The Possible Impact of Nationwide Vaccination on Outcomes of the COVID-19 Epidemic in North Korea: A Modelling StudyArticle Published on 2022-10-242022-11-16 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis Asymptomatic B.1.1.529 calibrated compartmental model coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 transmission COVID-19 vaccination Democratic People's Republic of Korea dose Epidemic epidemiological epidemiological data Epidemiological models exacerbated Hospitalization Impact incidence indicated lack lifted measure National North Omicron variant outcome parameter Prevalence prevalence of COVID-19 projection proportion proportions public health reduced reported Risk assessment Spread suggested suppress suppressed the disease Transmissibility vaccination Vaccine was used [DOI] 10.3346/jkms.2022.37.e300 PMC 바로가기
Statistical and agent-based modelling of the transmissibility of different SARS-CoV-2 variants in England and impact of different interventions영국의 다양한 SARS-CoV-2 변종의 전파 가능성과 다양한 개입의 영향에 대한 통계 및 에이전트 기반 모델링Article Published on 2022-10-032022-09-11 Journal: Philosophical transactions. Series A, Mathematical [Category] COVID19(2023년), SARS, 변종, [키워드] affected agent Agent-based Modelling Alpha B.1.177 calibrated COVID-19 Delta delta variant driven by England English Epidemics estimate example Infection Intervention multivariate regression modelling. prevented reduced Relaxation SARS-CoV-2 epidemic SARS-CoV-2 variant statistical model Transmissibility vaccination viral variant wild type [DOI] 10.1098/rsta.2021.0315 PMC 바로가기 [Article Type] Article
Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approachArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis applied approach calibrated candidate carried clinical Clinical efficacy clinical trial convalescent CoronaVac COVID-19 COVID-19 pandemic COVID-19 vaccine develop Efficacy humans immunogenicity data Inc. joint literature review LLC Meta-analysis Model-based meta-analysis (MBMA) modelling Modelling and simulation Neutralizing predict predicted Predictive Predictive model Quantitative reported rhesus macaque Safe SARS-CoV-2 SARS-CoV-2 vaccines serum Sharp strain Study design Support systematic literature search the mean titre translation translational USA vaccination Vaccine vaccine candidate Vaccines variant Viral load were used [DOI] 10.1016/j.ebiom.2022.104264 PMC 바로가기
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
Permissive omicron breakthrough infections in individuals with binding or neutralizing antibodies to ancestral SARS-CoV-2Article Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analyzed B.1.1.529 binding binding antibodies binding antibody breakthrough Breakthrough infection calibrated coronavirus correlated include individual Infection longitudinal cohort study marker Neutralizing activity Neutralizing antibodies neutralizing antibody occurred omicron Permissive Population ranged Recombinant spike protein S1 domain SARS-CoV-2 sequence sera Spike protein the spike protein vaccination rates variant WHO World Health Organization Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.08.058 PMC 바로가기
An agent-based model to assess large-scale COVID-19 vaccination campaigns for the Italian territory: The case study of Lombardy region이탈리아 영토에 대한 대규모 COVID-19 예방 접종 캠페인을 평가하기 위한 에이전트 기반 모델: 롬바르디아 지역 사례 연구Article Published on 2022-09-012022-09-11 Journal: Computer methods and programs in biomedicine [Category] 변종, [키워드] administration age agency agent agent-based model analyzed approach assigned available dose available doses build calibrated case study concern Covasim COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cumulative current death deaths Definition dose dynamic early stages Effectiveness Epidemiologic model Free greater group Health Health care Health care worker health care workers help individual individuals Infection infections Italian Italy knowledge lombardy mathematical methodological methodology National nuances parameter priority reduction in Support the vaccine vaccination Vaccine Vaccines variant variants variants of concern [DOI] 10.1016/j.cmpb.2022.107029 PMC 바로가기 [Article Type] Article
Response to COVID-19 during the Tokyo Olympic Games: Did we properly assess the risk?Research article Published on 2022-09-012022-10-05 Journal: Epidemics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age Analysis approach B.1.617 calibrated CIconfidence intervals compartmental model Confidence intervals coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 incidence COVID-19 vaccination COVID-19coronavirus disease 2019 cumulative death delta variant expected game Hospitalization ICUIntensive Care Unit increase in intensive care intensive care unit International IOCthe International Olympic Committee Japan participant PHSMspublic health and social measures physical contact Prevalence projection public health and social measures required response Result SARS-CoV-2severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Severe case Social distancing measure SoEstate of emergency Spread state of emergency subject suggested suppress the epidemic the International Olympic Committee Tokyo Transmissibility [DOI] 10.1016/j.epidem.2022.100618 [Article Type] Research article
High-Throughput COVID-19 Testing of Naso-Oropharyngeal Swabs Using a Sensitive Extraction-Free Sample Preparation MethodArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] SARS, 치료기술, [키워드] approach calibrated Cobas costly COVID-19 detection system diagnosis of SARS-CoV-2 diagnostic Direct direct method downstream extraction-free extraction-free method gold standard High-throughput Infection International lack less log medium naso-oropharyngeal swab nasopharyngeal swab specimen nucleic acid extraction offer ORF1ab outcome PCR PCR assay per day PlexPCR pool positive sample preparation proteinase protocol purification quantification RdRP reagent reagents reduction in required Respiratory Coronavirus reverse transcription-PCR RNA Roche Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA sensitive sensitivity tested Testing time-consuming Transport Treatment Viral load Viral RNA WHO [DOI] 10.1128/spectrum.01358-22 PMC 바로가기
Feasibility of low-cost particle sensor types in long-term indoor air pollution health studies after repeated calibration, 2019–2021 Research Published on 2022-08-262022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] calibrated calibration change cigarette coefficient Degradation Final Health previous study reliability repeated reported Research Thermo Scientific Variability [DOI] 10.1038/s41598-022-18200-0 [Article Type] Research
Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type referenceSARS-CoV-2 변이체의 구조적 생물정보학 분석은 야생형 참조에 비해 Omicron B.1.1.529 스파이크 RBD에 대해 더 높은 hACE2 수용체 결합 친화력을 보여줍니다Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, [키워드] ACE2 binding affinity Alpha Amino acid amino acid substitution amino acid substitutions Analysis B.1.1.529 binding binding affinity Bioinformatics analysis calibrated characterized COVID-19 pandemic develop Effect hACE2 receptor Halo highest hydrophobicity infected with SARS-CoV-2 Interaction linear molecular dynamics Molecular dynamics simulation molecular dynamics simulations much higher new SARS-CoV-2 occurred omicron pandemic RBD Receptor binding domain receptor hACE2 reveal SARS-CoV-2 variant SARS-CoV-2 variants sequence Spread the RBD the SARS-CoV-2 variant variants VoC wild type [DOI] 10.1038/s41598-022-18507-y PMC 바로가기 [Article Type] Article