Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads studyArticle Published on 2022-09-292022-11-16 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] acquisition Analysis ASL assessment automatically Brain brain phenotype Cambridge collected college comparable Complication complications of COVID-19 component correlation COVID dataset defined diagnostic diffusion Effect feasibility File functional General Electric healthy imaging indicated King limitation linear London Measures MRI Neuropsychiatric olfactory over Oxford participant Participants pathogenic mechanisms Patient protocol Quantitative reduced reliability repeated Research SARS-CoV-2 SARS-COV-2 infection sequence Siemen susceptibility UK biobank UKB Variability [DOI] 10.1371/journal.pone.0273704 PMC 바로가기
Associations of Guillain-Barré syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance databaseArticle Published on 2022-09-012022-11-16 Journal: Journal of the peripheral nervous system : JPNS [Category] 변종, [키워드] acute respiratory syndrome Administered Analysis association AstraZeneca Cambridge cause ChAdOx1 nCoV-19 coronavirus coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine database demonstrated Encephalitis Epidemiological study greater Guillain-barrè syndrome Guillain-Barré syndrome variants heterogeneity higher risk Influenza influenza vaccine influenza vaccines information median time Moderna mRNA-based vaccine Occurrence Odds ratio Pfizer reported risk SARS-CoV-2 syndrome the WHO vaccination Vaccines variant World Health Organization [DOI] 10.1111/jns.12507 PMC 바로가기
Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial Research Published on 2022-08-082022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, 치료법, [키워드] 1:1 95% confidence interval antibody assessment baseline blockade Cambridge carrier cognitive Cohort diagnosed disease double-blind Efficacy Endpoint enrolled evaluate Frequency magnetic resonance imaging measure multicenter outcome outcome measure Participants Patient phase 2 trial Placebo placebo-controlled positive Primary outcomes Randomized receive SEMA4D Tapping tomography Treatment treatment-emergent adverse event Trial volumetric [DOI] 10.1038/s41591-022-01919-8 [Article Type] Research
SARS-CoV-2 Infection in Health Care Workers of Trieste (North-Eastern Italy), 1 October 2020-7 February 2022: Occupational Risk and the Impact of the Omicron Variant트리에스테(이탈리아 북동부) 의료 종사자의 SARS-CoV-2 감염, 2020년 10월 1일-2022년 2월 7일: 직업적 위험과 오미크론 변종의 영향Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] biological risk Cambridge Care circulation Contagion Coverage COVID-19 declined doses greater HCW HCWs Health Health care Health care worker health care workers health care-associated infection health protection health protection measures Hospitalization Impact implementation Infection Italy job job task Moderna New York occupational occupational risk omicron Omicron variant Pfizer risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Trieste university USA vaccination vaccine dose Vaccines variant virus were recorded worker Workplace [DOI] 10.3390/v14081663 PMC 바로가기 [Article Type] Article
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID장기간 코로나바이러스에 감염된 혈청 음성 환자의 이전 SARS-CoV-2 감염의 증거Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute illness antibody assay Cambridge Cohort Consensus COVID COVID-19 illness Definition detectable Diagnosis diagnostic Evidence evidence of IFN-γ IL-2 Immunity infected with SARS-CoV-2 Innovation Long Long COVID Medical Research Council MRC NHSBT NIHR non-hospitalised Patient patients peptides positive PCR test Research reveal SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides seronegative patient seronegative patients supported Symptoms T cell T cell response T cell responses T cells tested Trust United Kingdom Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104129 PMC 바로가기 [Article Type] Article
Machine learning for detecting COVID-19 from cough sounds: An ensemble-based MCDM methodResearch article Published on 2022-06-012022-10-05 Journal: Computers in biology and medicine [Category] 바이오마커, 치료기술, [키워드] Accuracy addition Analysis applied AUC calculate Cambridge classification Classifier cough COVID-19 datasets Ensemble Entropy evaluation criteria evaluation metrics feature identify machine machine learning MCDM Non-COVID-19 outperform Precision recursive feature elimination reduction Research sensitivity similarity specificity TOPSIS [DOI] 10.1016/j.compbiomed.2022.105405 [Article Type] Research article
Heterologous immunization with BNT162b2 followed by mRNA-1273 in dialysis patients: seroconversion and presence of neutralizing antibodies투석 환자에서 BNT162b2에 이어 mRNA-1273으로 이종 면역화: 혈청전환 및 중화항체 존재Article Published on 2022-05-252022-09-12 Journal: Nephrology, dialysis, transplantation : official p [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Analysis anti-SARS-CoV-2 antibodies antibody BNT162b2 boost booster Cambridge Characteristics Concentration coronavirus COVID-19 cut-off dialysis disease dose Efficacy Elasomeran Elecsy Genscript Germany heterologous immunization high risk Humoral immunity immunoreactivity Immunosuppression Infection Mainz Moderna Mortality mRNA vaccine mRNA-1273 mRNA-1273 booster neutralization Neutralization assay Neutralizing antibodies neutralizing antibody of BNT162b2 Patient patients performed plaque reduction neutralization PRNT receiver receiving renal replacement therapy ROC Roche Diagnostics SARS-CoV-2 SARS-CoV-2 spike Seroconversion surrogate Test the SARS-CoV-2 titre Tozinameran USA vaccination virus-neutralizing was measured was reduced were measured were used while wild-type SARS-CoV-2 York [DOI] 10.1093/ndt/gfac018 PMC 바로가기 [Article Type] Article
Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial고위험 비-ST 상승 심근경색증에서 초기 침습성 혈관조영술과 표준 치료 비교: 전향적 다기관 무작위 대조 RAPID N-STEMI 시험을 위한 연구 프로토콜Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] 임상, [키워드] all-cause mortality Analysis approved bleeding Cambridge Clinical outcome clinical outcomes completion Coronary coronary angiography Coronary heart disease coronary intervention COVID-19 pandemic defined determine East East of England England enrolled enrolment Ethics ethics committee event event rates expected heart disease heart failure Hospital admission Hypothesis IMPROVE include Infarct invasive Ischaemic heart disease major bleeding mechanistic data multicentre Myocardial Myocardial infarction Neutral Open-label participant Patient patients Percutaneous coronary intervention Pragmatic Primary outcome proportion randomised randomised controlled recommendation registration number registry Research Ethics retrospective secondary outcome Sponsor Standard of care stroke Study protocol submitted Trial trials within 6 months [DOI] 10.1136/bmjopen-2021-055878 PMC 바로가기 [Article Type] Article
Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohortResearch article Published on 2022-04-282022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, [키워드] Academy Accuracy acute illness acute phase age Anxiety association Attention calculated Cambridge characteristic clinical feature Clinical research Cognition cognitive Cognitive assessment cognitive deficit Cognitive function Cohort condition controls COVID-19 Critical care datasets Dementia demographic factor Department Depression determine deviation Effect expected expressed facility finding foundation funding highlighting hospital Hospital admission hospitalised Imperial College London individual less magnitude mechanically ventilated Medical Research Council memory mental health multivariate NHS NIHR Planning Post-traumatic stress disorder predicted preliminary evidence profile Reasoning reduced required Research response scientist severe COVID-19 severity significantly Standard deviation statistical significance supported survivor technology Trust Wellcome Trust with COVID-19 [DOI] 10.1016/j.eclinm.2022.101417 [Article Type] Research article
A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission EventsMethods Published on 2022-03-022022-10-29 Journal: Molecular Biology and Evolution [Category] COVID-19, MERS, SARS, [키워드] Analysis assessment assessments Cambridge clinical settings collected COVID-19 COVID-19 infection Critical epidemic wave Evaluating Evolution First wave foundation genome sequence Genome sequence data highlight hospital identifying individuals Infection knowledge NHS Non-COVID-19 pandemic Potential public health Retrospective analysis SARS-CoV-2 subsequent Transmission Trust university viral infectious diseases [DOI] 10.1093/molbev/msac025 PMC 바로가기 [Article Type] Methods