CARs derived from broadly neutralizing, human monoclonal antibodies identified by single B cell sorting target hepatitis B virus-positive cellsImmunology Original Research Published on 2024-04-222024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] Broad neutralization chimeric antigen receptor HBsAg hepatitis B virus envelope proteins Human monoclonal antibody linear epitope single B cell sorting tonic signaling [DOI] 10.3389/fimmu.2024.1340619 PMC 바로가기 [Article Type] Immunology Original Research
Chimeric antigen receptor T cell and regulatory T cell therapy in non-oncology diseases: A narrative review of studies from 2017 to 2023Immunotherapy - Other Published on 2023-10-092024-09-05 Journal: Human vaccines & immunotherapeutics [Category] update2024, [키워드] CAR-T cell therapy chimeric antigen receptor chimeric T cell receptors Immunotherapy non-oncology diseases [DOI] 10.1080/21645515.2023.2251839 PMC 바로가기 [Article Type] Immunotherapy - Other
Robust immune responses to SARS-CoV-2 in a pediatric patient with B-Cell ALL receiving tisagenlecleucelArticle Published on 2022-09-012023-07-08 Journal: Pediatric hematology and oncology [Category] COVID19(2023년), [키워드] CD19 directed therapy chimeric antigen receptor SARS-CoV-2 T-cell Response tisagenlecleucel. [DOI] 10.1080/08880018.2022.2035864
Prevention and treatment of COVID-19 in patients with benign and malignant blood disordersReview article Published on 2022-08-012022-10-05 Journal: Best Practice & Research Clinical Haematology [Category] 변종, 치료법, 치료제, [키워드] B-cell Blood Blood cancer Cell chimeric antigen receptor Community complications COVID-19 COVID-19 in patient disease disorder hematologic Hemoglobinopathies high risk immunization immunosuppressed patient Immunosuppression initial lymphoid malignancies malignancy moderate NIH pathology Patient prevention receive regimen risk Safe SARS-CoV-2 severe immunosuppression T-cell Therapies therapy threshold Treatment Vaccine while [DOI] 10.1016/j.beha.2022.101375 [Article Type] Review article
Natural killer cells in antitumour adoptive cell immunotherapy Reviews Published on 2022-07-252022-10-05 Journal: Nature Reviews Cancer [Category] 바이오마커, 임상, 치료기술, 치료법, [키워드] anticancer approach Cancer CAR Cell cells chimeric antigen receptor cytokine cytokine production cytotoxicity driving Efficacy evaluate expression identify immune response Immunity Immunotherapy infected cell innate lymphoid cell intrinsic mechanism modulate natural natural killer cell NK cell NK cell-based therapy NK cells Patient persistence review specificity Strategy T cell therapy Treatment turn unique [DOI] 10.1038/s41568-022-00491-0 [Article Type] Reviews
Infectious complications, immune reconstitution, and infection prophylaxis after CD19 chimeric antigen receptor T-cell therapy Reviews Published on 2022-07-152022-10-05 Journal: Bone marrow transplantation [Category] 치료제, [키워드] CAR CD19 Cell chimeric antigen receptor clinically complications Cytokine release syndrome disease Evidence Factor hematologic Hypogammaglobulinemia immune immune function incidence increasingly Infection less lymphoid malignancies Patient patients Prophylaxis recipient risk factor Side effect standard treatment T-cell T-cells therapy Treatment undergo Vaccination strategy [DOI] 10.1038/s41409-022-01756-w [Article Type] Reviews
Immune Responses to SARS-CoV-2 Vaccination in Young Patients with Anti-CD19 Chimeric Antigen Receptor T Cell-Induced B Cell Aplasia항-CD19 키메라 항원 수용체 T 세포 유도 B 세포 무형성증이 있는 젊은 환자에서 SARS-CoV-2 백신 접종에 대한 면역 반응Article Published on 2022-07-012022-09-11 Journal: Transplantation and cellular therapy [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Acute lymphoblastic leukemia acute respiratory syndrome acute respiratory syndrome coronavirus advent adverse events age Anti-CD19 Anti-CD19 CAR T cell-induced B cell aplasia anti-S Antigen antigen receptor aplasia B cell CAR CAR T cell therapy CD19 CD4 CD4/CD8 Cell therapy cellular immunity chimeric antigen receptor Cohort coronavirus coronavirus disease coronavirus disease 19 COVID-19 Cytometry deficiency diagnosed disease Endpoint Exacerbation exhibited expected flow cytometry grade 3 Graft-versus-host disease GVHD healthy healthy controls humoral Humoral response humoral responses Immune cell immune response Immunoglobulin Immunoglobulin G incidence individual induce Infection leukemia Lymphoblastic leukemia lymphocyte Lymphocyte count Lymphocyte subsets mRNA vaccine Mutation Omicron variant outcome Patient precursor primary endpoint Prospective Study PROTECT protective effect recipient Relapse respiratory response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose secondary Secondary endpoints Seroconversion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein subsequent T cell T cell response T cell responses T cells T-cell the patient the vaccine therapy treated vaccination Vaccine [DOI] 10.1016/j.jtct.2022.04.017 PMC 바로가기 [Article Type] Article
Natural killer cell homing and trafficking in tissues and tumors: from biology to application Reviews Published on 2022-06-292022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] Affect Allogeneic Alter blood circulation Bone marrow Cancer Cancer immunotherapy cancer treatment cancers CAR cells cellular chemokine chemokine receptors chimeric antigen receptor clinical utility cytokine Cytokines Defense develop Evidence Ex vivo expansion Factor Factors homing Immunotherapy IMPROVE infiltration Innate lymphoid cells Integrins limit lymphoid organs lymphoid tissues mechanism microenvironment natural natural killer cell NK cell peripheral tissues profile receptors solid tumors Steady state subset tissue transcriptional transfer transferred Treatment [DOI] 10.1038/s41392-022-01058-z [Article Type] Reviews
Immune response to vaccination against SARS-CoV-2 in hematopoietic stem cell transplantation and CAR T-cell therapy recipients조혈모세포이식 및 CAR T-세포 치료 수혜자의 SARS-CoV-2 예방접종에 대한 면역반응Article Published on 2022-06-162022-09-12 Journal: Journal of Hematology & Oncology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition affected Analysis Antigen booster dose CAR CAR-T cellular response chimeric antigen receptor Chimeric antigen receptor T-cell (CAR-T) therapy conducted COVID-19 vaccine Efficacy evaluate healthy individuals Hematopoietic stem cell Hematopoietic stem cell transplantation (HSCT) HSCT HSCT recipients humoral immune response immunosuppressive increased risk indicated Lymphocyte count outcome Patient receptor recipient recipients required Research response to vaccination SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination Seroconversion significantly significantly higher Stem cell transplantation T-cell therapy Undetermined vaccination Vaccination strategy [DOI] 10.1186/s13045-022-01300-9 PMC 바로가기 [Article Type] Article
Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19 Research Published on 2022-05-112022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제, [키워드] ACE2 Allogeneic CAR Cell chimeric chimeric antigen receptor COVID-19 cytotoxicity Diseases domain experiments Express expressing Extracellular human ACE2 IFN-γ IL-15 immune in vitro in vivo Infection Intervention live SARS-CoV-2 maintain natural killer natural killer cell NK cell NK cells Patient reduce SARS-CoV-2 SARS-CoV-2 spike protein secreting subunit survival the spike protein therapy therapy for COVID-19 TNF-α transgenic mice treating COVID-19 Treatment Viral load viral particle [DOI] 10.1038/s41467-022-30216-8 [Article Type] Research