Transcriptome analysis of PBMCs isolated from piglets treated with a miR-124 sponge construct identified miR124/IQGAP2/Rho GTPase as a target pathway support Salmonella Typhimurium infectionarticle Published on 2023-01-312024-09-01 Journal: Molecular Genetics and Genomics [Category] 살모넬라증, [키워드] Cdc42 IQGAP2 miR-124 Rac1 Salmonella [Article Type] article
Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus InfectionOriginal Research Published on 2021-11-012023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] Avian HEV Cdc42 Hepatitis E virus (HEV) Rho GTPases Virus-host interaction [DOI] 10.3389/fmicb.2021.775083 PMC 바로가기 [Article Type] Original Research
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive PatientsSARS-COV-2- 양성 환자의 비 인두 면봉으로부터의 숙주 세포에서 수입 알파 및 약물 표적 발현 프로파일 링에 대한 Ivermectin 및 Atorvastatin의 효과Article Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] Actin Affect alteration analyzed antihelmintic drug atorvastatin Cdc42 cellular Combination concentrations confocal microscopy COVID-19 COVID-19 patient COVID-19 patients cytoplasmic distribution drug Drug repurposing drug target drugs Effect expression function Gene Expression host cell host cell antiviral response host cells impair Importin in vitro model Infection inhibit involved Ivermectin KPNA3 KPNA5 KPNA7 KPNB1 lipophilic statin Localization mechanism Nasopharyngeal swab nasopharyngeal swabs NF-κB NF-κB activation Non-COVID-19 patients nuclear Nuclear localization Pathogenesis Patient pleiotropic effect poly(I:C) Profiling Result Rho GTPase Rho GTPases RHOA RNA viruses SARS-CoV-2 SARS-COV-2 infection Signaling target transcriptional Transport Treatment triggered Vesicle Viral viral double-stranded RNA [DOI] 10.3390/v13102084 PMC 바로가기 [Article Type] Article
Prediction of repurposed drugs for treating lung injury in COVID-19Research Article Published on 2020-08-262022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Bioinformatics analysis CALR candidate drugs caused Cdc42 Cell cells CGP-60474 chemokine signaling pathways COL-3 Compound coronavirus COVID-19 COVID-19 patient death in COVID-19 Deceased deregulated disease drug candidate drug repositioning analysis enriched pathway expression Gene Expression identify include Infectious disease inhibition inhibitor Injury investigated lack lung cell Lung injury lung tissue lung tissues MAPK signaling mechanism MMP14 outbreak overlap P-value pathway Patient performed prediction Rac2 reduced Repurposed drug Respiratory failure RHOA SARS-CoV-2 severe respiratory failure signaling pathway significantly target target gene the spike protein TNF signaling treated Treatment treatment for COVID-19 [DOI] 10.12688/f1000research.23996.2 PMC 바로가기 [Article Type] Research Article
Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection시겔라 포함 소포 주위의 액틴 조립은 성공적인 감염을 촉진한다.Article Published on 2020-05-122024-08-22 Journal: Cell Reports [Category] 세균성이질, [키워드] actin cytoskeleton Arp2/3 complex Cdc42 effector proteins host-pathogen interactions intracellular pathogens N-WASP N(ε) fatty acylation Shigella flexneri vacuolar rupture
The Virulence Polysaccharide of Salmonella Typhi Suppresses Activation of Rho Family GTPases to Limit Inflammatory Responses From Epithelial Cells살모넬라 장티푸스의 독성 다당류는 상피 세포의 염증 반응을 제한하기 위해 Rho 가족 GTPase의 활성화를 억제한다.Original Research Published on 2019-05-082024-07-29 Journal: Frontiers in Cellular and Infection Microbiology [Category] 살모넬라증, [키워드] Cdc42 Prohibitin Rac1 Salmonella Typhi Vi polysaccharide [DOI] 10.3389/fcimb.2019.00141 PMC 바로가기 [Article Type] Original Research
Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathwayCek1 경로의 활성화에 의해 칸디다 알비칸스 β(1,3)-글루칸의 노출이 촉진됩니다Research Article Published on 2019-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition AIDS antigenic approach biogenesis bloodstream Cancer patients Candida Candida albican Candida albicans cascades cause Cdc42 Cell cell wall cell wall synthesis decrease detect disrupt Disruption downstream drug exhibit exposure Fungal infection fungal infections fungal pathogens glucan glycosylated GTPase homozygous Hyperactivation immune immune cells immune function immune system increase independent innate immune cell Innate immune cells Intracellular kinase kinases lab lead leads mannan MAPK masking mitogen Mortality mutant Mutation Pathogens pathway Patient Phosphatidylserine polysaccharide promoted protein kinase receptor receptors regulate remodeling responsible Signaling signaling cascade significantly increased synthesis the cell up-regulated upregulated upregulation upstream virulence virulence factor weakened were used wild-type wild-type cell wild-type cells [DOI] 10.1371/journal.pgen.1007892 PMC 바로가기 [Article Type] Research Article
Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolismResearch Paper Published on 2016-10-252023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] ADFP Cdc42 CFL1 HBx SILAM [DOI] 10.18632/oncotarget.12372 PMC 바로가기 [Article Type] Research Paper
Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
Transport of Influenza Virus Neuraminidase (NA) to Host Cell Surface Is Regulated by ARHGAP21 and Cdc42 Proteins *Article Published on 2012-03-232023-06-23 Journal: The Journal of Biological Chemistry [Category] 신종인플루엔자, [키워드] Actin ARHGAP21 Cdc42 GTPase Influenza virus membrane transport neuraminidase Protein Transport Viral protein [DOI] 10.1074/jbc.M111.312959 PMC 바로가기