Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model경증 및 중증 SARS-CoV-2 감염은 K18-hACE2 형질전환 마우스 모델에서 호흡기 및 장내 미생물군유전체 변화를 유도합니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect Antiviral Antiviral treatment Bacteroidete Bacteroidetes cecum change changes in characterized Clinical sign Clinical signs coronavirus COVID-19 COVID-19 pandemic death deaths declining Decreased develop disease dissimilarity dosage dose dose-dependent manner family Firmicute firmicutes groups hACE2 High dose High-dose immune system increasingly independent independent of Infection inhibitor intestinal intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice less lung Lungs M pro mice microbe microbes microbial Microbiome Model mouse presence or absence prevalent Proteobacteria respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 significantly Treatment Verrucomicrobia Viral viral infections virus with infection [DOI] 10.1128/Spectrum.00536-21 PMC 바로가기 [Article Type] Research Article
Lethal infection caused by Tetratrichomonas gallinarum in black swans ( Cygnus atratus )Case Report Published on 2021-05-132023-08-29 Journal: BMC veterinary research [Category] E형 간염, [키워드] T. gallinarum Black Swan cecum China liver [DOI] 10.1186/s12917-021-02894-x PMC 바로가기 [Article Type] Case Report
SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19안드로겐과다증 암컷 마우스의 SARS-CoV-2 바이러스 진입 단백질: PCOS 및 COVID-19가 있는 여성에게 미치는 영향Article Published on 2021-04-252022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 mRNA ACE2 protein ADAM ADAM17 Affect androgen Androgen receptor androgens angiotensin angiotensin I angiotensin I converting enzyme 2 Body body composition body weight Brain cardiometabolic cathepsin cathepsin L causative agent cecum characterized Comorbidities COVID-19 COVID-19 pathology determined by Dihydrotestosterone disorder downregulated dysfunction elevated ELISA Endocrine enzyme fasting fasting glucose fat furin Glucose heart highlight host cell host cells host proteases hyperandrogenism infect kidney lean mass lung male mass mice morphology Mortality mRNA multiple tissue multiple tissues obesity organ systems ovarian Ovary ovulatory pathology Patient Polycystic polycystic ovary Polycystic ovary syndrome priming protease proteases Tmprss2 Protein protein level protein levels qPCR quantified receptor regulate renal risk risk factor Risk factors RT-qPCR SARS-CoV-2 SARS-CoV-2 entry serum severe COVID-19 severity small intestine tissues TMPRSS2 TMPRSS4 treated Treatment upregulated Urine was determined was measured Western-blot with COVID-19 women [DOI] 10.3390/ijms22094472 PMC 바로가기 [Article Type] Article
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditionsAdhatoda Vasica는 전임상 마우스 모델에서 염증 및 저산소 반응을 약화: COVID-19 유사 조건에서 용도 변경 가능성Research Published on 2021-04-062022-08-31 Journal: Respiratory Research [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] adaptive Adaptive immunity Adhatoda vasica Airway inflammation Angiogenesis anti-inflammatory effect Anti-inflammatory effects attenuate Bleomycin Blood coagulation cecum Coagulation condition conditions COVID-19 COVID-19 pneumonia downregulation Effect Extract feature fibrosis growth growth factor herbal medicine HIF-1α highlight hyperinflammation hypoxia hypoxic IL-6 IMPROVE Inflammation Inflammatory ligation lung mice molecular Mouse models murine model murine models naïve observation oral administration pathology pathway phenotype Pneumonia pulmonary fibrosis Puncture reduced Replication response Result SARS-CoV2 Sepsis siRNA supplementary material survival rate tested TGF-β1 thrombosis Transcriptome transforming growth factor treated Treatment upregulation Vero Cell Vero cells Viral Viral load [DOI] 10.1186/s12931-021-01698-9 PMC 바로가기 [Article Type] Research
Chicken cecal DNA methylome alteration in the response to Salmonella enterica serovar Enteritidis inoculation살모넬라 엔테리티디스 접종에 대한 반응에서 닭 맹장 DNA 메틸롬 변화Research Article Published on 2020-11-232024-07-29 Journal: BMC Genomics [Category] 살모넬라증, [키워드] cecum chicken DNA methylation Salmonella enterica serovar Enteritidis Whole-genome bisulfite sequencing [DOI] 10.1186/s12864-020-07174-w PMC 바로가기 [Article Type] Research Article
IgA gene expression and quantification of cecal IgA+, IgM+, and CD4+ cells in chickens treated with EFAL41 and infected with Salmonella EnteritidisEFAL41로 처리되고 Salmonella Enteritidis에 감염된 닭에서 IgA 유전자 발현 및 맹장 IgA+, IgM+, CD4+ 세포의 정량화journal-article Published on 2015-09-012024-07-30 Journal: Nat New Biol [Category] 살모넬라증, [키워드] cecum chicken Enterococcus faecium Lymphocytes Salmonella infection [DOI] 10.1016/j.acthis.2015.06.004 [Article Type] journal-article