Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entryarticle Published on 2024-04-182024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] Aggregatibacter actinomycetemcomitans cell entry cellugyrin cytolethal distending toxin pathogen SARS-CoV-2 synaptic-like microvesicles synaptogyrin-2 [DOI] 10.3389/fcimb.2024.1334224 PMC 바로가기 [Article Type] article
Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen유전체 전반에 걸친 CRISPR 녹아웃 스크린을 기반으로 한 소 herpesvirus 유형 1의 후보 숙주 세포 진입 인자 검증Article Published on 2024-02-152024-08-26 Journal: Viruses [Category] 폴리오, [키워드] BoHV-1 cell entry COG complex CRISPR/Cas9 Golgi apparatus heparan sulfate receptors
LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virusarticle Published on 2023-01-162024-09-05 Journal: mBio [Category] update2024, [키워드] attenuated CDV cell entry CRISPR/Cas9 KO screen LRP6 receptor [DOI] 10.1128/mbio.03114-22 PMC 바로가기 [Article Type] article
Development of Fluorescence-Tagged SARS-CoV-2 Virus-like Particles by a Tri-Cistronic Vector Expression System for Investigating the Cellular Entry of SARS-CoV-2Article Published on 2022-12-192023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] ACE2 cell entry endocytosis fluorescence labeling fusion Rab5 SARS-CoV-2 Virus-like particle [DOI] 10.3390/v14122825 PMC 바로가기
SARS-CoV-2 cell entry beyond the ACE2 receptorArticle Published on 2022-11-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor AGTR2 ASGR1 Asymptomatic auxiliary B.1.1.529 B.1.1.7 B.1.617.1 B.1.617.2 binding carried CD147 CD26 cell entry cell surface receptors CLEC4G Cochrane Library COVID19 Delta Delta+ develop English enzyme erythrocyte Evidence explain facilitate host cell Hypoxemia Infection KREMEN1 LDLRAD3 membrane protein MeSH term neuropilin omicron organs Protein receptor receptors S protein SARS-CoV-2 SARS-CoV-2 cell SARSCoV-2 selected target therapeutic agent tissue tropism TMEM30A Transmission variants of SARS-CoV-2 viral entry virus entry [DOI] 10.1007/s11033-022-07700-x PMC 바로가기
Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screeningArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 변종, 치료제, [키워드] amino acid residue antiviral drug binding binding sites. Cefixime Ceftazidime cell entry Cephalosporin derivative clinical evaluation coronavirus 2 Critical derivative drug Drug screening example hACE2 human Angiotensin-converting enzyme identification Infection inhibited Interaction key amino acid live SARS-CoV-2 molecular docking Mutation peptide Pseudotyped virus pseudovirus RBD Receptor binding domain respiratory Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD Support targets tested the RBD the spike protein variants virus was determined wild type wildtype Wuhan [DOI] 10.1016/j.virusres.2022.198915 PMC 바로가기
Mulberry Component Kuwanon C Exerts Potent Therapeutic Efficacy In Vitro against COVID-19 by Blocking the SARS-CoV-2 Spike S1 RBD:ACE2 Receptor InteractionArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] ACE2 ACE2 receptor acute respiratory syndrome addition anticipated antiviral efficacy blocker blocking cell entry Clinical use Combination component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated develop disrupting docking drugs effective Effectiveness Efficacy effort ELISA ENhance Future HEK293T cells in silico Infection inhibit inhibitor inhibitors Interaction isolate kuwanon C lack mechanism of action Morus Alba Morus alba L. potent Prevent Pseudotyped virus receptor Replication RNA SARS-CoV-2 SARS-CoV-2 spike several limitation severe acute respiratory syndrome coronavirus 2 significantly spike Spike protein spike S1 RBD supported target tested the SARS-CoV-2 Therapies Vero cells [DOI] 10.3390/ijms232012516 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronavirusesArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis antiviral drug Biological functions cell entry characterization characterized Coronavirus-2 D614G domains FIVE functional glycosylated help less membrane fusion mutant N-glycosylation O-glycosylation Recombinant spike protein S proteins S1 protein S1 subunit SARS-CoV-2 Sialylation spike Spike protein Spike proteins Vaccine β-coronavirus β-coronavirus. β-CoV β-CoVs [DOI] 10.1016/j.aca.2022.340394 PMC 바로가기
Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2Article Published on 2022-10-062022-11-16 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affinity Analysis B.1.617.2 Beta bind binding binding affinity cell entry complex complex structure coronavirus Coronaviruses Delta Efficiency equine Equus functional Gamma hACE2 HCoV-NL63 HeLa cells high affinity horse human ACE2 indicated Infection infection assay molecular basis Mutation provide pseudovirus pseudovirus infection RBDs receptor Receptor binding domain Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 variant significantly increased spike receptor-binding domain the RBD the SARS-CoV-2 the spike protein Transmission zoonotic [DOI] 10.1016/j.str.2022.07.005 PMC 바로가기