Mapping immunological and host receptor binding determinants of SARS-CoV spike protein utilizing the Qubevirus platformResearch Article Collection: Virology Published on 2023-11-152024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] A1 minor coat protein anti-S antibody chimeric Qubevirus rhACE2 SARS-CoV spike fragment [DOI] 10.1016/j.jbc.2023.105460 PMC 바로가기 [Article Type] Research Article Collection: Virology
Design and characterization of chimeric Rabies-SARS-CoV-2 virus-like particles for vaccine purposesarticle Published on 2023-05-012024-09-05 Journal: Applied Microbiology and Biotechnology [Category] update2024, [키워드] chimeric rabies RBD spike VLP [DOI] 10.1007/s00253-023-12545-w PMC 바로가기 [Article Type] article
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant variant of concern Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
Evidence of co-infections during Delta and Omicron SARS-CoV-2 variants co-circulation through prospective screening and sequencingArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis chimeric circulation Co-infection collected COVID-19 Delta Delta and Omicron VOC Epidemic epidemiologically evidence of France generate Genetic Health Infection K417N L452R Mutation nasopharyngeal sample omicron Pandemics pathogenic patients PCR assay polymorphism primer sets profile Recombination recombination event Respiratory samples S-gene mutation Sample SARS-CoV-2 SARS-CoV-2 co-infection SARS-CoV-2 genome SARS-CoV-2 variant screened sequence Sequencing single nucleotide Single nucleotide polymorphism Single nucleotide polymorphism screening SNP SNPs submitted Surveillance variant virus VoC was performed WGS whole genome Whole genome sequencing [DOI] 10.1016/j.cmi.2022.06.030 PMC 바로가기
Preparation and pre-clinical evaluation of flagellin-adjuvanted NOM vaccine candidate formulated with Spike protein against SARS-CoV-2 in mouse modelArticle Published on 2022-10-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] 3D structure acute respiratory syndrome Analysis anti-S Antigen Antisera bind Cell Cell-mediated immune responses chimeric China Cluster coronavirus cytokine develop docking effective elicit ELISA ENhance evaluated expressed flagellin groups humoral IFN-γ IgG IL-10 IL-17 IL-22 IL-6 immune response immunoinformatics indicated Infection Interaction mice Ni-NTA NOM protein ORF3a outbreak performed pneumonia case preparation promoted Protein purified raised receptor S protein Salmonella SARS-CoV-2 significantly increased spike spleen TLR5 TNF-α Total vaccination Vaccine vaccine candidate vaccine candidates was selected were assessed Wuhan [DOI] 10.1016/j.micpath.2022.105736 PMC 바로가기
The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodiesArticle Published on 2022-10-012022-11-15 Journal: Haematologica [Category] 진단, [키워드] activate Activation addition adenoviral vector vaccine antibodies antibody Autoimmune bind chimeric COVID-19 COVID-19 vaccines demonstrated Effect epitope Fc fragment granulocyte help IgG antibodies immune IMPROVE induce inhibit interact Mouse models NETosis neutralize Neutrophils overlapping Pathogenesis pathogenic pathophysiology PF4 Platelet platelet activation Prevent prothrombotic receptors recognize Support thrombosis thrombotic Trigger Whole blood [DOI] 10.3324/haematol.2021.280251 PMC 바로가기
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza virusesArticle Published on 2022-09-022022-10-06 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 진단, [키워드] analyses antibody antiviral drug benefit chimeric conserved cross-neutralization cross-neutralizing cross-protection eight engage epitope overlapping Evidence H1N1 H5N1 identification in vivo Influenza influenza vaccines Influenza virus mAb molecular monoclonal antibody neutralization Neutralizing activity offer pandemic receptor binding site residue Surface glycoprotein target Tolerance Vaccine viral challenge virus virus entry viruses [DOI] 10.1038/s41467-022-32926-5 PMC 바로가기 [Article Type] Article
The Rv3874-Rv3875 chimeric protein shows a promiscuous serodiagnostic potential for tuberculosisArticle Published on 2022-09-012022-11-15 Journal: Tuberculosis (Edinburgh, Scotland) [Category] 진단, [키워드] addition Antigen CEP Fusion chimeric cloned COVID-19 death Diagnostic method diagnostic potential early diagnosis EC Skin test ELISA epitope Escherichia coli BL21 expressed female HIV in silico analysis male subject molecular Mycobacterium tuberculosis novel Novel epitope prediction polyclonal antibody positive preliminary findings Protein purified reported secondary structure sensitivity serodiagnostic serum serum sample skin statistical Tuberculosis [DOI] 10.1016/j.tube.2022.102253 PMC 바로가기
Cleavage-Responsive Biofactory T Cells Suppress Infectious Diseases-Associated HypercytokinemiaArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] activate administration Alpha Blood chimeric cleavage cleavage site coronavirus disease COVID-19 digestion Diseases domain drug endothelial engineered blood vessel engineered T cell enzyme EPCR Express expressing hypercytokinemia immune cells in vivo induce Infectious disease lentiviral system lung tissue multiple organ failure Necrosis overcome peptide Prevent Protein receptor Release Sepsis suppress T cell therapeutic thrombin receptor TRAP Treatment Vascular damage vessel [DOI] 10.1002/advs.202201883 PMC 바로가기
Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion proteinRBD-뉴클레오캡시드 융합단백질을 이용한 관심대상 야생형 및 SARS-CoV-2 변이체에 대한 중화항체 비의존성 면역 촉진Article Published on 2022-08-172022-09-11 Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] ablated angiotensin antibody Antigen B cell B cells Blood CD4 CD8 chimeric circumvent Clinical outcome convertase COVID-19 convalescent donors COVID-19 vaccine COVID-19 vaccines Delta Depletion detectable effector T cell effector T cells elicit elicited experimental model experimental models fusion protein generate hamster IFN-γ Immune escape Immunity immunization IMPROVE inactivated indicated individual Infection infection with SARS-CoV-2 less lethality levels of antibody Lung inflammation mice NAbs Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid omicron promote promotion PROTECT Protein protocol protocols RBD RBD protein Receptor binding domain reduction robust SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 vaccine SARS-CoV-2 variant shown spike Spin T cell T cells transferred vaccination Vaccine variants variants of concern Viral Viral load virus wild type wild-type [DOI] 10.1038/s41467-022-32547-y PMC 바로가기 [Article Type] Article