TGF-β signaling: critical nexus of fibrogenesis and cancerReview Published on 2024-06-262024-09-05 Journal: Journal of Translational Medicine [Category] update2024, [키워드] Cancer Cell signaling fibrosis precision medicine TGF-β theranostics [DOI] 10.1186/s12967-024-05411-4 PMC 바로가기 [Article Type] Review
Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling networkVirus-Cell Interactions Published on 2023-11-202024-09-05 Journal: Journal of virology [Category] update2024, [키워드] Cell signaling COVID-19 DCLK1 DCLK1-IN-1 host-virus interaction interactome pathology replication-transcription SARS-CoV-2 [DOI] 10.1128/jvi.01194-23 PMC 바로가기 [Article Type] Virus-Cell Interactions
p38MAPK/MK2 signaling stimulates host cells autophagy pathways to restrict Salmonella infectionarticle Published on 2023-09-302024-09-01 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] autophagy Cell signaling Infection MEFs MK2 p38MAPK Salmonella Xenophagy [Article Type] article
Emerging evidence for poxvirus-mediated unfolded protein response: Lumpy skin disease virus maintains self-replication by activating PERK and IRE1 signalingArticle Published on 2023-05-012023-06-10 Journal: FASEB journal : official publication of the Federa [Category] 원숭이두창, [키워드] Cell signaling endoplasmic reticulum stress lumpy skin disease virus poxvirus unfolded protein response [DOI] 10.1096/fj.202300028R
Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon SignalingArticle Published on 2022-09-282023-06-22 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] avian viruses Cell signaling duck influenza viruses interferons Reservoir host TRIM25 ubiquitination viral pathogenesis [DOI] 10.1128/jvi.00776-22 PMC 바로가기
MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapiesMiRNA-SARS-CoV-2 대화 및 전향적인 항-COVID-19 치료법Review Published on 2022-09-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse effect adverse effects Affect antiviral response approach approved Biomarker caused Cell signaling chance Clinical significance Comorbidities coronavirus Coronavirus-2 country COVID-19 COVID-19 illness COVID-19 infection COVID-19 pathogenesis COVID-19 patient Critical death detect differential expression disease disease onset disease pathology effort etiology expression FDA focus Host host cell host inflammatory response host miRNA host miRNAs identify Infection life cycle microRNA miRNA miRNAs molecular interaction non-coding RNA offer pathogen Pathogen-host interaction patients with COVID-19 post-transcriptionally quest reduce respiratory respond RNA RNA silencing SARS Coronavirus SARS coronavirus 2 SARS coronavirus 2. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity Signaling target gene the SARS-CoV-2 virus therapy treat Treatment Viral viral miRNA viral miRNAs [DOI] 10.1016/j.lfs.2022.120761 PMC 바로가기 [Article Type] Review
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy임신 중 자간전증 및 COVID-19의 내피 및 혈관 신생 프로파일의 차이 및 유사성Article Published on 2022-08-012022-08-31 Journal: American journal of obstetrics and gynecology [Category] MERS, 바이오마커, 진단, [키워드] absence activate addition Adhesion Molecule alteration Analysis Angiogenesis angiogenic factors angiopoietin Antigen Biomarker Biomarkers C5b9 Cell cell membrane cell membranes Cell signaling change changes in circulating Coagulation Coagulopathy component Concentration Control controls COVID-19 COVID-19 infection COVID-19 patients Culture demonstrated difference differential diagnosis differentiation disease disorder endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction evaluated exhibited expected explained expression Extracellular Extracellular matrix group growth growth factor healthy heparan sulfate hypertensive hypertensive disorders of pregnancy Immunoblots immunofluorescence in some in vitro increase in Infection Inflammation inflammatory signaling innate immune response intercellular intercellular adhesion molecule less lysate lysates Mild mitogen-activated protein kinase Necrosis neutrophil Neutrophil extracellular trap Neutrophil extracellular traps normotensive overexpression Pathways Patient Phosphorylation placental placental growth factor preeclampsia Pregnancy pregnant women Principal component principal component analysis profile profiles Protein protein kinase receptor reduced reduction reduction in SARS-CoV-2 sera severe COVID-19 severe COVID-19 patient signaling pathway significant increase significantly increased Signs and symptoms similarity soluble fms-like tyrosine kinase-1 soluble tumor necrosis factor-α receptor I Spectrum statistical analysis statistically Study design sulfate Symptom Tumor tumor necrosis tumor necrosis factor-α tyrosine variable variance vascular cell adhesion von Willebrand disease von Willebrand factor with COVID-19 women [DOI] 10.1016/j.ajog.2022.03.048 PMC 바로가기 [Article Type] Article
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
Facile discovery of surrogate cytokine agonistsArticle Published on 2022-04-142023-07-08 Journal: Cell [Category] COVID19(2023년), [키워드] bispecific antibodies Cell signaling cytokine engineering interferon interleukin-10 interleukin-2 SARS-CoV-2 scFv VHH [DOI] 10.1016/j.cell.2022.02.025 PMC 바로가기
A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung CellsSARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다Article Published on 2022-01-262022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle [DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article