Unity among the diverse RNA-guided CRISPR-Cas interference mechanismsJBC Reviews Published on 2024-04-182024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] Cas10 Cas12 Cas13 Cas3 Cas9 cascade CasDinG CRISPR-Cas crRNA RNA binding protein [DOI] 10.1016/j.jbc.2024.107295 PMC 바로가기 [Article Type] JBC Reviews
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome Analysis Beta Beta variant blockade cascade cause CCL2 Characteristics Comparative analysis coronavirus coronavirus 2 COVID-19 COVID-19 pandemic CXCR2 cytokine cytokine release death Disease progression early stage evidenced IL-1β immunological induce Infection Inflammatory cytokine investigated K18-hACE2 late stage Lung pathology mice molecular mechanism Mortality neutrophil recruitment outbreak pathological pathological condition pathology phenotype presymptomatic provide reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variant secreted cytokine Strains the SARS-CoV-2 Transcriptome transcriptomes Transmissibility Treatment variant viral infection weight loss [DOI] 10.1128/spectrum.02371-22 PMC 바로가기
Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMOArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral drugs atomic binding blind cascade cellular Clustering complex cytotoxicity docking evaluated exhibited flexible FMO inhibitor interact Interaction Ligand M pro mechanism molecular Pathways protease protein-ligand interactions provided residues SARS-CoV-2 SARS-CoV-2 main protease target protein the binding affinity the SARS-CoV-2 [DOI] 10.1038/s41598-022-22703-1 PMC 바로가기
Levels of soluble complement regulators predict severity of COVID-19 symptomsArticle Published on 2022-10-182022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] analysed Analysis approach Asymptomatic baseline level Biomarkers cascade circulating Cohort complement Control Course COVID-19 COVID-19 patients Diagnosis disease disease severity driving dysregulation Elevation Evidence Factor Factor H factor H-related proteins FIVE Healthcare systems hospitalisation Hypothesis immune activation individual lack Level majority management mass spectrometry Mild morbidity and mortality outcome outcomes Patient plasma sample predict Protein Proteins quantified responsible SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 virus severe COVID-19 severe disease severity of COVID-19 splice subset Support Symptom variant while with COVID-19 [DOI] 10.3389/fimmu.2022.1032331 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Friend or foe: RIG- I like receptors and diseasesArticle Published on 2022-10-012022-11-15 Journal: Autoimmunity reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation anti-tumor immunity antibody Antiviral antiviral immune response Autoimmune diseases autoinflammatory disease Autoinflammatory diseases Bacterial infections cascade disease Diseases Friend genes encoding Guidance Host IFNs immunomodulatory therapy include involved malaria MDA5 mechanism mechanisms microRNA miRNAs Mutation polymorphism post-translational modification proinflammatory cytokines Proteins recent finding receptor Regulatory RIG-I RLR RLRs RLRs. RNA virus SARS-CoV-2 Signaling single-nucleotide SNPs transcriptional type I interferon [DOI] 10.1016/j.autrev.2022.103161 PMC 바로가기
Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progressionReview Published on 2022-10-012022-10-05 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] Activation addition Anti-inflammatory anticoagulation Antiviral Asymptomatic carrier C1 inhibitor cascade cascades caused Clinical practice complement complement system Complication Contact contact activation system Coronavirus disease 2019 COVID-19 Critically ill patient death disease driver drug Endothelial cell Evidence Inflammatory inhibitor introduced kallikrein-kinin Kallikrein-kinin system monoclonal antibodies multisystemic myocardial injury pandemic potential benefit prevent disease progression randomized study randomized trials SARS-CoV-2 severe COVID-19 syndrome targeting the disease therapeutic option Thromboembolic events Thromboinflammation Treatment Trial [DOI] 10.1016/j.molimm.2022.08.008 [Article Type] Review
Adding colchicine to tocilizumab in hospitalized patients with severe COVID-19 pneumonia: An open-label randomized controlled trialArticle Published on 2022-09-302022-11-15 Journal: Medicine [Category] SARS, 진단, [키워드] 1:1 added Adding Analysis antagonists Anti-inflammatory anti-inflammatory agent approved cascade center Colchicine Corporation cytokine Cytokine storm Efficacy and safety Ethics evaluate hospitalized patient IL-6 IL-6 blockade include Inflammasome inhibiting institutional review board Invasive mechanical ventilation Local mechanism of action Mortality NLRP3 Open-label Patient peer-reviewed Primary outcome Randomized Randomized controlled trial receptor receptor protein reduce Result risk safety profile severe COVID-19 Severe COVID-19 pneumonia Study protocol submitted Tocilizumab upstream [DOI] 10.1097/MD.0000000000030843 PMC 바로가기
Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort studyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] 30-Day mortality Activation Admission Analysis Bacterial Biomarker blood sample C5a cascade clinically suspected comparable complement complement system Concentration Control control group controls COVID-19 COVID-19 patient disease E-selectin elevated endothelial Endothelial cell endothelial cells Endothelium evaluate excluded females galectin-3 galectin-3. ICAM-1 ICU Inflammatory inflammatory condition Inpatient male non-infectious nonspecific occurred outcome Outpatient Patient Pneumonia presenting prospective cohort study recruited respiratory viral infections SARS-CoV-2 SARS-COV-2 infection SC5b-9 significantly significantly higher single-center study VCAM-1 [DOI] 10.3389/fimmu.2022.941742 PMC 바로가기
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기