Identification of FasL as a crucial host factor driving COVID-19 pathology and lethalityArticle Published on 2024-03-212024-09-05 Journal: Cell Death and Differentiation [Category] update2024, [키워드] Acute inflammation Cell death and immune response Immunopathogenesis [DOI] 10.1038/s41418-024-01278-6 PMC 바로가기 [Article Type] Article
Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β productionArticle Published on 2024-02-062024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Autoinflammatory syndrome Cell death and immune response Inflammasome Translational research [DOI] 10.1038/s41467-024-44990-0 PMC 바로가기 [Article Type] Article
Differential activation of programmed cell death in patients with severe SARS-CoV-2 infectionarticle Published on 2023-11-202024-09-05 Journal: Cell Death Discovery [Category] update2024, [키워드] Cell death and immune response Infection viral infection [DOI] 10.1038/s41420-023-01715-4 PMC 바로가기 [Article Type] article
Inhibition of Toll-like receptor 4 and Interleukin-1 receptor prevent SARS-CoV-2 mediated kidney injuryarticle Published on 2023-08-102024-09-05 Journal: Cell Death Discovery [Category] update2024, [키워드] Acute kidney injury Antimicrobial responses Cell death and immune response [DOI] 10.1038/s41420-023-01584-x PMC 바로가기 [Article Type] article
Balancing the functions of DNA extracellular traps in intracellular parasite infections: implications for host defense, disease pathology and therapyarticle Published on 2023-07-202024-09-05 Journal: Cell Death & Disease [Category] update2024, [키워드] Cell death and immune response chronic inflammation [DOI] 10.1038/s41419-023-05994-8 PMC 바로가기 [Article Type] article
Moonlighting chromatin: when DNA escapes nuclear controlarticle Published on 2023-02-082024-09-05 Journal: Cell Death & Differentiation [Category] update2024, [키워드] Cell death and immune response Inflammation [DOI] 10.1038/s41418-023-01124-1 PMC 바로가기 [Article Type] article
Cortical-blood vessel assembloids exhibit Alzheimer’s disease phenotypes by activating glia after SARS-CoV-2 infectionarticle Published on 2023-01-252024-09-05 Journal: Cell Death Discovery [Category] update2024, [키워드] Acute inflammation Cell death and immune response tissue engineering [DOI] 10.1038/s41420-022-01288-8 PMC 바로가기 [Article Type] article
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cellsArticle Published on 2021-09-232022-10-04 Journal: Cell Death & Disease [Category] 신약개발, [키워드] Activation anti-TNF Apoptosis autoinflammatory disease biochemical biopsy canonical CASP8 caspase caspase-8 cell death Cell death and immune response contribute Critical Crohn's disease Crohn’s disease cytokine death dependence driven by driver epithelial Ex vivo feature Genetic Gut Host IBD IEC IFN-γ immunopathology independent induce Inflammatory bowel disease inhibitor interferons intestinal epithelial cell Intestinal Organoids involved JAK inhibitor kill killing kinase loss-of-function mechanisms MLKL mucosal necroptosis Organoid pathway required retained sustained synergistic T cells therapeutic efficacy TNF-α TNFR1 Tumour-necrosis factors ZBP1 [DOI] 10.1038/s41419-021-04151-3 PMC 바로가기 [Article Type] Article
Inflammasome activation at the crux of severe COVID-19Review Published on 2021-08-092023-06-15 Journal: Nature reviews. Immunology [Category] Fulltext, MERS, [키워드] Cell death and immune response Inflammasome [DOI] 10.1038/s41577-021-00588-x PMC 바로가기 [Article Type] Review
Primidone blocks RIPK1-driven cell death and inflammationArticle Published on 2020-12-032022-10-04 Journal: Cell Death and Differentiation [Category] MERS, SARS, 신약개발, [키워드] Activation block cell death Cell death and immune response condition COVID-19 patients cytokine release Cytokine release syndrome FDA-approved drug hospitalized patient humans hyperinflammation hyperinflammatory state IMPROVE in vitro Inflammation inhibitor kidney multi-organ failure murine model Myocardial infarction organ damage positive Prevent Primidone Protein recent Regulated cell death respiratory tract RIPK1 SARS-COV-2 infection searched Shock stroke syndrome systemic inflammatory response tested therapy Translational research [DOI] 10.1038/s41418-020-00690-y PMC 바로가기 [Article Type] Article