brain tissue – Communicable Diseases Research

An overview of pivotal trials and real-world evidence for CD20-depleting therapy in multiple sclerosis : Immunotherapy with rituximab, ocrelizumab, and ofatumumab

Article

Published on 2022-11-012022-11-15
Journal: Wiener medizinische Wochenschrift (1946) [Category] 바이오마커, 진단,

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초

Article

Published on 2022-08-302022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus
[DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial

Randomized Controlled Trial

Published on 2022-07-122022-10-04
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상,

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research

K18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점

Review

Published on 2022-06-282022-09-11
Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development
[DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review

Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain

Research

Published on 2022-05-262022-10-05
Journal: Communications Medicine [Category] 치료기술,

Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme

다형성 교모세포종에서 코로나바이러스 수용체의 포괄적인 발암성 특징

Article

Published on 2022-04-062022-09-12
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단,

[키워드] ACE2 Analysis ANPEP approaches association bioinformatics Brain brain tissue Cancer caused clinical development Comprehensive coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic Cox regression analysis demonstrated DPP4 ENPEP expression functional GBM health system immune infiltration incidence individuals Kaplan-Meier survival curve molecular monocyte mRNA oncogenic Patient performed poor prognosis positively correlated potential therapeutic target protein level protein-protein interaction receptor receptors SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly increased survival TMPRSS2
[DOI] 10.3389/fimmu.2022.840785 PMC 바로가기 [Article Type] Article

[CRP apheresis in acute myocardial infarction and COVID-19]

[급성 심근경색증과 코로나19에서 CRP 성분채집술]

Review

Published on 2022-04-012022-09-11
Journal: Medizinische Klinik, Intensivmedizin Und Notfallme [Category] MERS, 바이오마커,

[키워드] accompanied Activation Acute myocardial infarction acute phase Biomarker Blood blood plasma brain tissue Cell classical Clinical practice Complement pathway coronavirus disease Coronavirus disease 2019 COVID-19 CRP CRP level CRP levels damaged damaged cells dead cells deleterious effect deleterious effects described disease dramatic increase edema Elimination English hemorrhage Herz humans hypoxia increase in induce Infection Inflammation Inflammation mediators intra-alveolar Ischemia Ischemic labeling leads lung Myocardial infarction occur Part pathogen Pathogens phagocytosis Praxis Protein routine selective sense stroke tissue tissue damage
[DOI] 10.1007/s00063-022-00911-x PMC 바로가기 [Article Type] Review

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

SARS-CoV-2에 감염된 비인간 영장류 뇌의 신경병리학과 바이러스

Article

Published on 2022-04-012022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model animal models Apoptosis Brain brain tissue Central nervous system CNS coronavirus coronavirus disease COVID-19 Critical develop died disease Endothelial cell endothelial cells Evidence evidence of hypoxia Infection Injury ischemic injury manifestation mechanism Neuroinflammation neurological manifestations Neurological symptom Neurological symptoms Neuropathogenesis Neuropathology NHP NHPs non-human primate Patient respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe respiratory disease severity subjects virus
[DOI] 10.1038/s41467-022-29440-z PMC 바로가기 [Article Type] Article

Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis

면역 반응은 차등 유전자 발현 패턴 분석을 기반으로 한 정신 장애를 가진 SARS-CoV-2 감염의 유전 기전의 핵심입니다

Immunology

Published on 2022-02-042022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 approach bioinformatics Bipolar disorder brain tissue clinical manifestation collected comprehensive analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set data sets DEGs depressive depressive disorder differentially expressed gene disorder enrichment analysis enzyme Evidence expressed functional enrichment Gene regulation gene regulation networks Genetic genetic mechanism genetic mechanisms identify immune-related gene immune-related genes incidence individual infected with SARS-CoV-2 infecting Infection infection with SARS-CoV-2 Inflammatory responses Interaction lead leads major depressive disorder MAPK mechanism Mental disorder Mental Disorders mental health disorders Mortality overlapping pathway Patient patients with COVID-19 pattern performed Peripheral blood peripheral blood cell peripheral blood cells Protein–protein interaction Psychiatric psychiatric diagnose psychiatric disorder Psychiatric disorders psychiatric illness receptor reported Research respiratory Respiratory system response SARS-CoV-2 Schizophrenia severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly higher susceptible susceptible cell Systems biology TGF-β Therapies Treatment various tissues were used Whole blood
[DOI] 10.3389/fimmu.2022.798538 PMC 바로가기 [Article Type] Immunology

Identifying New COVID-19 Receptor Neuropilin-1 in Severe Alzheimer’s Disease Patients Group Brain Using Genome-Wide Association Study Approach

Genetics

Published on 2021-10-212022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome age Alzheimer’s disease Alzheimer’s disease Analysis Angiogenesis Blood Brain brain tissue Brain tissues Complication coronavirus correlation COVID-19 data sets degenerative diabetes disease disorders enzyme expressed expression Gene Expression genome-wide association study (GWAS) group identifying in silico analysis neuronal Neuropilin-1 New NRP1 overexpressed Patient patients performed preclinical study predict progression Protein quantification quantitative PCR recent reduce risk factor RNA-Seq RNA-seq analysis RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission severe symptom Support therapeutic drug Total transmembrane protein upregulated western blotting Whole blood
[DOI] 10.3389/fgene.2021.741175 PMC 바로가기 [Article Type] Genetics