Spatio-temporal modelling of referrals to outpatient respiratory clinics in the integrated care system of the Morecambe Bay area, EnglandResearch Published on 2024-02-222024-09-05 Journal: BMC Health Services Research [Category] update2024, [키워드] chronic respiratory disease integrated care Outpatient referrals routinely collected data spatio-temporal [DOI] 10.1186/s12913-024-10716-7 PMC 바로가기 [Article Type] Research
A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study)Article Published on 2022-09-272022-11-15 Journal: BMC Medicine [Category] SARS, 진단, [키워드] 95% confidence interval Administered age airway Analysis asymptomatic patients Bayesian camostat camostat mesilate cardiovascular diseases cells Chronic kidney disease chronic respiratory disease clinical conducted consecutive negative test conversion COVID-19 COVID-19 symptom Diabetes Mellitus dose double-blind Drug screening effective Efficacy and safety eight enrolled evaluate Factor first test hospital human airway epithelial hypertension indicated Japan median time Mild moderate multicenter no significant difference obesity parallel-group Patient patients patients with COVID-19 Placebo placebo-controlled study Positive test Prevent primary efficacy endpoint Randomized Randomized controlled trial receive reduce registry SARS-CoV-2 SARS-COV-2 infection the placebo group the primary endpoint Treatment two groups underlying disease viral clearance viral loads was performed were blinded were excluded without symptoms [DOI] 10.1186/s12916-022-02518-7 PMC 바로가기
COVID-19 in New South Wales children during 2021: severity and clinical spectrumArticle Published on 2022-09-192022-11-16 Journal: The Medical journal of Australia [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute respiratory syndrome adjusted odds ratio Admission Admissions age analyses Analysis Asymptomatic Care Childhood diseases children chronic respiratory disease clinical factor cohort study coronavirus coronavirus disease COVID-19 declined delta variant Epidemics Frequency greater Health home care Home care services, hospital-based hospital Hospital admission hospitalised infancy Infants infections Inflammatory intensive care likelihood Local Medical conditions morbidity MOST network New outbreak outcome positive Prospective random SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid severity South syndrome Virtual care were recorded wheeze with mild disease [DOI] 10.5694/mja2.51661 PMC 바로가기
Multi-disciplinary community respiratory team management of patients with chronic respiratory illness during the COVID-19 pandemicObservational Study Published on 2022-08-132022-10-04 Journal: NPJ Primary Care Respiratory Medicine [Category] 임상, 치료법, [키워드] Admission Admissions analysed benefit carried chronic obstructive chronic respiratory chronic respiratory disease Community correlated COVID-19 pandemic death Electronic health record highest Hospital admission implementation Infection Interaction Linear regression management Mortality NHS nosocomial COVID-19 occurred outcome pathway Pathways Patient Poisson model proportion pulmonary disease Rate reducing reduction in respiratory response secondary care severity significant decrease significantly higher team Triage Trust [DOI] 10.1038/s41533-022-00290-y PMC 바로가기 [Article Type] Observational Study
Immunogenicity and immune-persistence of the CoronaVac or Covilo inactivated COVID-19 Vaccine: a 6-month population-based cohort studyArticle Published on 2022-08-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibody Characteristics chronic respiratory disease CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines delta variant detectable disease Dynamic changes Effectiveness elicited Emergency use IgM response immunogenicity Immunoglobulin inactivated Inactivated vaccine investigated live SARS-CoV-2 neutralizing antibody nucleocapsid Older age pandemic persistence population-based cohort Protective Protein pseudovirus recipient responses SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2-specific antibodies seroconversion rates seroconverted significantly lower the SARS-CoV-2 vaccination Vaccine vaccine dose wildtype [DOI] 10.3389/fimmu.2022.939311 PMC 바로가기
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release인간 폐 섬유아세포는 증가된 IL6 유전자 발현 및 방출을 통해 유도된 염증 기억을 나타냅니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACTA2 affected Analysis ANOVA Cell cell line cell lines chronic respiratory disease chronic respiratory diseases Col1a1 contribute COVID-19 determine determined by downregulated ELISA fibroblast fibroblasts fibrosis followed by Gene Expression Human human lung IL1B IL2 IL6 IL8 Immunity Increased induced Inflammatory inflammatory memory Inflammatory response inhibition inhibitor interleukin-6 investigated involved lung memory Mmp8 mRNA expression multiple groups NF-κB not affect pathway Pathways Poly (I:C) POSTN predict qRT-PCR Release respiratory diseases respond SARS-CoV-2 SARS-CoV-2 spike protein significantly significantly increased Simultaneous Simultaneous treatment Spike protein statistical significance subsequent TGFB1 TLR3 TNFα trained immunity treated Treatment two-way ANOVA viral infection was determined were measured were used Withdrawal [DOI] 10.3389/fimmu.2022.921728 PMC 바로가기 [Article Type] Article
Characteristics and outcomes of ambulatory patients with suspected COVID-19 at a respiratory referral center호흡기추천센터에서 이동하는 코로나19 의심환자의 특징 및 결과Article Published on 2022-06-012022-09-11 Journal: Respiratory medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory symptom acute respiratory symptoms ambulatory ambulatory patient Ambulatory respiratory infections analyzed Asthma baseline Care characteristics of patient chronic respiratory disease clinic clinical Clinical prediction. Comorbidities Composite COPD COVID-19 COVID-19 diagnosis COVID-19 vaccination CRD demographics diagnose Diagnosis elevated Eosinopenia expiratory febrile FEV forced expiratory volume Gender global pandemic help hospital Laboratory tests logit lymphocytosis male management medical record medications neutrophilia outcome oxygen oxygen saturation Patient patient disposition PCR Positive test predicted Pulmonary function tests R package referred to respiratory respiratory infections respiratory rate risk SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 PCR seeking SPO Symptom temperature variants Vital vital signs vitals Volume was used WBC were used with COVID-19 [DOI] 10.1016/j.rmed.2022.106832 PMC 바로가기 [Article Type] Article
Efficacy of high-dose intravenous immunoglobulin in severe and critical COVID-19: A retrospective cohort study중증 및 중증 코로나19에서 고용량 정맥 면역글로불린의 효능: 후향적 코호트 연구Article Published on 2022-05-012022-09-12 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 진단, [키워드] 28-day mortality adjusted administration age analyses Analysis analyzed APACHE II score Care chronic respiratory disease COVID-19 COVID-19 disease COVID-19 severity Critical critical COVID-19 patients dysregulated immune response early administration Efficacy evaluate group High-dose hospital ICU ICU admission immunoglobulins immunomodulatory therapy IMPROVE in-hospital mortality initial intensive care Intravenous immunoglobulin invasive ventilation less Linear regression management mechanical ventilation Mortality negativity obesity outcome outcomes Oxygen requirements Patient patient selection performed reduced retrospective cohort study Retrospective study secondary Severe COVID-19 Infection significantly standard treatment supplemental oxygen Ventilation [DOI] 10.1016/j.intimp.2022.108615 PMC 바로가기 [Article Type] Article
A Battle against COVID-19: Vaccine Hesitancy and Awareness with a Comparative Study between Sinopharm and AstraZenecaArticle Published on 2022-02-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adverse effect AstraZeneca Awareness battle booster chronic respiratory disease Comparative complications conducted Confusion COVID-19 COVID-19 infection COVID-19 vaccination cross-sectional demonstrated Evidence Hesitancy intensity lack participant Participants question receiving reported safety profile Side effect significantly higher Sinopharm Symptom vaccination Vaccine vaccine administration Vaccines [DOI] 10.3390/vaccines10020292 PMC 바로가기 [Article Type] Article
Observed and predicted premature mortality in Australia due to non-communicable diseases: a population-based study examining progress towards the WHO 25X25 goalResearch Article Published on 2022-02-102022-10-28 Journal: BMC Medicine [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] age age and sex average calculated Cancer cardiovascular disease cause-specific mortality chronic respiratory disease chronic respiratory diseases condition conducted COVID-19 pandemic death declined diabete diabetes effort evaluate group highest male men and women Mortality mortality rate Non-communicable disease non-communicable diseases Observed occurred Older Poisson regression predict predicted Premature Premature mortality Probability reduction reduction in Registered Respiratory disease Result Sex sociodemographic factors supplementary material the WHO Variation WHO WHO 25X25 goal World Health Organization’ [DOI] 10.1186/s12916-022-02253-z PMC 바로가기 [Article Type] Research Article