Generation and characterization of antagonistic anti-human CD39 nanobodiesImmunology Original Research Published on 2024-03-252024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] CD39 ENTPD1 nanobody single-domain antibody VHH [DOI] 10.3389/fimmu.2024.1328306 PMC 바로가기 [Article Type] Immunology Original Research
Elevated CD39+T-Regulatory Cells and Reduced Levels of Adenosine Indicate a Role for Tolerogenic Signals in the Progression from Moderate to Severe COVID-19Article Published on 2023-12-182024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] adenosine ATP CD39 CD73 COVID-19 T-regulatory cells [DOI] 10.3390/ijms242417614 PMC 바로가기 [Article Type] Article
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascadearticle Published on 2023-10-272024-09-05 Journal: BMC Complementary Medicine and Therapies [Category] update2024, [키워드] Apoptosis CD 73 CD39 Combination Immune suppression Target delivery [DOI] 10.1186/s12906-023-04212-4 PMC 바로가기 [Article Type] article
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection바이러스 부하는 급성 중증 SARS-CoV-2 감염에서 미토콘드리아 기능 장애 및 변경된 단핵구 표현형과 관련이 있습니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD16 CD39 Cell cell surface classical monocyte classical monocytes Clinical outcome COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determined by evaluated exhibited expression Frequency GM-CSF healthy control healthy controls high viral load HLA-DR Hospital admission IFN-α Immune checkpoints induce Infection initial innate immune innate immune response less membrane Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function monocyte Monocyte activation Monocytes oxygen pathological mechanism patients PD-1 phenotype reactive oxygen species reactive oxygen specy SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe SARS-CoV-2 severity the cell the median These data Viral viral burden Viral load with COVID-19 [DOI] 10.1016/j.intimp.2022.108697 PMC 바로가기 [Article Type] Article
High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4 + T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19장기간의 COVID-19가 있는 항-CD20 치료를 받은 환자에서 높고 지속되는 생체외 빈도이지만 SARS-CoV-2-특이적 CD4 + T-세포의 변경된 표현형Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] abrogate Altered Analysis anti-CD20 anti-CD20 therapy anti-CD20 therapy. B-cell CD39 CD4 CD4+ CD4+ T-cells CD45 CD45RA CD73 Cell circulating COVID-19 CRP CXCR5 effector cells epitope Ex vivo expression follicular Frequency help helper cell IL-6 Infection inflammation marker Interaction lack LAG-3 membrane protein memory MHC class MHC class II MHC class II Tetramer Patient patients PD-1 phenotype Prolonged receptor reduced robust SARS-CoV-2 skewed T follicular helper cell T-cell T-cell memory T-cell Response T-cells tetramer the patient TIGIT viral replication [DOI] 10.3390/v14061265 PMC 바로가기 [Article Type] Article
Assessment of CD39 expression in regulatory T-cell subsets by disease severity in adult and juvenile COVID-19 casesArticle Published on 2022-05-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] CD39 COVID-19 FOXP3 Infectious diseases Tregs [DOI] 10.1002/jmv.27593 PMC 바로가기
Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and ThromboinflammationCOVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related [DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology
TIM‐3 as a potential exhaustion marker in CD4 + T cells of COVID‐19 patientsCOVID-19 환자의 CD4 + T 세포에서 잠재적인 피로 마커로서의 TIM-3Original Article Published on 2021-09-092022-09-10 Journal: Immunity, Inflammation and Disease [Category] SARS, 치료기술, [키워드] Blood Blood urea nitrogen C‐reactive protein calculated cause CD39 CD4 clinical information clinical symptom Clinical symptoms collected COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 creatinine Critical critical patients deaths disease erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Exhausted cell flow cytometry group groups healthy individuals in healthy individual laboratory data lymphocyte Lymphocytes lymphopenia marker Mild mononuclear cell mononuclear cells neutrophil neutrophil count nitrogen occur overexpression Patient patient groups PBMCs PD‐1 PD‐1 peripheral Peripheral blood Peripheral blood mononuclear cells Result sedimentation rate significant difference significantly higher subjects subpopulation T cell T cells TIM‐3 urea [DOI] 10.1002/iid3.526 PMC 바로가기 [Article Type] Original Article
Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patientsPD1이 아닌 Tim-3 및 CD39의 발현은 중요한 Covid-19 환자에서 CD8 T 세포를 정의합니다Article Published on 2021-04-012022-08-31 Journal: Microbial pathogenesis [Category] MERS, SARS, 바이오마커, 진단, [키워드] (PD-1) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD39 CD8 CD8 T cell CD8 T cells CD8 T-cell Cell cell counts cells combinations coronavirus coronavirus disease COVID-19 Critical dysregulated immune response Exhausted cell expressing expression Frequency group healthy control healthy controls Immunoglobulin individual inhibitory receptor Inhibitory Receptors Lymphocytes marker mononuclear cell mononuclear cells mucin New coronavirus no difference no significant differences Patient patients patients with COVID-19 PBMCs PD-1 PD1 Peripheral blood Peripheral blood mononuclear cells phenotype programmed cell death programmed cell death protein Pronounce Protein recruited Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant difference significant differences significantly lower subject T cells T lymphocyte T lymphocytes T-cell the healthy three group three groups TIM-3 Viral viral infection [DOI] 10.1016/j.micpath.2021.104779 PMC 바로가기 [Article Type] Article
B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19SARS-CoV-2 대 말라리아의 B 세포 분석: 코로나19에서 형질모세포 및 비정형 기억 B 세포의 빈도 증가Clinical Trial Published on 2021-01-012023-07-13 Journal: Journal of leukocyte biology [Category] SARS, 말라리아, [키워드] CD19 CD39 CD73 hyperinflammation [DOI] 10.1002/JLB.5COVA0620-370RR [Article Type] Clinical Trial