A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infectionArticle Published on 2022-09-152024-08-29 Journal: Cell Chem Biol [Category] 말라리아, [키워드] CENPJ CRISPR-Cas9 Genome-wide Golgi liver-stage malaria microtubule MTOC Plasmodium vesicular trafficking.
Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란Research Article Published on 2012-11-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells [DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article