Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMOArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral drugs atomic binding blind cascade cellular Clustering complex cytotoxicity docking evaluated exhibited flexible FMO inhibitor interact Interaction Ligand M pro mechanism molecular Pathways protease protein-ligand interactions provided residues SARS-CoV-2 SARS-CoV-2 main protease target protein the binding affinity the SARS-CoV-2 [DOI] 10.1038/s41598-022-22703-1 PMC 바로가기
[Building COVID-19’s semiology: The blind wise men and the elephant]Article Published on 2022-09-012022-11-16 Journal: Gaceta sanitaria [Category] COVID19(2023년), SARS, 치료기술, [키워드] airway Atención primaria authors blind build Conocimiento construction Contact tracing cough COVID-19 COVID-19 pandemic Data collection Deaf described description diagnostic disease English fatigue Fever First wave Frame include joint knowledge loss of appetite men Mild Moderate COVID-19 more difficult muscular official Paciente Pain Pandemia participated Patient patients primary care professional professionals protocol Qualitative Shortness of breath Síntomas. Spanish Symptom Symptoms symptoms of COVID-19 the patient was done [DOI] 10.1016/j.gaceta.2021.12.004 PMC 바로가기
Women’s EmotionS, Trauma and EmpowErMent (W-ES.T.EEM) study protocol: a psychoeducational support intervention for victims of domestic violence – a randomised controlled trialArticle Published on 2022-08-252022-10-05 Journal: BMJ Open [Category] 임상, [키워드] Administered adult psychiatry Affect anonymously approach approved articles behavioural blind center change control condition COVID-19 COVID-19 outbreak COVID-19 pandemic Efficacy Ethics ethics committee experimental group face-to-face interventions family Intervention Intimate partner violence Italy manuscript Mental online psychological intervention participant peer-reviewed physical prevented protocol psychoeducational Psychoeducational intervention randomised controlled trial Randomly receiving recruited reported Research Study protocol Support Telemedicine therapy treatment as usual university widespread women written Informed Consent [DOI] 10.1136/bmjopen-2021-060672 PMC 바로가기 [Article Type] Article
Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT새로운 억제제 paxlovid(PF-07321332)와 이버멕틴과 주요 프로테아제 SARS-CoV-2의 단량체와의 상호 작용: 분자 역학, 탄성 네트워크, 고전적 열역학 및 SPT를 기반으로 한 체적 연구Article Published on 2022-08-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] accelerated ANM bind binding binding site blind catalytic catalytic site catalytic sites classical clinical trial clinical trials complex complexes covalent binding COVID-19 COVID-19 pandemic docking drugs electric dipole moment feasible flexible fluctuation fluctuations form GNM homologue inhibitor Interaction intrinsic involved Ivermectin ivermectin B1a M pro molecular molecular dynamics molecular mechanism monomer Paxlovid PF-07321332 protease Protein Region reported scaled SPT structural flexibility Support Viral Volume Volume fluctuation Volume Molar volumetric Voronoi. [DOI] 10.1016/j.compbiolchem.2022.107692 PMC 바로가기 [Article Type] Article
In-silico study for the screening and preparation of ionic liquid-AVDs conjugate to combat COVID-19 surgeResearch article Published on 2022-08-012022-10-05 Journal: The British journal of oral & maxillofacial surger [Category] 변종, 신약개발, 치료제, [키워드] abacavir acyclovir ADME Analysis Antiviral antiviral activity antiviral drug antiviral drugs binding energy blind caused Combination combination therapy complex conjugate Conjugates COVID-19 death DFT Diseases drug effective greater Ionic liquids MD simulation molecular molecular docking MPro pandemic performed protease recorded SARS-CoV-2 screened stability suggested target protein therapeutic Toxicity was done were used [DOI] 10.1016/j.molliq.2022.119277 [Article Type] Research article
Using prosocial behavior to safeguard mental health and foster emotional well-being during the COVID-19 pandemic: A registered report of a randomized trialRandomized Controlled Trial Published on 2022-07-282022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Act Analysis Anxiety assigned benefit blind Canada Compliance condition conditions Control COVID-19 COVID-19 pandemic Depression Effect emotional flexible Follow-up Future Intervention lockdown Measures Mechanical mental health negatively affected Neutral not differ outcome pandemic participant public health randomized trial Randomly recruited reduced Registered replicate the United State Treatment [DOI] 10.1371/journal.pone.0272152 PMC 바로가기 [Article Type] Randomized Controlled Trial
Are micro enemas administered with a squeeze tube and a 5 cm-long nozzle as good or better than micro enemas administered with a 10 cm-long catheter attached to a syringe in people with a recent spinal cord injury? A non-inferiority, crossover randomised controlled trial Research Published on 2022-07-272022-10-05 Journal: Spinal cord [Category] 임상, [키워드] 95% confidence interval Administered assigned blind blinded bowel Care Complete determine hospital non-inferiority non-inferiority margin objective outcome Primary outcome Quality of life randomised controlled trial Randomly reflected reported Result secondary secondary outcome Secondary outcomes sequence setting Spinal cord injury Treatment Treatment effectiveness were measured [DOI] 10.1038/s41393-022-00835-5 [Article Type] Research
Smartphone-Based SARS-CoV-2 and Variants Detection System using Colorimetric DNAzyme Reaction Triggered by Loop-Mediated Isothermal Amplification (LAMP) with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)Article Published on 2022-07-262022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy acute respiratory syndrome affected blind Cas9 clinical samples clinical sensitivity coronavirus COVID-19 COVID-19 patient CRISPR CRISPR-Cas9 D614G detection diagnosed Diagnosis diagnostic disease Diseases eliminated expected False-positive isothermal amplification machine learning Mutation Omicron variant Palindromic palindromic repeat patients Protein raised reaction Repeat S gene SARS-CoV-2 SARS-CoV-2 delta sensitivity Smartphone specificity System T478K the SARS-CoV-2 triggered variant variants [DOI] 10.1021/acsnano.2c04840 PMC 바로가기
Virtual repurposing of ursodeoxycholate and chenodeoxycholate as lead candidates against SARS-Cov2-Envelope protein: A molecular dynamics investigationSARS-Cov2-Envelope 단백질에 대한 주요 후보로 우르소데옥시콜레이트 및 케노데옥시콜레이트의 가상 용도 변경: 분자 역학 조사Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] absence affected Analysis binding blind candidate caused CDC channel Chenodeoxycholate Comparative complexes computational method Contact COVID-19 disrupting docking DPPC drug Drug repurposing envelope protein evaluate facilitated followed by functional generate group H-bonding H-bonds homologue homology hydrophobic inhibitor membrane molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular interaction monomeric observation polar profile residue SARS-Cov2-E sequence identity Structural properties structural property survival trajectory transmembrane region ursodeoxycholate ursodeoxycholate. viral cell was used water water molecule water molecules [DOI] 10.1080/07391102.2020.1868339 PMC 바로가기 [Article Type] Article
Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in CanadaSARS-CoV-2의 뉴클레오캡시드 유전자 돌연변이의 출현은 캐나다에서 PCR 검출을 방해합니다Article Published on 2022-06-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] Accuracy acute respiratory syndrome coronavirus Analysis assays blind Canada Cepheid contributed coronavirus detect diagnostic Diagnostic accuracy effort emergence escape mutant Genetic interfere limit maintain moderate molecular molecular test Molecular tests Mutation mutational rate mutations N gene nucleocapsid Nucleocapsid gene PCR Phylogenetic analysis platform positive Prevalence PROTECT Region regions required respiratory robust SARS-CoV-2 SARS-CoV-2 sequence sequence Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus variants of interest virus while [DOI] 10.1038/s41598-022-13995-4 PMC 바로가기 [Article Type] Article