Screening of Chloroquine, Hydroxychloroquine and its derivatives for their binding affinity to multiple SARS-CoV-2 protein drug targets클로로퀸, 하이드 록시 클로로 퀴인 및 다중 SARS-COV-2 단백질 약물 표적에 대한 결합 친화력에 대한 유도체의 스크리닝Article Published on 2021-09-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] active site binding binding affinity Chloroquine Chloroquine derivatives clinician conducted COVID-19 COVID-19 pandemic derivative derivatives disrupting drug target Efficacy enzyme Enzymes Health authority Hydroxychloroquine implicated in silico approaches Infection inhibit mechanism of action molecular docking multiplication non-structural protein non-structural proteins Pathogenesis pathogenesis of SARS-CoV-2 Potential treatment Protein Proteins remodeling Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 replication SARS-CoV-2 viral Screening selected targets therapeutic potential Viral Viral protein Viral proteins was performed [DOI] 10.1080/07391102.2020.1782265 PMC 바로가기 [Article Type] Article
In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridizationarticle Published on 2021-04-302024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] Chloroquine derivatives Hydrazones Imines malaria [Article Type] article
Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria해양 천연물의 스크리닝을 통한 트리파노소마티드 및 말라리아에 대한 새로운 약물 후보 물질 탐색Review Published on 2020-03-312024-08-11 Journal: Marine Drugs [Category] 말라리아, [키워드] Chloroquine derivatives High-throughput screening malaria marine pharmacology neglected tropical diseases phenotypic screening target-based screening Trypanosomatids [DOI] 10.3390/md18040187 PMC 바로가기 [Article Type] Review
Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria말라리아 치료를 위한 새로운 클로로퀸 유도체의 항말라리아 효과Research Published on 2017-02-172024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Anti-malarial efficacy Chloroquine derivatives SKM13 α,β-unsaturated amides [DOI] 10.1186/s12936-017-1725-z PMC 바로가기 [Article Type] Research