SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
In vitro invasiveness and antimicrobial resistance of Salmonella enterica subspecies isolated from wild and captive reptilesArticle Published on 2021-08-312024-09-07 Journal: Zoonoses Public Health [Category] 살모넬라증, [키워드] Caco2 Invasiveness J774.A1 reptile Salmonella PMC 바로가기
Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation전임상 평가를 통해 SARS-CoV-2 및 이의 변이체에 대한 범-CoV 융합 억제제에 대한 구조 및 기능 기반Article Published on 2021-07-292022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 신약개발, 치료제, [키워드] (alpha administration African Alpha animal models antiviral activity antiviral agent Antiviral agents B.1.1.7 Caco2 Calu Calu-3 Cell fusion cell line cell lines cholesterol clinical development COVID-19 pandemic crystal structure D614G E484K Economy effective functional Gamma hACE2 HR1 domain Infection Infectious diseases inhibitor inhibitors intestinal tissues lung Mutation N501Y peptide peptides pseudotyped SARS-CoV-2 public health reduced S protein safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 variant significantly South structural biology target the SARS-CoV-2 transgenic mice Vaccines variant variants Viral viral titer viral titers [DOI] 10.1038/s41392-021-00712-2 PMC 바로가기 [Article Type] Article
Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2Article Published on 2021-04-202022-10-30 Journal: iScience [Category] COVID-19, [키워드] absence Abstract antiviral assay Biology Caco-2 Caco2 Caco2 cells Calu-3 Cell Cell Biology cell line cellular pathways cellular response Characteristics Cytopathic effect dysregulated experimental model growth Huh7 HUH7 cells human cell lines interferon response interferon signaling Laboratory pathogenicity performed Protein proteomics Quantitative Regulation SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible susceptible cell Swedish Variability Variation Virology virus virus production viruses [DOI] 10.1016/j.isci.2021.102420 PMC 바로가기 [Article Type] Article
Aprotinin Inhibits SARS-CoV-2 Replication아프로티닌은 SARS-CoV-2 복제를 억제합니다Article Published on 2020-10-302022-09-11 Journal: Cells [Category] MERS, SARS, 진단, 치료제, [키워드] 2019-nCoV acute respiratory syndrome air–liquid interface Alpha Analysis Anti-SARS-CoV-2 Activity Antiviral approved Aprotinin Caco2 Calu Calu-3 Cell cell type cell types cellular proteases cleavage Concentration concentrations coronavirus coronavirus disease COVID-19 COVID-19 progression cultures disease downregulated downregulation Drug discovery epithelial epithelial cell host cell host cell protease host cell proteases indicated inhibited inhibitor isolates Local local control pandemic Prevent prevention of COVID-19 progression Protease inhibitor protease inhibitors Protein proteomics respiratory SARS-CoV-2 SARS-CoV-2 replication SERPINA1 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome virus systemic disease therapeutic virus virus entry virus replication [DOI] 10.3390/cells9112377 PMC 바로가기 [Article Type] Article