A Prospective 1-Year Follow-up of Glycemic Status and C-Peptide Levels of COVID-19 Survivors with Dysglycemia in Acute COVID-19 InfectionMetabolic Risk/Epidemiology Published on 2024-07-112024-09-05 Journal: Diabetes & Metabolism Journal [Category] update2024, [키워드] C-peptide COVID-19 Diabetes Mellitus insulin resistance insulin secretion SARS-CoV-2 [DOI] 10.4093/dmj.2023.0175 PMC 바로가기 [Article Type] Metabolic Risk/Epidemiology
Affordable oral proinsulin bioencapsulated in plant cells regulates blood sugar levels similar to natural insulinArticle Published on 2023-05-162024-09-05 Journal: Biomaterials [Category] update2024, [키워드] C-peptide Cold-chain free Oral delivery Plant Cell Bioencapsulation Proinsulin [DOI] 10.1016/j.biomaterials.2023.122142 PMC 바로가기 [Article Type] Article
A Long-Term Comparison of Presenting Characteristics of Children with Newly Diagnosed Type 1 Diabetes Before and During the COVID-19 PandemicArticle Published on 2022-08-252022-11-15 Journal: Journal of clinical research in pediatric endocrinology [Category] 진단, [키워드] Admission age antibody autoantibody C-peptide Characteristics Child childhood children Clinical characteristics Contact Coverage COVID-19 diabete diabetes Diabetes Mellitus Diabetic diabetic ketoacidosis diagnosed Diagnosis Diseases duration of symptom Frequency group healthcare service hemoglobin Hospital stay Infection investigated Laboratory less morbidity and mortality no difference not differ other disease other diseases pandemic Patient polymerase chain presenting provide raise raised risk severity Sex significantly higher significantly lower significantly shorter Symptom T1D T1D patient the patient Thyroid tissue Transmission two group Type type-1 diabetes. were recorded [DOI] 10.4274/jcrpe.galenos.2022.2021-10-2 PMC 바로가기
Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)—study protocol for a phase 2, randomized, placebo controlled trialarticle Published on 2022-05-232024-09-02 Journal: Trials [Category] 대상포진, [키워드] Autoimmune disease Baricitinib C-peptide insulin Janus kinase (JAK) inhibitor randomized controlled trial (RCT) Type 1 diabetes [DOI] 10.1186/s13063-022-06356-z PMC 바로가기 [Article Type] article
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes새로 진단된 제1형 당뇨병을 가진 소아, 청소년 및 성인을 대상으로 한 임상시험 의약품 평가를 위한 INNODIA 마스터 프로토콜Article Published on 2022-05-182022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adaptive adolescents and adult backbone baseline benefit Beta-cell function Biomarker Biomarkers C-peptide children Clinical data clinical sample clinical samples clinical trials Combination combination therapies comparable control group Decline demonstrated determine diabete diabetes diagnosed dosage Efficacy Efficacy and safety Endpoint evaluate greater identification identify IMPROVE include individual investigational medicinal product lack Master protocol mechanistic data natural history participant phase Phase 2 phase 2 clinical trials phase 2 studies Phase 2 study phase 3 study Prevent prevention product provide response robust sample size calculation Stratification subsequent trials Type 1 diabetes Variation [DOI] 10.1186/s13063-022-06259-z PMC 바로가기 [Article Type] Article
Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactionsArticle Published on 2021-05-142022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] accessory protein accumulating adapter bind binding mechanism biochemically C-peptide C-terminal domain complex Coronavirus replication Critical crystal structure CTD cytosolic demonstrated determine domain electrostatic interaction Evidence Heat shock homodimer hydrophobic Hypothesis immune evasion implicated inhibit Interaction interferon isothermal titration calorimetry ITC mechanism mitochondrial outer membrane motif N-terminal domain NTD Pathogenesis peptide Protein reduced responses SARS-CoV SARS-CoV-2 structural biology the binding affinity unique Virus-host interaction while X-ray crystallography [DOI] 10.1038/s41467-021-23118-8 PMC 바로가기 [Article Type] Article
Prognostic bioindicators in severe COVID-19 patients중증 COVID-19 환자의 예후 생체지표Article Published on 2021-05-012022-08-31 Journal: Cytokine [Category] SARS, 바이오마커, [키워드] Accuracy accuracy and precision acute respiratory syndrome Admission Analysis AUC best Biomarker Biomarkers C-peptide caused characteristic China Combination Concentration coronavirus 2 correlated COVID-19 COVID-19 patient CRP enzyme enzyme immunoassay evaluated hospital IL-6 immuno-inflammatory immunoassay infusion intravenous invasive ventilation KL-6 Logistic regression logistic regression model material mechanical ventilation mediators Mild-to-moderate Novel coronavirus on admission over-expression parameter Patient patients phenotype poor prognosis Precision prognostic receiver operating characteristic respiratory ROC ROC Curve SARS-CoV-2 serum sample serum samples Severe acute respiratory syndrome severe COVID-19 patient severe COVID-19 patients severe group severity significantly higher steroid Steroids to define Treatment two groups Validity variable was performed were measured Wuhan [DOI] 10.1016/j.cyto.2021.155455 PMC 바로가기 [Article Type] Article
Glycemia, Beta-Cell Function and Sensitivity to Insulin in Mildly to Critically Ill Covid-19 PatientsArticle Published on 2021-01-142022-10-30 Journal: Medicina [Category] COVID-19, [키워드] absence Admission Analysis assessment association blood glucose C-peptide calculated Cell Critically ill diabete diabetes estimate function Glucose glycemia glycemic had no hemoglobin Hospitalization humans hyperglycemia ICU ICU patient Ill insulin Insulin sensitivity intensive care Kruskal-Wallis test material measure Model non-critically ill patient Pandemics parameters Patient patients with diabete plasma SARS-COV-2 infection secretion sensitivity severe acute respiratory syndrome coronavirus 2 significantly higher Steady state survivor was done [DOI] 10.3390/medicina57010068 PMC 바로가기 [Article Type] Article
COVID-19-Induced Diabetic Ketoacidosis in an Adult with Latent Autoimmune DiabetesEndocrinology/Diabetes/Metabolism Published on 2021-01-132022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 association autoantibody autoimmune diabete autoimmune diabetes C-peptide caused Complication complications contribute coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 covid-19 and diabetes deficiency diabete Diabetic diagnosed Diagnosis dry cough Evidence fatigue female High dose Hispanic Hospitalization hyperglycemia ICU Immune-mediated insulin intensive care islet islet cell ketoacidosis Latent latent autoimmune diabetes in adults (lada) management mechanism past medical history Patient positive Recognition required SARS-CoV-2 severe complication shown similarity subject tested therapy treatment for COVID-19 type 2 diabete type 2 diabetes worsening [DOI] 10.7759/cureus.12690 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report Research Published on 2020-09-022022-10-05 Journal: Nature metabolism [Category] SARS, 진단, [키워드] absence Admission Affect antibody Antigen autoantibody Autoimmune blood glucose C-peptide carried Case report cells Concentration COVID-19 cytolytic diabete Diabetes Mellitus Diabetic Effect elevated enzyme-linked immunosorbent expressed Genotype glutamic acid Haemoglobin HLA insulin insulin-dependent diabete islet leukocyte male manifestation occurred pancreatic pancreatic β-cell Patient Positive test probable COVID-19 infection receptors risk SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein serum the patient tyrosine phosphatase virus β-cells [DOI] 10.1038/s42255-020-00281-8 [Article Type] Research