Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral AntagonistsArticle Published on 2023-11-302024-09-05 Journal: Viruses [Category] update2024, [키워드] BST2 ORF7a restriction factor SARS-CoV SARS-CoV-2 spike tetherin [DOI] 10.3390/v15122364 PMC 바로가기 [Article Type] Article
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19COVID-19에서 폐 섬유 생성의 시간 의존적 분자 모티프Multicenter Study Published on 2022-01-292022-09-10 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 진단, [키워드] analyzed assigned BST2 Control COVID-19 death duration of hospitalization Evolution expression Fibrogenesis fibrosis healthy controls; Hospitalization IL1R1 increased expression independent independent of Inflammation molecular mechanism mRNA pathway Pathway analysis Pathways Patient PDGFRB performed potential therapeutic target potential therapeutic targets Prevalence pro-inflammatory progressive respiratory failure protein expression pulmonary pulmonary fibrosis Respiratory failure SARS-CoV-2 severe COVID-19 shift significantly study group survivor was increased [DOI] 10.3390/ijms23031583 PMC 바로가기 [Article Type] Multicenter Study
Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis전사 프로파일링 및 기계 학습, COVID-19 진단을 위한 비강 면봉 및 폐 조직 전반에 걸쳐 I형 인터페론 유도성 숙주 반응의 일치하는 생체특징 공개Immunology Published on 2021-11-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] adjusted adopted Analysis approach biosignature BST2 caused complementary computational analysis concordant conserved COVID-19 COVID-19 diagnosis data interpretation dataset Diagnosis Diagnostic method embedding Factor false-negative Genes geometric global pandemic GSE147507 heterogeneous high mortality homological Host host response IFIT1 IFIT2 IFIT3 IFITM1 IFN-I IFN-I signaling infection control Interferome interferon involved ISG15 Limited lung tissue machine learning morbidity MX1 MX2 nasal swab NCBI-GEO network OAS1 OAS2 OAS3 OASL objective other respiratory infections outcome Profiling pulmonary respiratory respiratory infections response Result retrieved RNA-seq data RNA-sequencing RSAD2 RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequencing data severity of COVID-19 similarity Stat1 stochastic stratified transcriptional transcriptional level transcriptomics Type type I interferon virus was used WGCNA [DOI] 10.3389/fimmu.2021.733171 PMC 바로가기 [Article Type] Immunology
Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/TetherinFull Paper Published on 2021-11-172022-10-31 Journal: ChemistryOpen [Category] COVID-19, SARS, [키워드] Absorption Analysis antiviral activity bind BST2 complex complexes Contact destabilize Dynamics Evidence experiments host protein immune response impairing information Interaction Ion Ligand orf7a protein Protein Proteins resulting SARS-CoV-2 SARS‐CoV‐2 SARS‐CoV‐2 virus Sequence analysis Spectroscopy Tetherin/BST2 Viral protein XANES Zn speciation [DOI] 10.1002/open.202100217 PMC 바로가기 [Article Type] Full Paper
Candidate genes of SARS-CoV-2 gender susceptibilityArticle Published on 2021-11-092022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome ADAM10 Affect Analysis applied association bioinformatics BST2 candidate cascade CCR5 complement Computational biology and bioinformatics coronavirus COVID-19 disease Effect effective ENPEP evaluate expressed GATA1 Gender Genetic genetics gonadal host cell human protein immunology Infection initiated Interaction IRF1 IRF2 likelihood men molecular outcome ovarian pandemic Pathways performed reaction receptor signaling response SARS-CoV-2 SARS-CoV-2 treatment SERPING1 severity of symptoms Sex difference susceptibility target the SARS-CoV-2 tissue TLR4 TLR7 TMPRSS2 Topic understanding Variation women [DOI] 10.1038/s41598-021-01131-7 PMC 바로가기 [Article Type] Article
Functional landscape of SARS-CoV-2 cellular restrictionArticle Published on 2021-04-132023-07-01 Journal: Molecular Cell [Category] SARS, [키워드] BST2 Innate immunity interferon ISG ORF7a SARS-CoV-2 viral evasion [DOI] 10.1016/j.molcel.2021.04.008 PMC 바로가기
Deletion of BST2 Cytoplasmic and Transmembrane N-Terminal Domains Results in SARS-CoV, SARS-CoV-2, and Influenza Virus Production Suppression in a Vero Cell LineMolecular Biosciences Published on 2020-12-182022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Antiviral antiviral therapy BST2 Cell cellular China death decrease deleted Deletion domain help Influenza Influenza virus initial Laboratory LINE pandemic Production Protein Proteins Result SARS-CoV SARS-CoV-2 suppression tetherin transmembrane transmembrane domain Vero Vero Cell Wuhan [DOI] 10.3389/fmolb.2020.616798 PMC 바로가기 [Article Type] Molecular Biosciences
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological ComplicationsNeurology Published on 2020-09-252022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome ADAR angiotensin-converting enzyme 2 bioinformatics BST2 caused cells chemokines clinical symptom Complication complications of COVID-19 coronavirus correlation CoV COVID-19 COVID19 CoVs Cytokines death Dipeptidyl peptidase 4 dissemination DPP4 event expression globe IFITM3 Infection influenza A virus IRF3 ISG15 mechanism MERS-CoV Middle East morbidity MX1 MX2 neurodegeneration neuroinvasion neurologic neurological Neurological complication Neurological symptoms NF-κB pathway other molecule pandemic Pathogenesis peripheral nerve system Pneumonia Potential produced Prognosis receptor respiratory syncytial virus RNASEL robust RSAD2 SAMHD1 SAR-CoV2 SARS-CoV-1 SARS-CoV-2 Spread STRING syndrome text mining triggered Type type III interferon with COVID-19 [DOI] 10.3389/fneur.2020.562913 PMC 바로가기 [Article Type] Neurology
Severe acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle releaseResearch Article Published on 2019-07-102022-11-01 Journal: Journal of medical virology [Category] Coronavirus, SARS, [키워드] acute respiratory syndrome alleviate Antiviral association BST2 Cell cellular coronavirus coronavirus spike protein counteract Degradation determine downregulate downregulating downregulation experiment Factor Factors glycoprotein glycosylation human coronavirus 229E Human immunodeficiency virus immune responses Infection inhibit Innate immunity lysosomal ORF7a Particle Particles pathway Pathways proteasomal reduce reduced reported required SARS Coronavirus Spike protein Support target virion virus virus classification virus replication viruses [DOI] 10.1002/jmv.25518 PMC 바로가기 [Article Type] Research Article