Exploring blood transcriptomic signatures in patients with herpes zoster and postherpetic neuralgiaarticle Published on 2024-08-152024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] blood transcriptome differential expression gene herpes zoster Patient Postherpetic neuralgia RNA-Seq [DOI] 10.3389/fcimb.2024.1425393 PMC 바로가기 [Article Type] article
Whole Blood–based Transcriptional Risk Score for Nonobese Type 2 Diabetes Predicts Dynamic Changes in Glucose MetabolismClinical Research Article Published on 2024-01-092024-09-05 Journal: The Journal of Clinical Endocrinology & Metabolism [Category] update2024, [키워드] blood transcriptome glucose metabolic traits risk prediction transcriptional risk score type 2 diabetes [DOI] 10.1210/clinem/dgad466 PMC 바로가기 [Article Type] Clinical Research Article
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsCOVID-19 환자의 중증도를 뒷받침하는 혈액 RNA 숙주 반응의 특성화Article Published on 2022-07-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료법, [키워드] abundance addition Administered Alter Analysis asymptomatic infection biological processe biological processes Blood blood transcriptome clinical manifestations COVID-19 patient COVID-19 severity differential expression Differential expression analysis disease dysregulation Genes groups highlight host response immune dysregulation Immunoglobulin immunomodulatory Increasing individual Infection inflammatory immune response life-threatening macrophages Mild moderate neutrophil Neutrophils offer Pairwise comparison pairwise comparisons Pathway enrichment analysis Pathways performed progression Research RNA SARS-CoV-2 severe COVID-19 severe disease severity Transcriptome Treatment unique upregulation Whole blood Whole blood transcriptomics [DOI] 10.1038/s41598-022-15547-2 PMC 바로가기 [Article Type] Article
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome무증상 코비드 -19 감염에서 상향 조절 된 유형 I 인터페론 반응은 개선 된 임상 결과와 관련이 있습니다.Article Published on 2021-11-252022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 치료법, 치료제, [키워드] Antigen presentation approach Asymptomatic Asymptomatic cases Asymptomatic COVID-19 Biomarker Biomarkers blood transcriptome CD177 Clinical outcome Computational biology and bioinformatics COVID-19 COVID-19 case COVID-19 disease disease Disease progression downregulated downregulation dysregulation early response early stage effectively controlled help Host humoral ICAM3 IFN IFNAR2 immunology IMPROVE Infection Inflammatory initial interferon interferons IRF2BP1 IRF2BP2 IRF2BPL IRF4 ISG ISGs limit marker MAVS Microbiology Mild mRNA translation neutrophil pathway Pathways progressive disease protective mechanism protective mechanisms response SAMHD1 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity of COVID-19 significantly SOCS3 stimulated suppression symptomatic disease These data TLR8 Transcriptome Treatment type I interferon type I interferons understanding uninfected upregulated upregulation Viral [DOI] 10.1038/s41598-021-02489-4 PMC 바로가기 [Article Type] Article
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children소아에서 다기관 염증 증후군의 유전자 발현 네트워크에서 소진된 세포독성 T 세포의 하향 조절Article Published on 2021-08-112022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Antimicrobial responses Author autoimmune pathogenesis Blood blood transcriptome CD56 CD57 CD8 CD8+ T cell Cell cell activation cell type cell types children co-expression Cohort Control coordinator coronavirus COVID-19 patient Cytotoxic T cell disease disease-associated downregulation Fever Gene Expression Genes independent individual Infection Inflammation Inflammatory Kawasaki disease manifestation Manifestations MIS-C multiple organ multiple organs natural killer nine NK cell NK cells Pathogenesis pathology pathway Pathways Patient patients Peripheral blood probe Probing Prognostic markers replicated respiratory reveal RNA sequencing SARS-CoV-2 severe acute respiratory syndrome Coronavirus syndrome Systems analysis T cell T cells TBX21 Transcriptome transcriptome-wide transcriptomes [DOI] 10.1038/s41467-021-24981-1 PMC 바로가기 [Article Type] Article
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome dataArticle Published on 2021-07-192022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] Analysis blood transcriptome Cohort Data mining development fixed functional immunological Interpretation knowledge molecular patient cohorts physiological state profile profiles Research resources subject supported Systems biology transcriptional transcriptional profiles Transcriptome translational Translational immunology [DOI] 10.1038/s41467-021-24584-w PMC 바로가기 [Article Type] Article
Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine SeroconversionArticle Published on 2021-06-252022-10-31 Journal: Genes [Category] COVID-19, [키워드] 95% CI applied approach AUC B cell B lymphocyte B lymphocytes Biomarker blood transcriptome Cell clinical setting collected correlated COVID-19 COVID-19 vaccines datasets determine develop Direct expressed expression FCRLA Gene Expression gene expression dataset Genes greater immunology Influenza leukocyte log measurement mononuclear cells pathway PBMC peripheral Peripheral blood Precision predict predicted prediction Predictive proportion purified reference gene Responder sensitivity Seroconversion SMD subpopulation subpopulations target gene TNFRSF13C TNFRSF17 transcript transcript abundance Transcriptome Trial TXNDC5 vaccination was used [DOI] 10.3390/genes12070971 PMC 바로가기 [Article Type] Article
Swarm Learning for decentralized and confidential clinical machine learningArticle Published on 2021-05-262022-10-04 Journal: Nature [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] accelerate addition approach blood transcriptome Chest X-ray images chose Classifier clinical study Computational models Control coordinator COVID-19 develop Diagnostic markers disease distribution facilitate feasibility heterogeneous illness learning Local lung machine learning machine-learning other disease outperform Pathologies Patient Precision Predictive medicine Regulation Tuberculosis viral infection [DOI] 10.1038/s41586-021-03583-3 PMC 바로가기 [Article Type] Article
Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across virusesArticle Published on 2021-04-132022-10-30 Journal: Immunity [Category] COVID-19, [키워드] Abstract accelerate age Analysis analyzed Bacterial infections blood transcriptome cells Chikungunya Cohort cohorts conserved conserved host response to viruses COVID-19 defined detrimental diagnostics disease severity Ebola global pandemic Hematopoiesis Host immune response host response host-directed therapy identify Immune cell IMPROVE Increased induce Infection Influenza interferon response Mild multi-cohort analysis outcome outcomes pan-virus analysis Patient profile Protective SARS-CoV-2 severity single-cell Single-cell RNA sequencing systems immunology trajectory transcriptome profile viral infection virus viruses [DOI] 10.1016/j.immuni.2021.03.002 PMC 바로가기 [Article Type] Article