A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster ModelArticle Published on 2024-02-152024-09-05 Journal: bioRxiv [Category] update2024, [키워드] CD4+ T cells CD8+ T cells COVID-19 cross-protective pan-coronavirus vaccine SARS-CoV-2 variants of concern [DOI] 10.1101/2024.02.14.580225 PMC 바로가기 [Article Type] Article
CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infectionResearch Article Published on 2023-10-122024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] CD4+ T cells CD70 HIV poor immune reconstitution Th differentiation [DOI] 10.1080/22221751.2023.2271068 PMC 바로가기 [Article Type] Research Article
Cross-Protection Induced by Highly Conserved Human B, CD4 +, and CD8 + T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of ConcernArticle Published on 2023-05-242024-09-05 Journal: bioRxiv [Category] update2024, [키워드] antibodies CD4+ T cells CD8+ T cells COVID-19 Epitopes Immunity immunopathology SARS-CoV-2 SL-CoVs Vaccine variants of concern [DOI] 10.1101/2023.05.24.541850 PMC 바로가기 [Article Type] Article
Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cellsArticle Published on 2023-03-272024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] antibody-secreting cells B cells CD4+ T cells CD8+ T cells COVID-19 vaccines hematology memory T cells SARS-CoV-2 T follicular helper cells tetramer-specific [DOI] 10.1016/j.xcrm.2023.101017 PMC 바로가기 [Article Type] Article
Increased Pro Th1 And Th17 Transcriptional Activity In Patients With Severe COVID-19Research Paper Published on 2023-02-212024-09-05 Journal: International Journal of Medical Sciences [Category] update2024, [키워드] CD4+ T cells COVID-19 severity RORγt Tbet Th1 Th17 [DOI] 10.7150/ijms.80498 PMC 바로가기 [Article Type] Research Paper
mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal DiseasesReview Published on 2022-02-102023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] CD4+ T cells immune response Inflammatory mTOR signaling periodontal disease [DOI] 10.3389/fimmu.2022.827461 PMC 바로가기 [Article Type] Review
The Recombinant E g.P29-Mediated miR-126a-5p Promotes the Differentiation of Mouse Naive CD4 + T Cells via DLK1-Mediated Notch1 Signal PathwayOriginal Research Published on 2022-02-082023-05-31 Journal: Frontiers in Immunology [Category] Fulltext, 조류인플루엔자, [키워드] Cystic Echinococcocosis CD4+ T cells DLK1 miR-126a-5p Notch1 rEg.P29 Th1 Th2 [DOI] 10.3389/fimmu.2022.773276 PMC 바로가기 [Article Type] Original Research
Comprehensive Analysis of CD4 + T Cell Response Cross-Reactive to SARS-CoV-2 Antigens at the Single Allele Level of HLA Class IIHLA 클래스 II의 단일 대립 유전자 수준에서 SARS-CoV-2 항원에 교차 반응하는 CD4 + T 세포 반응의 종합 분석Immunology Published on 2022-01-062022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] aAPC acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleles Antigen antigen-presenting cell Blood can be used CD4 CD4+ T cells circulating class collected Combination common Comprehensive coronavirus cross-reactive cross-reactive T cells defined dominant expressed expressing FIVE healthy donor healthy donors heterozygous highest HLA HLA class II HLA-DP HLA-DQ HLA-DR homology human coronavirus human coronaviruses immunodominance individual individuals Level loci locus magnitude membrane MHC class II alleles nucleocapsid protein Nucleocapsid proteins partial sequence respiratory respond response SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens severe acute respiratory syndrome Coronavirus single allele T cell T cell response T cell responses T cells two allele Two alleles [DOI] 10.3389/fimmu.2021.774491 PMC 바로가기 [Article Type] Immunology
Genome-Wide B-Cell, CD4 + and CD8 + T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Pre-Emptive Pan-Coronavirus VaccinesArticle Published on 2021-11-252023-07-01 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, [키워드] antibodies CD4+ T cells CD8+ T cells COVID-19 Epitopes Immunity immunopathology pan-coronavirus SARS-CoV-2 SL-CoVs Vaccine [DOI] 10.4049/jimmunol.2001438 PMC 바로가기 [Article Type] Article
Longitudinal Follow Up of Immune Responses to SARS-CoV-2 in Health Care Workers in Sweden With Several Different Commercial IgG-Assays, Measurement of Neutralizing Antibodies and CD4 + T-Cell Responses다양한 상업용 IgG 분석, 중화 항체 측정 및 CD4 + T-세포 반응을 사용한 스웨덴 의료 종사자의 SARS-CoV-2에 대한 면역 반응의 종단적 추적Immunology Published on 2021-11-022022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, 치료제, [키워드] Abbot activated Analysis antibodies Architect blood donor Blood donors Care CD4 CD4+ T cells Cell correlation COVID-19 COVID-19 patient COVID-19 patients defined determine DiaSorin domain finding FIVE flow cytometric HCW HCWs Health care Health care worker health care workers iFlash IgG antibodies IgG antibody Immunological response in vitro individuals infected with SARS-CoV-2 Infection Infectious disease Infectious diseases longitudinal measurement membrane Mild moderate NAb NAbs naïve individuals Neutralizing antibodies neutralizing antibody nucleocapsid overlapping pandemic peptide peptide pools performed proportion reactivity recruited response risk S1/S2 SARS-CoV-2 SARS-COV-2 infection sensitivity serological Seropositivity Seroprevalence Sex spike Stimulation Swedish T-cell target Variation were measured worker [DOI] 10.3389/fimmu.2021.750448 PMC 바로가기 [Article Type] Immunology