Plasmer: an Accurate and Sensitive Bacterial Plasmid Prediction Tool Based on Machine Learning of Shared k-mers and Genomic Featuresarticle Published on 2023-05-162024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] Bacteria benchmark chromosome genomic features k-mer machine learning Plasmid prediction tool Random forest shared k-mers [DOI] 10.1128/spectrum.04645-22 PMC 바로가기 [Article Type] article
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeArticle Published on 2022-11-032022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] Analysis association chromosome Cohort controls country COVID-19 Deleterious disease expected Genetic genetics Genome-wide association study identify increase in initiative loci outcome outcomes Pathogenesis performed rare variant Result severe disease Support susceptibility the SARS-CoV-2 TLR7 Toll-like receptor variant whole-genome sequencing with COVID-19 [DOI] 10.1371/journal.pgen.1010367 PMC 바로가기
Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2막횡단 세린 프로테아제 TMPRSS2를 중심으로 SARS-CoV-2에 의해 유도된 후각장애와 관련된 분자 기전Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anosmia Apoptosis blockade camostat caused cell entry cellular and molecular chromosome chromosome 21 cleaving Delta dependent on disease disorder dysfunction entry of SARS-CoV-2 event ExoN exons facilitate functional gene encoding Genetic variations help host cell Inflammation involved mechanism nafamostat neuronal number of symptoms olfactory dysfunction olfactory neuroepithelium omicron overcome pandemic virus receptor receptors risk SARS-CoV-2 Serine serine protease serine protease inhibitor serine protease inhibitors shown strain Strains Symptoms therapeutic TMPRSS2 transmembrane serine protease viral S protein virus [DOI] 10.1007/s00705-022-05545-0 PMC 바로가기 [Article Type] Review
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection KineticsArticle Published on 2022-09-122022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addition Analysis B.1 B.1.617.2 BAC BAC mutagenesis backbone Bacterial bronchial epithelial cells Carrying chromosome clinical comparable coronavirus Cytopathic effect disease Efficiency en passant mutagenesis epithelial cell line evaluate generate glycoprotein human lung Infection Infectious virus inhibitors isolate isolates Kinetics less Microscopy monoclonal antibody Mutagenesis Mutation neutralization nonstructural proteins nucleocapsid Numerous Post-vaccine Potential progression raise recombinant RNA role SARS-CoV-2 sera severity spike spike mutation spike mutations Spike protein Substitution suggested susceptible Syncytia Transmissibility Treatment variant viral fitness viral spike virus Virus life cycle VoC [DOI] 10.3390/v14092017 PMC 바로가기
DOCK2 is involved in the host genetics and biology of severe COVID-19 Research Published on 2022-08-082022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, [키워드] age Analysis Biomarker characterized chromosome Cohort collected conducted controls COVID-19 decreased expression DOCK2 downregulation dysregulated East Asian Europeans expression Factor Genetic Genome-wide association study GWAS highlighting Host host genetics Host immune response identifying individual individuals initial involved Japanese less lung Macrophage Non-classical monocytes oedema pandemic Patient Peripheral blood Pneumonia populations prevalent recruitment responses risk allele RNA-sequencing SARS-COV-2 infection Severe case severe COVID-19 Severe COVID-19 pneumonia severity specimen suppressed therapeutic target type I interferon variant viral loads weight loss younger patients [DOI] 10.1038/s41586-022-05163-5 [Article Type] Research
Epigenetic mechanisms regulate sex-specific bias in disease manifestations후성 유전적 메커니즘은 질병 발현에서 성별에 따른 편향을 조절합니다Review Published on 2022-08-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] 유전자 메커니즘, [키워드] affecting Anatomy Autoimmune disorders Cancer change chromosome Clinical outcome clinical study COVID-19 COVID-19 infection differential expression disease disease manifestation disease onset Diseases Effect Epigenetic epigenetic modification epigenetics exhibit explained expression fibrosis Genes Genetic Genetic and epigenetic changes Hormones immune response immune responses immune system implicated inactivation infections input involved Liver fibrosis mechanism Neuropsychiatric Neuropsychiatric diseases progression recent regulate Respiratory disease respiratory diseases response to therapy responsible Sex Sex bias Sex chromosome sex hormone Sex hormones susceptibility therapeutic targets therapy underlying disease X chromosome X-inactivation X-linked X-linked gene X-linked genes. [DOI] 10.1007/s00109-022-02227-x PMC 바로가기 [Article Type] Review
Lp-PLA2 as a biomarker and its possible associations with SARS-CoV-2 infection바이오마커로서의 Lp-PLA2 및 SARS-CoV-2 감염과의 가능한 연관성Review Published on 2022-07-012022-09-11 Journal: Biomarkers in Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] affected association Biomarker Biomarkers cardiovascular condition cardiovascular conditions chromosome chronic obstructive chronic obstructive pulmonary disease COVID-19 Economy enzyme estimation Evidence Exercise Tolerance healthy individuals help hepatic disease hour Inflammation life Lp-PLA2 management marker metabolic condition metabolic conditions obstructive pulmonary disease oxidative stress pathophysiological Pathways PLA2G7 pulmonary disease renal impairment risk SARS-COV-2 infection Serum level serum levels Sickness Signal transduction Tolerance Treatment [DOI] 10.2217/bmm-2021-1129 PMC 바로가기 [Article Type] Review
Chromosome-level and haplotype-resolved genome provides insight into the tetraploid hybrid origin of patchouli Research Published on 2022-06-182022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] Bioactivity biosynthetic gene chromosome components determine duplication Genome genomic identify occurred offer Patchouli Pogostemon provide Research resource reveal whole genome [DOI] 10.1038/s41467-022-31121-w [Article Type] Research
Beyond GWAS-Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?GWAS를 넘어 동종이식 거부 경로 내 유전적 분화가 COVID-19에 대한 자연 면역을 형성할 수 있습니까?Article Published on 2022-06-032022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Allograft allograft rejection Analysis annotation antiviral immunity applied Biomarker Biomarkers chromosome chromosome 6 chromosomes clinical presentation component components COVID-19 COVID-19 infection COVID-19 infections cumulative demonstrated differentiation disease Factor Genetic genetic variants genetics Genome-wide association study genomic GWAS Health help hospitalisation Host identify immune response immune responses immune system immunisation Infection investigated KEGG KEGG pathways Linear model majority mapped metabolic pathway metabolic pathways natural nucleotide outcome pathway Pathways Patient rejection resistance risk Risk assessment self Sequencing severe COVID-19 Severe COVID-19 Infection shape single nucleotide Single nucleotide polymorphism single variant SNP SNPs susceptibility Treatment variant whole genome Whole genome sequencing [DOI] 10.3390/ijms23116272 PMC 바로가기 [Article Type] Article
Of mice and human-specific long noncoding RNAs마우스 및 인간 특이적 긴 비암호화 RNAReview Published on 2022-06-012022-09-11 Journal: Mammalian genome : official journal of the Interna [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach BAC Bacterial bacterial artificial chromosome Cell culture cell culture system cell culture systems chromosome complement conducted coronavirus coronavirus disease Coronavirus disease-19 COVID-19 effort ENCODE etiologic agent example exceeded Genome highlight in vivo integration lncRNA long noncoding RNA mechanism mice MOST mouse offer pandemic protein-coding genes random receptor Regulation SARS-CoV-2 severe acute respiratory syndrome Coronavirus upstream Vascular [DOI] 10.1007/s00335-022-09943-2 PMC 바로가기 [Article Type] Review