In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated TherapeuticsReview Published on 2024-03-222024-09-05 Journal: Pharmaceutics [Category] update2024, [키워드] cellular uptake dendrimers drug delivery gene delivery in vivo Theragnostic [DOI] 10.3390/pharmaceutics16040439 PMC 바로가기 [Article Type] Review
Zwitterionic peptides: Tunable next-generation stealth nanoparticle modificationsArticle Published on 2023-03-292024-09-05 Journal: Bioactive Materials [Category] update2024, [키워드] cellular uptake Nanoparticles Peptide design Protein corona surface functionalization [DOI] 10.1016/j.bioactmat.2023.03.020 PMC 바로가기 [Article Type] Article
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice야생형 마우스에서 비활성화된 SARS-CoV-2의 생체분포 및 세포 내재화Article Published on 2022-07-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 receptors administration analyzed angiotensin attachment Brain can not caveolin cell entry receptor cell line cellular cellular uptake clathrin Consensus conserved expression heart help heparan sulfate heparan sulfate proteoglycans heparin human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo inactivated infected with SARS-CoV-2 Inflammation internalization intravenous Intravenous administration mammalian mice molecular interaction motif mouse Muridae murine organ Proteoglycan raised reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 receptors Spike protein sulfate syndecan syndecan-4 syndecans syndecans. tissue TNF-α transmembrane various tissues wild-type [DOI] 10.3390/ijms23147609 PMC 바로가기 [Article Type] Article
In vivo fate and intracellular trafficking of vaccine delivery systemsArticle Published on 2022-05-102023-06-15 Journal: Advanced drug delivery reviews [Category] MERS, [키워드] cellular uptake endosomal escape In vivo fate intracellular trafficking Translation enhancement Vaccine delivery system [DOI] 10.1016/j.addr.2022.114325 PMC 바로가기 [Article Type] Article
Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2SARS-CoV-2에 감염된 상피 조직 패치에 대한 항바이러스 타이밍, 효능 및 이질성 효과의 다중 스케일 모델Article Published on 2022-03-142022-09-11 Journal: Viruses [Category] SARS, 치료제, [키워드] Affect agent agent-based model Antiviral antiviral therapies antiviral therapy Cell cell-to-cell variability cellular cellular metabolism cellular uptake dosage dose Effect Efficacy epithelial Epithelial Tissue Frequency homogeneous include Infection likelihood lowest lung tissue metabolism metabolite Model mPBPK multiscale model outcome outcomes parameters patch permeability pharmacokinetic potency predict Remdesivir SARS-CoV-2 significantly Super-spreader tissue tissue model treat Treatment treatment initiation Treatment outcome Variability Variation viral infection viral infections virtual tissue simulation. [DOI] 10.3390/v14030605 PMC 바로가기 [Article Type] Article
Syndecan-4 Is a Key Facilitator of the SARS-CoV-2 Delta Variant’s Superior TransmissionSyndecan-4는 SARS-CoV-2 Delta 변형의 우수한 전송의 핵심 촉진자입니다.Article Published on 2022-01-122022-09-10 Journal: International Journal of Molecular Sciences [Category] 변종, 유전자 메커니즘, [키워드] ACE2 added addition attachment B.1.617 being block cellular cellular entry cellular uptake complexity COVID-19 Delta delta variant domain driver electrostatic ENhance exogenously expression facilitator heparan sulfate heparan sulfate proteoglycans heparin higher affinity in vitro Infection interactions isoform knockdown Lineage lung Modification molecular molecular interaction molecular mechanism molecular mechanisms mutated Mutation positive Protein Proteoglycan pseudoviruses reduce SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant Specific spike glycoprotein Spike protein Spread sulfate Superior syndecan syndecan-4 the SARS-CoV-2 threat Threats Transmission vaccination Viral transmission virus wild-type [DOI] 10.3390/ijms23020796 PMC 바로가기 [Article Type] Article
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19GS-441524의 세포 흡수 및 세포 내 인산화 : Covid-19에 대한 효과에 대한 영향Review Published on 2021-07-142022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] adenosine adenosine analogs adenosine kinase adenosine levels adenosine transporters alveolar cell alveolar cells alveoli anticancer Antiviral approval cellular cellular uptake clinical effectiveness COVID-19 Critical decrease decreased expression disease effective Effectiveness epithelial cell epithelial cells expressed expression Extracellular GS-441524 healthy hypoxia illnesses Increases increases in Inflammation Intracellular knowledge lead limit Lungs monophosphate nucleoside occur outcome parent nucleoside pharmacokinetic Phosphorylation pneumocyte Pneumocytes protein expression reduced Remdesivir SARS-CoV-2 severe inflammation therapeutic tissue tissues Treatment treatment of COVID-19 triphosphate uptake [DOI] 10.3390/v13071369 PMC 바로가기 [Article Type] Review
HBV Pre-S1-Derived Myristoylated Peptide (Myr47): Identification of the Inhibitory Activity on the Cellular Uptake of Lipid NanoparticlesArticle Published on 2021-05-172023-06-02 Journal: Viruses [Category] B형 간염, [키워드] apolipoprotein E (ApoE) cellular uptake HBV surface antigen (HBsAg) Hepatitis B virus (HBV) liposomes Myr47 lipopeptide sodium taurocholate cotransporting polypeptide (NTCP) [DOI] 10.3390/v13050929 PMC 바로가기 [Article Type] Article
Morphological features and pathogenicity of mutated canine influenza viruses from China and South KoreaArticle Published on 2020-07-012023-06-23 Journal: Transboundary and emerging diseases [Category] 신종인플루엔자, [키워드] canine influenza virus cellular uptake morphology pathogenicity [DOI] 10.1111/tbed.13494
Tetanus toxoid-loaded cationic non-aggregated nanostructured lipid particles triggered strong humoral and cellular immune responses파상풍 톡소이드가 함유된 양이온성 비응집 나노구조 지질 입자는 강력한 체액성 및 세포성 면역 반응을 유발했습니다.journal-article Published on 2016-04-022024-07-30 Journal: Journal of Microencapsulation [Category] 파상풍, [키워드] Apoptosis cellular immunity cellular uptake cytotoxicity Humoral immunity non-aggregated cationic lipid nanoparticles tetanus toxoid [DOI] 10.3109/02652048.2016.1169324 [Article Type] journal-article