type] Article

Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene

세포 miR-150-5p는 NSP10 유전자를 조절함으로써 SARS-COV-2 감염의 생물학에서 중요한 역할을 할 수있다.

Research Article

Published on 2021-12-142022-09-10
Journal: RNA Biology [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] analysed Analysis biology of SARS-CoV-2 Biomarker Biomarkers Cell Chain Reaction change circulating circulating biomarkers circulating miRNA circulating miRNAs co-transfection coding strand Combination conducted COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients disease Effect experiment expression followed by healthy controls in vitro Infection infection assays inhibit SARS-CoV-2 inhibited inhibitor mechanism miR-150 miR-150-5p miR-375 miRNA miRNA profile miRNAs moderate-severe modulating NGS nsp10 performed plasma Plasma levels polymerase chain polymerase chain reaction promote provide real-time polymerase chain reaction remains uncertain reversed RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sequencing significant changes in significantly Support T cells transfection western blotting
[DOI] 10.1080/15476286.2021.2010959 PMC 바로가기 [Article Type] Research Article

Pannexin-1 channel opening is critical for COVID-19 pathogenesis

Article

Published on 2021-11-192022-10-30
Journal: iScience [Category] COVID-19,

Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics

백신을 넘어: COVID-19 예상 치료제의 임상 상태

Review

Published on 2021-10-012022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제,

[키워드] accelerate addition Antiviral antivirals approach approaches approval approved drug Biology biology of SARS-CoV-2 candidate Candidates caused clinical Clinical course clinical status Clinical studies clinical study contribute country COVID-19 death demonstrated develop Dexamethasone distribution Efficiency Emergency Health Organization identify Immune escape immunization immunomodulators infected individual infected individuals Infection information interferons lab Long COVID long term Neutralizing antibodies New new infections nucleoside pandemic Patient polymerase problem Prospective protective effect reached Remdesivir reported Research SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 status Symptom the SARS-CoV-2 the vaccine the vaccines therapeutic Therapeutic benefit therapeutic benefits Therapeutic treatment Therapeutics today translation Treatment Treatment strategies treatment strategy vaccination rates Vaccine Viral World Health Organization world population
[DOI] 10.3389/fimmu.2021.752227 PMC 바로가기 [Article Type] Review

Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination

무계대 SARS-CoV-2 게놈의 복제 및 적색 재조합을 사용한 돌연변이 유발

Article

Published on 2021-09-222022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료법,

[키워드] acute respiratory syndrome Antiviral applied approach BAC Bacterial bacterial artificial chromosome Biology biology of SARS-CoV-2 caused Cell culture chromosome click chemistry clone Cloning Combination concerning contribute coronavirus CoV COVID-19 COVID-19 pandemic disease economic devastation facilitate Features FLAG Frame full-length generate Genetic global effort global efforts incoming viral particles labeling Lambda marker morbidity Mortality nucleocapsid Open reading frame pandemic coronavirus platform powerful tool question recombinant virus Recombination Red red recombination replicated Replication reporter reporter virus respiratory reverse genetics SARS-CoV-2 Severe acute respiratory syndrome Severe Acute Respiratory Syndrome CoV single-cell level spatiotemporal Spread Viral viral particle viral replication Viral RNA viral RNA synthesis virus viruses Visualization
[DOI] 10.3390/ijms221910188 PMC 바로가기 [Article Type] Article