Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike설계된 이황화물은 잠긴 SARS-CoV-2 스파이크의 구조적 역학을 보여줍니다Article Published on 2022-07-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] Acidic Alter Analysis cellular compartment change changes in conformation conformational change conformations D614G D614G mutation Disulfide disulfide bond domain extracellular space functional high-resolution structure hinge interact modulate Mutation Neutral pre-fusion Protein provide RBD Receptor binding domain Regulation reveal SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spikes sequence Structure structures transition variants of concern viral fitness virion virus wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1010583 PMC 바로가기 [Article Type] Article
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
Secretory Vesicles Are the Principal Means of SARS-CoV-2 EgressArticle Published on 2021-08-102022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition analysed Antiviral strategies biosynthetic Cell cellular compartment coronavirus Coronaviruses COVID-19 extracellular space HIV Hypothesis immunodeficiency in viral infected with SARS-CoV-2 late stage lysosome macrophages mechanism Microscope other coronaviruses Particle plasma membrane principal released SARS-CoV-2 secretory secretory pathway serial sections suggested TEM the SARS-CoV-2 thought transmission electron microscopy Vero Cell Vesicle vesicles virus virus egress virus release [DOI] 10.3390/cells10082047 PMC 바로가기 [Article Type] Article
Chemistry and biology of ferritin페리틴의 화학 및 생물학Review Published on 2021-05-122022-09-11 Journal: Metallomics : integrated biometal science [Category] SARS, 바이오마커, [키워드] Biological functions Biology Biomarker Cancer Cell cell metabolism cellular cellular compartment Chemical biology Chemistry coronavirus disease Coronavirus disease 2019 described disease Diseases essential element ferritin Ferroptosis function functions impairment implicated iron iron homeostasis metabolism Protein reactivity required Research secreted variety [DOI] 10.1093/mtomcs/mfab021 PMC 바로가기 [Article Type] Review