Efficacy, safety, and pharmacokinetics of capsid assembly modulator linvencorvir plus standard of care in chronic hepatitis B patientsOriginal Article Published on 2024-04-082024-09-05 Journal: Clinical and molecular hepatology [Category] update2024, [키워드] capsid assembly modulator Chronic Hepatitis B Linvencorvir Phase 2 RO7049389 [DOI] 10.3350/cmh.2023.0422 PMC 바로가기 [Article Type] Original Article
Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus InfectionArticle Published on 2023-01-242023-06-12 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, [키워드] capsid assembly modulator Hepatitis B virus [DOI] 10.1128/aac.01348-22 PMC 바로가기
State-of-the-art and emerging antivirals for chronic hepatitis B infectionReview Published on 2022-12-012023-06-13 Journal: Expert opinion on pharmacotherapy [Category] B형 간염, [키워드] Antisense oligonucleotide capsid assembly modulator cccDNA Entry inhibitor functional cure nucleic acid polymer nucleoside nucleotide Small interfering RNA [DOI] 10.1080/14656566.2022.2144219 [Article Type] Review
EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis BArticle Published on 2022-12-012023-06-13 Journal: Antiviral therapy [Category] B형 간염, [키워드] capsid assembly modulator Chronic Hepatitis B core inhibitor core protein allosteric modulator Hepatitis B virus Pharmacodynamics pharmacokinetics Safety [DOI] 10.1177/13596535221127848
Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV InfectionClinical Trial Published on 2021-07-152023-06-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] B형 간염, Fulltext, [키워드] capsid assembly modulator clinical trial hepatitis B treatment Hepatitis B virus response [DOI] 10.1093/cid/ciaa961 PMC 바로가기 [Article Type] Clinical Trial
Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapyClinical Trial Published on 2020-11-012023-06-12 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] antiviral activity capsid assembly modulator Hepatitis B virus phase 1b. [DOI] 10.1111/jvh.13351 [Article Type] Clinical Trial
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379Article Published on 2020-04-212023-06-12 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, [키워드] capsid capsid assembly modulator cccDNA Hepatitis Hepatitis B virus primary human hepatocytes [DOI] 10.1128/AAC.02439-19 PMC 바로가기
Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patientsArticle Published on 2019-06-012023-06-19 Journal: Journal of hepatology [Category] B형 간염, [키워드] antivirals capsid assembly modulator CYEI entecavir HBV nucleotide analogue [DOI] 10.1016/j.jhep.2019.02.006
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B VirusArticle Published on 2018-10-292023-05-23 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, Fulltext, [키워드] capsid assembly modulator CHB Chronic Hepatitis B HBV inhibitors [DOI] 10.1128/AAC.01734-18 PMC 바로가기
Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV InfectionReview Published on 2018-01-012023-06-16 Journal: Current medicinal chemistry [Category] B형 간염, [키워드] antiviraltherapy. capsid assembly capsid assembly modulator core protein Hepatitis B virus misassembly. [DOI] 10.2174/0929867324666170704121800 [Article Type] Review