A pilot phase Ib/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: First experience from AfricaClinical Trial Published on 2022-07-012022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] 24 hour absence benefit cellular proliferation clinical benefit clinical trial Complete condition conducted COVID-19 CRP Cytokine storm D-dimer Day death defined demonstrated died discharge discharged dose Efficacy elevated enrolled feasibility feasible fraction High-resolution HRCT identify Inflammatory marker inhibit investigator-initiated Kenya low dose lung management mechanical ventilation median time on mechanical ventilation oxygen Oxygen requirement Oxygenation Patient patients PCR Pneumonia polymerase chain primary endpoint progressed radiation therapy remained resources SAE Safe secondary endpoint Sepsis severe COVID-19 Severe COVID-19 pneumonia the patient therapy Toxicity treat treated Treatment Trial university Vaccine were excluded [DOI] 10.1371/journal.pone.0270594 PMC 바로가기 [Article Type] Clinical Trial
Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions인간 신장 회전 타원체 및 단층은 SARS-CoV-2 신장 상호 작용에 대한 통찰력을 제공합니다Article Published on 2021-09-012022-09-11 Journal: Journal of the American Society of Nephrology : JA [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey AKI baseline level cause Cell cell death cellular proliferation clone Col1a1 Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cultures cytopathic cytopathic damage Cytopathic effect dedifferentiation demonstrated disease Elevation epithelial cell epithelial cells Ex vivo exhibited fibrosis green monkey help higher infectivity Human human kidney human tubular kidney cells identity infect Injury insight Interaction interferon interferon pathway Intervention kidney Kidney disease kidney infection kidney spheroids kidney stem cells less LRP2 mechanisms monolayer monolayers morbidity outcome patients with COVID-19 presenting pulmonary involvement reduction in renal renal progenitors renal tubular renal tubular epithelial cells. Replication replication of SARS-CoV-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus SNAI2 Spheroid STAT6 Support Symptom the disease tubular cell Vero E6 viral entry viral infection virus with COVID-19 [DOI] 10.1681/ASN.2020111546 PMC 바로가기 [Article Type] Article
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular MechanismsReview Published on 2021-06-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activate activated Activation alveolar appear approved attenuate autophagy canonical Cell cell type cellular cellular proliferation change characterized clinical trial compassionate use Cytokines described disorders distribution Endoplasmic reticulum epithelial Evidence excessive inflammation expression FGF fibroblast fibrosis growth factor idiopathic pulmonary fibrosis (IPF) IL-11 IL-13 IL-6 ILD in vitro in vivo model indicate inhibit Interaction interstitial inflammation interstitial lung disease (ILD) isoform isoforms JAK inhibitor JAK/STAT JAK/STAT pathway JAK2/STAT3 Janus kinases (JAK) lung Lung disease lung disorder Lung fibrosis lung tissue molecular monoclonal antibody over-expressed pathway Pathways PDGF Phosphorylation predominant proliferation pulmonary fibrosis recent role SARS-CoV-2 virus signal transducer and activator of transcription (STAT) small molecule Stress TGF-β1 [DOI] 10.3390/ijms22126211 PMC 바로가기 [Article Type] Review
Antiviral properties of placental growth factors: A novel therapeutic approach for COVID-19 treatmentArticle Published on 2020-08-062023-06-14 Journal: Placenta [Category] MERS, SARS, [키워드] Anti-inflammatory cellular proliferation immunomodulatory novel coronavirus COVID-19 Placental extract tissue regeneration [DOI] 10.1016/j.placenta.2020.07.033 PMC 바로가기 [Article Type] Article
The Role of Infected Cell Proliferation in the Clearance of Acute HBV Infection in HumansArticle Published on 2017-11-182023-06-02 Journal: Viruses [Category] B형 간염, [키워드] cellular proliferation cytokine-mediated cure of infected cells Hepatitis B virus hepatocyte turnover [DOI] 10.3390/v9110350 PMC 바로가기 [Article Type] Article
Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferationKi67의 새로운 적용을 통해 항원 특이적 시험관 내 림프 증식을 정량화하다Research Paper Published on 2010-10-312024-08-16 Journal: Journal of Immunological Methods [Category] 파상풍, [키워드] cellular proliferation clinical immunology Ki67 OG, Oregon Green PPD, purified protein derivative T cells TT, tetanus toxoid Vaccine [DOI] 10.1016/j.jim.2010.08.007 PMC 바로가기 [Article Type] Research Paper