Effect of Adding the Antimicrobial L-Carnitine to Growing Rabbits’ Drinking Water on Growth Efficiency, Hematological, Biochemical, and Carcass AspectsArticle Published on 2024-08-112024-09-05 Journal: Antibiotics [Category] update2024, [키워드] Alexandria-line rabbits carcass Carnitine hematology lipid profile productive performance [DOI] 10.3390/antibiotics13080757 PMC 바로가기 [Article Type] Article
Besifovir dipivoxil maleate: a novel antiviral agent with low toxicity and high genetic barriers for chronic hepatitis BArticle Published on 2021-12-012023-06-13 Journal: Expert opinion on pharmacotherapy [Category] B형 간염, [키워드] antiviral efficacy besifovir dipivoxil maleate Bone toxicity Carnitine Hepatitis B virus renal toxicity [DOI] 10.1080/14656566.2021.1967321
Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infectionCOVID-19의 위험 계층화 및 질병 중증도 및 사망률 예측: COVID-19 감염에 대한 숙주 반응 측정을 위한 차세대 대사체학Research Article Published on 2021-12-012022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] abnormality Admission alteration association AUC biochemical Carnitine change changes in Characteristics characterized citrulline clinical evaluation Clinical management clinical severity score collected Comorbidities Comorbidity Concentration Confirmed COVID-19 infection COVID-19 COVID-19 infection COVID-19 severity Curve demographics determinant develop disease disease severity enrolled Glutamate healthy volunteers highest Host host response identify immune signature implication individual investigated Kynurenine mass spectrometry measure medical records metabolic factors metabolism metabolite metabolites metabolomics Mild moderate morbidity morbidity and mortality Mortality organic acid ornithine Patient Peripheral blood Peripheral blood sample peripheral blood samples plasma predictor profile Prognosis Prognostic marker Prognostic markers Quantitative receiver risk risk stratification ROC RT-PCR selected severe complication severe complications severity tested Tryptophan urea urea cycle WHO [DOI] 10.1371/journal.pone.0259909 PMC 바로가기 [Article Type] Research Article
Carnitine and COVID-19 Susceptibility and Severity: A Mendelian Randomization StudyNutrition Published on 2021-11-252022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] Analysis association Carnitine causation clinical trials conducted correlation COVID-19 COVID-19 pathogenesis Dexamethasone Egger evaluated facilitate Genetic predisposition Genome-wide association study Hospitalization increase in IVW mendelian randomization Mendelian randomization (MR) molecular functions not significant outcome PROTECT Protective random effect reduce robust Sensitivity analyses severity severity of COVID-19 Significant Single nucleotide polymorphism Standard deviation susceptibility therapeutic target weighted median weighted mode [DOI] 10.3389/fnut.2021.780205 PMC 바로가기 [Article Type] Nutrition
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumoniaReview Published on 2020-12-212022-10-29 Journal: Inflammation research : official journal of the Eu [Category] COVID-19, SARS, [키워드] α-Lipoic acid acute infections anti-inflammatory actions antioxidant applied article Biomarkers Carnitine chronic disorders clinical trials coenzyme Q10 cofactor Combination complementary conditions CoQ10 COVID-19 COVID-19 pandemic demonstrated disorder disorders effective Endpoint Evidence in vitro inflammatory disorder information mitochondrial oxidative stress pathologic Pneumonia Potential proinflammatory Protective provided Result retrieved searched Sepsis therapy Trial [DOI] 10.1007/s00011-020-01423-0 PMC 바로가기 [Article Type] Review
Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm SuppressionArticle Published on 2020-08-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] Δ9-tetrahydrocannabinol Activation acute respiratory distress syndrome addition amino acids Analysis analyzed Apoptosis apoptotic ARDS attenuate BALF Bronchoalveolar lavage fluid Carnitine cause caused Cell Concentration correlated COVID-19 COVID-19 patient cytokine Cytokine storm database disease downregulation elevated enzyme gene expression dataset Human Immune cell increase in induction L-carnitine leading lung Lung inflammation lysine mechanism metabolome metabolomic analysis methionine mice mitochondrial Mortality pathway performed pro-apoptotic receptor respiratory SEB serum signaling pathway similarity Single-cell RNA sequencing staphylococcal enterotoxin B storm suggested suppression survival targets therapeutic Transcriptome transcriptomic analysis treat treated Treatment Trigger was used were used with COVID-19 [DOI] 10.3390/ijms21176244 PMC 바로가기 [Article Type] Article
Pharmacokinetic evaluation of besifovir for the treatment of HBV infectionReview Published on 2018-01-012023-06-19 Journal: Expert opinion on drug metabolism & toxicology [Category] B형 간염, [키워드] adverse effects Besifovir Carnitine Efficacy Hepatitis B virus humans nucleotide analogue pharmacokinetics renal toxicity [DOI] 10.1080/17425255.2018.1417983 [Article Type] Review